Biological correlates of FDG uptake in non-small cell lung cancer

Geus‐Oei, Lioe‐Fee de; Krieken, J. Han J.M. van; Aliredjo, R.P.; Krabbe, Paul F M; Frielink, Cathelijne; Verhagen, Ad F. T. M.; Boerman, Otto C.; Oyen, Wim J.G.

doi:10.1016/j.lungcan.2006.08.018

Cited by 180 publications

(162 citation statements)

References 41 publications

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“…The lower SUVmax of adenocarcinomas is consistent with the results of other studies [1,2]. Tumour subtype is known to reflect the differential avidity of 18FDG uptake by cancer cells [21].…”

Section: Discussionsupporting

confidence: 89%

“…We evaluated tumour mass dimension, CT pre-average , CT post-average , CT post-max , net enhancement, SUVmax, age, and cytological data of 38 patients. Recent studies have focused on the relationship between the SUV and biological and molecular factors that influence cancer progression or glucose metabolism [11,12]. Malignant cells exhibit increased glucose metabolism and uncontrolled growth: elevated glucose metabolism and high levels of angiogenesis are both associated with increased metastatic potential and poor patient survival [13].…”

Section: Discussionmentioning

confidence: 99%

“…FDG uptake is known to be related to hexokinase and glucose-6-phosphatase activities in cancer [24,25]. Moreover, at the whole tumour level, FDG depends on such factors as tumour blood flow, intratumoral microvessel density and viable tumour cell number [2]. Uptake of FDG in the primary site of NSCLC has been correlated with tumour doubling time and proliferation rates [2,18].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, at the whole tumour level, FDG depends on such factors as tumour blood flow, intratumoral microvessel density and viable tumour cell number [2]. Uptake of FDG in the primary site of NSCLC has been correlated with tumour doubling time and proliferation rates [2,18]. In fact, the doubling time of squamous cell carcinoma is 92 days versus 168 in the case of adenocarcinoma [18].…”

Section: Discussionmentioning

confidence: 99%

“…Lung cancer is the most frequent cause of cancer mortality [1] in both men and women [2,3]. There are 2 main types of primary lung cancer, which are classified according to cellular population involved: non-small cell lung cancer (NSCLC) and small cell lung cancer.…”

Section: Introductionmentioning

confidence: 99%

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Studio comparativo con esame TC contrastografico e con PET-TC del tumore polmonare non a piccole cellule

et al. 2013

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BackgroundPersonalized cancer therapy remains a challenge. In this context, we attempted to identify correlations between tumour angiogenesis, tumour metabolism and tumour cell type. To this aim, we used single=phase multidetector computed tomography (MDCT) and hybrid positron emission tomography-computed tomography (PET/CT) to determine whether net enhancement and standardized uptake value (SUVmax) were correlated with tumour size and cytology in patients affected by non-small cell lung cancer (NSCLC).Material/MethodsOur study included 38 patients (30 men, 8 women, mean age 70) with a NSCLC measuring between 3 cm and 7 cm, using a 16-slice multidetector CT (Brilliance Philips) and with PET-CT (Biograph 16 Siemens Medical Solutions). The following lesion parameters were evaluated: maximum diameter, medium density before contrast injection (CTpre), medium density after contrast injection (CTpost average), density in the most enhanced part of the lesion after contrast (CTpost max), net enhancement, SUVmax, age, and cytology. Correlation coefficient and p-value were computed for each pair of variables. In addition, correlations were computed for each pair of variables, and for all combinations of tumour types. We focused on subsets of data with more than 10 observations, and with correlation r>0.500 and p<0.05.ResultsA weak correlation (r=0.32; p=0.048) was found between SUVmax and tumour size; the correlation was stronger for masses larger than 31 mm (r=0.4515; p=0.0268). No other correlations were found among the variables examined.ConclusionsOur data may have prognostic significance, and could lead to more appropriate surgical treatment and better treatment outcome.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Studio comparativo con esame TC contrastografico e con PET-TC del tumore polmonare non a piccole cellule

et al. 2013

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Distribution and prognostic significance of gluconeogenesis and glycolysis in lung cancer

et al. 2020

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Do fine needle aspirate cytomorphological features correlate with positron emission tomography findings of metastatic non‐small cell lung carcinoma in lymph nodes?

Keyhanian

Sekhon

2023

Cancer Medicine

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Background: Our objective was to correlate cytomorphological features of metastatic non-small cell lung carcinoma (mNSCLC) with maximal standardized uptake value (mSUV) of positron emission tomography (PET) in Lymph nodes (LNs). Methods:Positive cytology slides of 114 LNs were reviewed from 100 patients with mNSCLC who had undergone PET study. Student's t-test was used for statistical comparisons.

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Biological correlates of FDG uptake in non-small cell lung cancer

Cited by 180 publications

References 41 publications

Studio comparativo con esame TC contrastografico e con PET-TC del tumore polmonare non a piccole cellule

Studio comparativo con esame TC contrastografico e con PET-TC del tumore polmonare non a piccole cellule

Distribution and prognostic significance of gluconeogenesis and glycolysis in lung cancer

Do fine needle aspirate cytomorphological features correlate with positron emission tomography findings of metastatic non‐small cell lung carcinoma in lymph nodes?

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