Biological detoxification of mycotoxins: a review

Hathout, Amal S.; Aly, Soher E.

doi:10.1007/s13213-014-0899-7

Cited by 169 publications

(112 citation statements)

References 158 publications

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“…Our results support the notion that microbiological detoxification is suitable for the decontamination of mycotoxins in feed with high efficiency, strong specificity, and no environmental pollution [41]. …”

Section: Discussionsupporting

confidence: 87%

Effect of Degradation of Zearalenone-Contaminated Feed by Bacillus licheniformis CK1 on Postweaning Female Piglets

Wang

et al. 2016

Toxins

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Zearalenone (ZEA), an estrogenic mycotoxin, is mainly produced by Fusarium fungi. In this study, Bacillus licheniformis CK1 isolated from soil with the capability of degrading ZEA was evaluated for its efficacy in reducing the adverse effects of ZEA in piglets. The gilts were fed one of the following three diets for 14 days: a basic diet for the control group; the basic diet supplemented with ZEA-contaminated basic diet for the treatment 1 (T1) group; and the basic diet supplemented with fermented ZEA-contaminated basic diet by CK1 for the treatment 2 (T2) group. The actual ZEA contents (analyzed) were 0, 1.20 ± 0.11, 0.47 ± 0.22 mg/kg for the control, T1, and T2 diets, respectively. The results showed that the T1 group had significantly increased the size of vulva and the relative weight of reproductive organs compared to the control group at the end of the trial. The T1 group significantly decreased the concentration of the luteinizing hormone (LH) compared with the control and T2 groups. Expression of ERβ was significantly up-regulated in the T2 group compared with the control. In addition, expression of ERβ was not different between the control and the T1 group. In summary, our results suggest that Bacillus licheniformis CK1 could detoxify ZEA in feed and reduce the adverse effects of ZEA in the gilts.

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Section: Discussionsupporting

confidence: 87%

Effect of Degradation of Zearalenone-Contaminated Feed by Bacillus licheniformis CK1 on Postweaning Female Piglets

Wang

et al. 2016

Toxins

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“…It is bile‐resistant microorganism (Yilmaz‐Ersan & Kurdal, ) which can eliminate the detrimental effects of fecal Escherichia coli species and other intestinal pathogenic microorganisms (Yerlikaya, ). According to Hathout and Aly (), L. acidophilus strains can eliminate AFB 1 at high concentration (>50%). Considering to findings of Elsanhoty et al (), L. acidophilus strains lead to the most considerable reduction in AFM 1 quantities.…”

Section: Lactic Acid Bacteriamentioning

confidence: 99%

“…Moreover, based on the report of Corassin et al (), elimination of aflatoxin M 1 is related to bacterial cell wall binding of the LAB without needing any bacterial activity. However, the accurate detoxification mechanism of LABs on aflatoxin has not been explained completely yet, but the assumption is that it would be a physical binding (Dalié, Deschamps, & Richard‐Forget, ; El Khoury, Atoui, & Yaghi, ), and is an adhesiveness to the cell wall elements of bacteria including polysaccharides and peptidoglycans (Hathout & Aly, ; Shetty & Jespersen, ). Also, results of Haskard, Binnion, and Ahokas () and Haskard, ElNezami, Kankaanpää, Salminen, and Ahokas (), showed that polysaccharides and peptidoglycans are mainly responsible for the binding procedure of AFB 1 by Lactobacillus rhamnosus.…”

Section: Detoxification Mechanisms Of Afm1mentioning

confidence: 99%

The detoxification of aflatoxin M₁ by Lactobacillus acidophilus and Bifidobacterium spp.: A review

