Biological Control of Mosquito Vectors: Past, Present, and Future

Benelli, Giovanni; Jeffries, Claire L.; Walker, Thomas

doi:10.3390/insects7040052

Cited by 339 publications

(268 citation statements)

References 161 publications

(202 reference statements)

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“…We then showed that more in-depth study of mosquito ecology and behaviors, which can give us direct information about individual parameters, was more eﬃcient in terms of improving model identifiability. Unfortunately, obtaining accurate measurements for any of these parameters individually can be very diﬃcult in practice, as they often vary depending on environmental and ecological factors such as temperature, weather events such as storms, and predation by other species (Kraemer et al, 2015; Wu et al, 2013; Morrison et al, 2008; Chang et al, 2011; Benelli et al, 2016) We would also need additional information on most of the parameters to make the model fully identifiable, which may not always be feasible. Nevertheless, it is still likely possible to measure the relative magnitude of some parameter subsets (e.g.…”

Section: Discussionmentioning

confidence: 99%

Practical unidentifiability of a simple vector-borne disease model: Implications for parameter estimation and intervention assessment

Kao

Eisenberg

2018

Epidemics

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Mathematical modeling has an extensive history in vector-borne disease epidemiology, and is increasingly used for prediction, intervention design, and understanding mechanisms. Many studies rely on parameter estimation to link models and data, and to tailor predictions and counterfactuals to specific settings. However, few studies have formally evaluated whether vector-borne disease models can properly estimate the parameters of interest given the constraints of a particular dataset. Identifiability analysis allows us to examine whether model parameters can be estimated uniquely—a lack of consideration of such issues can result in misleading or incorrect parameter estimates and model predictions. Here, we evaluate both structural (theoretical) and practical identifiability of a commonly used compartmental model of mosquito-borne disease, using the 2010 dengue epidemic in Taiwan as a case study. We show that while the model is structurally identifiable, it is practically unidentifiable under a range of human and mosquito time series measurement scenarios. In particular, the transmission parameters form a practically identifiable combination and thus cannot be estimated separately, potentially leading to incorrect predictions of the effects of interventions. However, in spite of the unidentifiability of the individual parameters, the basic reproduction number was successfully estimated across the unidentifiable parameter ranges. These identifiability issues can be resolved by directly measuring several additional human and mosquito life-cycle parameters both experimentally and in the field. While we only consider the simplest case for the model, we show that a commonly used model of vector-borne disease is unidentifiable from human and mosquito incidence data, making it diﬃcult or impossible to estimate parameters or assess intervention strategies. This work illustrates the importance of examining identifiability when linking models with data to make predictions and inferences, and particularly highlights the importance of combining laboratory, field, and case data if we are to successfully estimate epidemiological and ecological parameters using models.

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Section: Discussionmentioning

confidence: 99%

Practical unidentifiability of a simple vector-borne disease model: Implications for parameter estimation and intervention assessment

Kao

Eisenberg

2018

Epidemics

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“…[19, 81-85, 126, 127]; see [17] for a review). In this present study, the rice fish, O. melastigma showed high predation rates on the dengue vector A. albopictus 2 nd and 3 rd instar larvae post-treatment with very low doses of AgNP.…”

Section: Impact Of Ag Nanoparticles On Oryzias Melastigma Predationmentioning

confidence: 99%

“…Larvivorous fishes are being successfully exploited for control of mosquito vectors aquatic stages in European, Asian, African and Arabian countries [21,65]. Moreover, the larvivorous fishes provide dual benefits by reducing the mosquito populations and indirectly augmenting the aqua cultural economics [26,73,114,132]; see [17] for a recent review).…”

Section: Introductionmentioning

confidence: 99%

Do Chenopodium ambrosioides-Synthesized Silver Nanoparticles Impact Oryzias melastigma Predation Against Aedes albopictus Larvae?

et al. 2016

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The green synthesis of nanopesticides has been recently proposed to improve the efficacy of mosquito control programs. However, limited efforts shed light on the impact of sub-lethal doses of nanopesticides on behavioral traits of mosquito biocontrol agents. We described the synthesis of silver nanoparticles (AgNP) at room temperature using the aqueous extract of Chenopodium ambrosioides, and their high toxicity against the invasive mosquito Aedes albopictus. LC 50 calculated on young instars ranged from 13 ppm (first instar larvae) to 19 ppm (pupae). LC 50 calculated on adults was 14 ppm. The chemical composition of the C. ambrosioides extract was characterized by GC-MS analysis.

