Biological characterization of surface-treated dental implant materials in contact with mammalian host and bacterial cells: titanium <i>versus</i> zirconia

Siddiqui, Danyal A.; Jacob, Joan; Fidai, Alikhan B.; Rodrigues, Danieli C.

doi:10.1039/c9ra06010c

Cited by 9 publications

(8 citation statements)

References 64 publications

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“…Another in vivo study also demonstrated that during experimental plaque accumulation, the total number of bacteria around the Ti implants and the counts of Tannerella forsythia (T. forsythia) and Prevotella intermedia (P. intermedia) were higher than in the zirconia implants and produced a stronger inflammatory response ( Clever et al, 2019 ). However, some studies have come to a different conclusion, for example, when Siddiqui et al evaluated the growth of oral early colonising bacteria and mammalian host cells on commercial pure Ti and zirconium oxide surfaces, in which they found no significant difference in the bacterial counts of Streptococcal strains adhering to commercial pure Ti and zirconium oxide surfaces after 1 or 3 days ( Siddiqui et al, 2019 ). The reasons for this variation may be as diverse as the experimental set-up, the strain, the surface treatment, etc.…”

Section: Intrinsic Antibacterial Materialsmentioning

confidence: 99%

Overview of strategies to improve the antibacterial property of dental implants

Zhai,

Tian,

Shi

et al. 2023

Front. Bioeng. Biotechnol.

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The increasing number of peri-implant diseases and the unsatisfactory results of conventional treatment are causing great concern to patients and medical staff. The effective removal of plaque which is one of the key causes of peri-implant disease from the surface of implants has become one of the main problems to be solved urgently in the field of peri-implant disease prevention and treatment. In recent years, with the advancement of materials science and pharmacology, a lot of research has been conducted to enhance the implant antimicrobial properties, including the addition of antimicrobial coatings on the implant surface, the adjustment of implant surface topography, and the development of new implant materials, and significant progress has been made in various aspects. Antimicrobial materials have shown promising applications in the prevention of peri-implant diseases, but meanwhile, there are some shortcomings, which leads to the lack of clinical widespread use of antimicrobial materials. This paper summarizes the research on antimicrobial materials applied to implants in recent years and presents an outlook on the future development.

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Section: Intrinsic Antibacterial Materialsmentioning

confidence: 99%

Overview of strategies to improve the antibacterial property of dental implants

Zhai,

Tian,

Shi

et al. 2023

Front. Bioeng. Biotechnol.

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“…[27][28][29] Studies emphasized that there was a positive correlation between surface roughness produced in response to aging and bacterial colonization. 23,[30][31][32] To evaluate the adherent microbial count on the material surface, samples were gently rinsed with phosphate-buffered saline (PBS)…”

Section: Introductionmentioning

confidence: 99%

“…37 Cell colony numbers were counted, using digital colony counter by placing each agar plate on the illuminated pad and marking on the plate with a pen provided, the number of colony-forming units per 1 ml of the suspension (CFU/ml) was calculated to quantify the microbial adhesion. 38 For accelerated hydrothermal aging, all disc samples were placed in sterilization pouches, each disc was sealed a sterilization pouch in a steam autoclave (Clear autoclave class B, Clear. China).…”

Section: Introductionmentioning

confidence: 99%

Surface Roughness and Bacterial Colonization Of Two Types Of Zirconia (Cubic And Gradient) After Accelerated Hydrothermal Aging. (Comparative In-Vitro Study)

Mansour,

Kamal,

Sherif

2023

Journal of Fundamental and Clinical Research

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Background:The oral cavity is a challenging environment that promotes the aging of dental restorations, causing surface roughness and bacterial adherence. Therefore, those properties of recently introduced gradient zirconia upon aging are under investigation. Aim: To assess the surface roughness and bacterial colonization of two types of zirconia (cubic and gradient) after accelerated hydrothermal aging. Materials and methods: Twenty-six disc-shaped samples (12mm X 1.2mm) were CAD/CAM fabricated. Samples were divided into two equal groups (n=13) according to the material type: Group B: cubic zirconia (BruxZir)and Group I: gradient zirconia (IPS e.max ZirCAD Prime). Finishing, polishing, and glazing of each sample was done followed by surface roughness measurement using a 3D non-contact profilometer. Samples were incubated in artificial saliva and bacterial suspension then total bacterial count of each disc was calculated using colony-forming units (CFUs/ml). Results: Regardless of aging IPS e.max ZirCAD Prime (0.2535± 0.0043) showed lower surface roughness than BruxZir (0.2552 ± 0.0037). Both types of zirconia showed an increase in surface roughness after aging (0.2581± 0.0017). Both types of zirconia; BruxZir (5.22 ± 0.81) and IPS e.max ZirCAD Prime (5.18 ± 0.57) showed an equal amount of bacterial colonization. Both types of zirconia showed an increase in bacterial colonization after aging (5.73, ± 0.46). Conclusion: Surface roughness of both materials increased due to aging. Both materials showed increase in bacterial counts after aging. There is a positive correlation between surface roughness and bacterial colonization.IPS e.max ZirCAD Prime can be used clinically as it provides a smoother surface than BruxZir.

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“…However, poor osseointegration is one of the most serious drawbacks of zirconia as a biomaterial. Accordingly, many studies to overcome these problems through surface modification have been actively conducted in recent years [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Stable sol–gel hydroxyapatite coating on zirconia dental implant for improved osseointegration

Kim

Kang

Cheon

et al. 2021

J Mater Sci: Mater Med

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Aside from being known for its excellent mechanical properties and aesthetic effect, zirconia has recently attracted attention as a new dental implant material. Many studies have focused on hydroxyapatite (HA) coating for obtaining improved biocompatibility, however the coating stability was reduced by a byproduct produced during the high-temperature sintering process. In this study, to overcome this problem, we simply coated the zirconia surface with a sol–gel-derived hydroxyapatite (HA) layer and then sintered it at a varied temperature (<1000 °C). The surface showed a nanoporous structure, and there was no crystalline phase other than HA and zirconia when the sintering temperature was 800 °C. The adhesion strength of the HA layer (>40 MPa) was also appropriate as a dental implant application. In addition, in vitro cell experiments using a preosteoblast cell line revealed that the HA-coated zirconia surface acts as a preferable surface for cell attachment and proliferation than bare zirconia surface. In vivo animal experiments also demonstrated that the osteoconductivity of zirconia were dramatically enhanced by HA coating, which was comparable to that of Ti implant. These results suggest that the sol–gel-based HA-coated zirconia has a great potential for use as a dental implant material.

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Biological characterization of surface-treated dental implant materials in contact with mammalian host and bacterial cells: titanium versus zirconia

Abstract: Early-colonizing oral bacterial adhesion and mammal cell proliferation were similar on surface-treated titanium and zirconia.

Cited by 9 publications

References 64 publications

Overview of strategies to improve the antibacterial property of dental implants

Overview of strategies to improve the antibacterial property of dental implants

Surface Roughness and Bacterial Colonization Of Two Types Of Zirconia (Cubic And Gradient) After Accelerated Hydrothermal Aging. (Comparative In-Vitro Study)

Stable sol–gel hydroxyapatite coating on zirconia dental implant for improved osseointegration

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