Fashandi

Abbasi

Khaneghah

2018

J Food Process Preserv

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One of the most studied mycotoxins is Aflatoxin M1 (AFM1), which as a carcinogen should be eliminated or limited from food products especially dairy products. Among different detoxification methods of AFM1, several strains of lactic acid bacteria (LABs) (particularly Lactobacillus acidophilus and Bifidobacterium spp.) can bind Aflatoxin M1 and furthermore, eliminate them. The principal mechanism of detoxification by LABs is the physical binding to peptidoglycan and polysaccharides present in the bacterial cell wall. This paper reviews the detoxification capability of some LABs strains and the critical roles of factors affecting the binding procedures including LAB strains, optimum incubation time, and the cell concentration of LABs. Practical application This study reviewed the impact of lactic acid bacteria on detoxification of aflatoxin M1. As the high toxicity effect of aflatoxin M1 in food is proved, finding a safe method in order to remove them is crucial. Lactic acid bacterias (LABs) are vastly applied in food science and technology due to their various beneficial effects, being easy manageable and safe technique. LABs were completely efficient in the elimination of aflatoxins in food besides having no potential adverse health/toxic effects.

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“…Microbial detoxification is an efficient, specific and environmentally friendly method that does not decrease the nutritional value and palatability of the decontaminated feed commodities . The biological decontamination strategy has been widely studied . It should be emphasized that actual detoxification only occurs when non‐toxic degradation products are formed.…”

Section: Remediation Of Mycotoxins In Silagesmentioning

confidence: 99%

“…On the one hand, a wide variety of microorganisms occurs in silages; on the other hand, multiple microorganisms are known for their mycotoxin degradation capability . In Table , several microorganisms epiphytic to silages are summarized with their mycotoxin degradation capability as found in the literature.…”

Section: Remediation Of Mycotoxins In Silagesmentioning

confidence: 99%

Occurrence, prevention and remediation of toxigenic fungi and mycotoxins in silage: a review

et al. 2016

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Ruminants are considered to be less sensitive towards mycotoxins than monogastric animals because rumen microbiota have mycotoxin-detoxifying capacities. Therefore the effect of mycotoxins towards ruminants has been studied to a lesser extent compared with monogastric animals. Worldwide, a high proportion of the ruminant diet consists of silages made of forage crops (i.e. all parts of the crop above the stubble are harvested). In practice, silages are often contaminated with multiple mycotoxins. Exposure to a cocktail of mycotoxins can hamper animal production and have severe health consequences. In this article the different aspects associated with mycotoxin contamination of silage are reviewed 'from seed to feed'. An overview is given on the occurrence of toxigenic fungal species and their concomitant mycotoxins in forage crops before and after ensiling. The mycotoxin load of visually non-mouldy samples and mouldy hot spots within the same silo is also compared. Subsequently, this review delves into different problem-solving strategies. A logical first step is prevention of mould growth and mycotoxin production in the field, during harvest and during ensiling. If prevention should fail, several remediation strategies are available. These are listed, mainly focusing on the possibilities of microbial degradation of mycotoxins in vivo in silage. © 2015 Society of Chemical Industry.

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Biological detoxification of mycotoxins: a review

Cited by 169 publications

References 158 publications

Effect of Degradation of Zearalenone-Contaminated Feed by Bacillus licheniformis CK1 on Postweaning Female Piglets

Effect of Degradation of Zearalenone-Contaminated Feed by Bacillus licheniformis CK1 on Postweaning Female Piglets

The detoxification of aflatoxin M₁ by Lactobacillus acidophilus and Bifidobacterium spp.: A review

Occurrence, prevention and remediation of toxigenic fungi and mycotoxins in silage: a review

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Biological detoxification of mycotoxins: a review

Cited by 169 publications

References 158 publications

Effect of Degradation of Zearalenone-Contaminated Feed by Bacillus licheniformis CK1 on Postweaning Female Piglets

Effect of Degradation of Zearalenone-Contaminated Feed by Bacillus licheniformis CK1 on Postweaning Female Piglets

The detoxification of aflatoxin M1 by Lactobacillus acidophilus and Bifidobacterium spp.: A review

Occurrence, prevention and remediation of toxigenic fungi and mycotoxins in silage: a review

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The detoxification of aflatoxin M₁ by Lactobacillus acidophilus and Bifidobacterium spp.: A review