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“…Successful transinfections of Wolbachia strains from Drosophila flies to Aedes mosquitoes have resulted in the generation of mosquito lines refractory to arboviruses including ZIKV [43][44][45]. Different mechanisms have been suggested to explain the molecular basis of the pathogen-blocking phenotype: upregulation of immune genes, or production of reactive oxygen species, or competition for limited resources such as cholesterol [46].…”

mentioning

confidence: 99%

Culex quinquefasciatus mosquitoes do not support replication of Zika virus

Lourenço‐de‐Oliveira

Marques

Sreenu

et al. 2018

Journal of General Virology

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The rapid spread of Zika virus (ZIKV) in the Americas raised many questions about the role of Culex quinquefasciatus mosquitoes in transmission, in addition to the key role played by the vector Aedes aegypti. Here we analysed the competence of Cx. quinquefasciatus (with or without Wolbachia endosymbionts) for a ZIKV isolate. We also examined the induction of RNA interference pathways after viral challenge and the production of small virus-derived RNAs. We did not observe any infection nor such small virus-derived RNAs, regardless of the presence or absence of Wolbachia. Thus, Cx. quinquefasciatus does not support ZIKV replication and Wolbachia is not involved in producing this phenotype. In short, these mosquitoes are very unlikely to play a role in transmission of ZIKV. Micronesia and then in French Polynesia in 2013-2014, and after affecting most of the South Pacific islands, the virus was eventually detected in the Americas in 2015 [1][2][3][4]. The increased number of infections in humans included cases with unusually severe symptoms such as Guillain-Barr e syndrome and developmental abnormalities in newborns that are now described as congenital Zika syndrome [5][6][7][8]. As there are currently no licensed vaccines or specific therapies, the only way to interrupt ZIKV transmission is by controlling mosquito populations [9]. An enzootic cycle limited to Africa and Asia with occasional spillover events has been described [10,11]. In the current outbreak in the Americas, ZIKV is believed to be mainly transmitted by the human-biting mosquito Aedes aegypti [12,13]. Whether a similar enzootic cycle in the Americas can be established is not known and it has been suggested that such a process would make eradication efforts 'practically impossible' [14]. Experimental infections with the epidemic ZIKV genotypes demonstrated that populations of Ae. aegypti and Ae. albopictus mosquitoes, which are associated with a risk of local transmission [15] as well other aedine species were heterogeneously and weakly competent for transmission [16][17][18][19][20][21][22][23][24][25]. Therefore, the potential role of other anthropophilic mosquitoes in the ZIKV outbreak raised a question which took time to be addressed [26]. Culex quinquefasciatus Say is an opportunistic blood feeder predominant in urban settings throughout the tropics where it is frequently the most annoying biting pest to humans [27]. This night-active mosquito is also the vector of many pathogens including arboviruses such as West Nile and St. Louis encephalitis viruses [28], which belong to the genus Flavivirus of the family Flaviviridae and are related to ZIKV. Both Cx. quinquefasciatus and Culex pipiens (from temperate regions) mosquitoes of the Cx. pipiens complex were not able to experimentally transmit ZIKV and no viral particles were detected in mosquito saliva up to 21 days after exposure to an infectious blood meal [17-20, 25, 29-36], though different results were recorded with other Cx. quinquefasciatus strains [37,38]. Even after injection o...

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Biological Control of Mosquito Vectors: Past, Present, and Future

Cited by 339 publications

References 161 publications

Practical unidentifiability of a simple vector-borne disease model: Implications for parameter estimation and intervention assessment

Practical unidentifiability of a simple vector-borne disease model: Implications for parameter estimation and intervention assessment

Do Chenopodium ambrosioides-Synthesized Silver Nanoparticles Impact Oryzias melastigma Predation Against Aedes albopictus Larvae?

Culex quinquefasciatus mosquitoes do not support replication of Zika virus

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