Biological definition of multiple chemical sensitivity from redox state and cytokine profiling and not from polymorphisms of xenobiotic-metabolizing enzymes

Luca, Chiara De; Scordo, Maria Gabriella; Cesareo, Eleonora; Pastore, Saveria; Mariani, Silvia; Maiani, G.; Stancato, Andrea; Loreti, Beatrice; Valacchi, Giuseppe; Lubrano, Carla; Raskovic, Desanka; Padova, Luigia De; Genovesi, Giuseppe; Korkina, Liudmila

doi:10.1016/j.taap.2010.04.017

Cited by 75 publications

(93 citation statements)

References 52 publications

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“…On the other hand, the allele and genotype frequencies of GSTM1 and GSTT1 were similar in Italian MCS patients and control populations [22]. In our study, no significant differences between the genotype frequency of GSTT1 and GSTM1 were found for any severity of three QEESI subscales or in the case-control study.…”

Section: Discussioncontrasting

confidence: 50%

Factors in genetic susceptibility in a chemical sensitive population using QEESI

Fujimori

Hiura

et al. 2011

Environ Health Prev Med

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Section: Discussioncontrasting

confidence: 50%

Factors in genetic susceptibility in a chemical sensitive population using QEESI

Fujimori

Hiura

et al. 2011

Environ Health Prev Med

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“…These data replicate previous fi ndings on the familial nature of MCS and chemical intolerance. 21,68 Although a detailed discussion of possible biologic mechanisms is beyond the scope of this article, laboratory studies of persons with MCS or chemical intolerance indicate that both central nervous system sensitization 69,70 and infl ammatory processes 9 contribute to the multisystem clinical picture. Both sensitization and chronic infl ammation also play a role in the medical, psychiatric, and substance abuse conditions found at elevated rates in the personal histories, family histories, or both of patients with MCS described in the Introduction and identifi ed in Table 2.…”

Section: Key Findingsmentioning

confidence: 99%

“…1,2 Symptoms are typically multisystem, that is, affecting cognitive, affective, musculoskeletal, gastrointestinal, genitourinary, and cardiovascular systems. 8,9 Despite its relatively high prevalence in nonclinical samples, the diagnosis and etiology of chemical intolerance remain controversial and understudied. Skeptics and proponents often frame the debate in a dualistic manner, claiming that chemical intolerance is either completely psychogenic or completely toxicogenic; however, accumulating data suggest that a more nuanced, multifactorial psychobiological process underlies the condition.…”

mentioning

confidence: 99%

Chemical Intolerance in Primary Care Settings: Prevalence, Comorbidity, and Outcomes

Katerndahl¹,

Bell²,

Palmer³

et al. 2012

The Annals of Family Medicine

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“…Recently, decreased levels of reduced and oxidized glutathione, as well as of glutathione-metabolizing enzyme activities, were reported in erythrocytes of individuals with MCS. 15 At least one published report exists of an individual being prescribed glutathione as a therapy for MCS, 16 numerous websites encourage the therapy, and this survey suggests improvement in patient-reported outcomes with (in)GSH therapy in people with self-reported MCS.…”

Section: Multiple Chemical Sensitivitymentioning

confidence: 87%

Safety Survey of Intranasal Glutathione

Mischley

Vespignani²,

Finnell³

2013

The Journal of Alternative and Complementary Medicine

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Purpose: Glutathione depletion has been documented in several disease states, and exogenous administration has been hypothesized to have therapeutic potential for some conditions. In an effort to reach target tissues of the sinuses and central nervous system (CNS), glutathione is being prescribed as an intranasal spray, although no literature exists to support this mode of administration. The objective of this study was to describe patientreported outcomes in a population of individuals who have been prescribed intranasal reduced glutathione, (in)GSH. Methods: A survey was designed to assess individuals' perception of tolerability, adverse events, and health benefits associated with (in)GSH use. Using a pharmacy database, 300 individuals were randomly selected to receive a survey; any individual who had received one or more prescriptions for (in)GSH between March 2009 and March 2011 was eligible for participation. Results: Seventy (70) individuals returned the survey (23.3% response rate) from 20 different states. Reported indications for (in)GSH prescriptions were multiple chemical sensitivity (MCS) (n = 29), allergies/sinusitis (n = 25), Parkinson disease (PD) (n = 7), Lyme disease (n = 3), fatigue (n = 2), and other (n = 10). Of the respondents, 78.8% (n = 52) reported an overall positive experience with (in)GSH, 12.1% (n = 8) reported having experienced adverse effects, and 62.1% (n = 41) reported having experienced health benefits attributable to (in)GSH use. Over 86% of respondents considered the nasal spray to be comfortable and easy to administer. Conclusions: This is the first study to evaluate patient-reported outcomes among individuals across the country who have been prescribed (in)GSH. The majority of survey respondents considered (in)GSH to be effective and without significant adverse effects. (in)GSH should be further evaluated as a method of treating respiratory and CNS diseases where free-radical burden is a suspected contributor to disease progression.

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Biological definition of multiple chemical sensitivity from redox state and cytokine profiling and not from polymorphisms of xenobiotic-metabolizing enzymes

Cited by 75 publications

References 52 publications

Factors in genetic susceptibility in a chemical sensitive population using QEESI

Factors in genetic susceptibility in a chemical sensitive population using QEESI

Chemical Intolerance in Primary Care Settings: Prevalence, Comorbidity, and Outcomes

Safety Survey of Intranasal Glutathione

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