Biological Composites Based on Fluoropolymers with Hydroxyapatite for Intramedullary Implants

Applied Surface Science

Лапин

Svetlichnyi

et al. 2015

This work analyses the properties of calcium phosphate coatings obtained by pulsed laser deposition on the surface of the ferroelectric polymer material. Atomic force and scanning electron microscopy studies demonstrate that, regardless of the type of sputtering target, the calcium phosphate coatings have a multiscale rough surface that is potentially capable of promoting the attachment and proliferation of osteoblasts. This developed surface of the coatings is due to its formation mainly from a liquid phase. The chemical and crystalline 2 composition of the coatings depends on the type of sputtering target used. It was shown that, regardless of the type of sputtering target, the crystalline structure of the ferroelectric polymer material does not change. Cell viability and adhesion studies of mesenchymal stromal cells on the coatings were conducted using flow cytometry and fluorescent microscopy. These studies indicated that the produced coatings are non-toxic.

Section: Introductionmentioning

confidence: 99%

The formation of calcium phosphate coatings by pulse laser deposition on the surface of polymeric ferroelectric

Applied Surface Science

Лапин

Svetlichnyi

et al. 2015

“…Fluorocarbon plastics are widely used in modern medicine. Examples include implantable products that are manufactured using fluorocarbon plastics and used successfully in various areas of medicine: coverage of defects of the cornea [1], prosthetic blood vessels [2][3], plastic walls of abdominal hernia [4], thromboresistive coatings of coronary stents [5][6] and bone regeneration in orthopedic and trauma treatments [7][8][9][10]. Some fluorocarbon plastics, for example, polyvinylidenefluoride, VDF-TeFE and polyvinylidenefluoride-co-trifluoroethylene have ferroelectric properties [11][12].…”

Section: Introductionmentioning

confidence: 99%

Ferroelectric polymer scaffolds based on a copolymer of tetrafluoroethylene with vinylidene fluoride: Fabrication and properties

Materials Science and Engineering: C

Anissimov

Pustovoytov

et al. 2014

A solution blow spinning technique is a method developed recently for making nonwoven webs of micro- and nanofibres. The principal advantage of this method compared to a more traditional electrospinning process is its significantly higher production rate. In this work, the solution blow spinning method was further developed to produce nonwoven polymeric scaffolds based on a copolymer of tetrafluoroethylene with vinylidene fluoride solution in acetone. A crucial feature of the proposed method is that high-voltage equipment is not required, which further improves the method's economics. Scanning electron microscopy analysis of the samples demonstrated that the surface morphology of the nonwoven materials is dependent on the polymer concentration in the spinning solution. It was concluded that an optimum morphology of the nonwoven scaffolds for medical applications is achieved by using a 5% solution of the copolymer. It was established that the scaffolds produced from the 5% solution have a fractal structure and anisotropic mechanical properties. X-ray diffraction, infrared spectroscopy, Raman spectroscopy and differential scanning calorimetry demonstrated that the fabricated nonwoven materials have crystal structures that exhibit ferroelectric properties. Gas chromatography has shown that the amount of acetone in the nonwoven material does not exceed the maximum allowable concentration of 0.5%. In vitro analysis, using the culture of motile cells, confirmed that the nonwoven material is non-toxic and does not alter the morpho-functional status of stem cells for short-term cultivation, and therefore can potentially be used in medical applications.

“…Fluorinated polymer materials are ubiquitous in modern medicine and are used in implants [1], membranes [2], coating of intravascular stents [3], the composite coatings [4], and the scaffolds for regenerative medicine [5,6]. A central role in the interaction of fluorinated polymer material with living tissues is played by its surface properties.…”

Section: Introductionmentioning

confidence: 99%

Research of the surface properties of the thermoplastic copolymer of vinilidene fluoride and tetrafluoroethylene modified with radio-frequency magnetron sputtering for medical application

Tverdokhlebov

Applied Surface Science

Shesterikov

et al. 2012

The properties of thin calcium-phosphate coatings formed by radio-frequency magnetron sputtering of a solid target made from hydroxyapatite on the surface of the thermoplastic copolymer of Vinilidene Fluoride and Tetrafluoroethylene (VDF-TeFE) were investigated. Atomic force microscopy energy dispersive analysis and optical goniometry showed that deposited calcium-phosphate coatings change significantly the morphological, electrical, chemical, and contact properties of the surface of the initial polymeric substrates. These modified surfaces widen the scope of medical application of the thermoplastic copolymer.