Biological Effect of Leaf Aqueous Extract of<i>Caesalpinia pyramidalis</i>in Goats Naturally Infected with Gastrointestinal Nematodes

Santos, Roberto Robson Borges dos; López, Jorge A.; Santos, L.C.S.; Zacharias, Farouk; David, Jorge; David, Juceni P.; Lima, Fernanda Washington de Mendonça

doi:10.1155/2012/510391

Cited by 9 publications

(5 citation statements)

References 25 publications

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“…1,4 Additionally, the aqueous leaf extract of P. pyramidalis has been used to treat gastrointestinal nematodes in goats, with promising results. 3 Pharmacologic studies have shown that aerial parts of the plant have anti-inflammatory, 18 antifungal, 7 and antimicrobial properties. 19 Its pollen has been proven to be toxic to honeybees ( Apis melifera ).…”

Section: Introductionmentioning

confidence: 99%

Embryotoxic effects of Poincianella (Caesalpinia) pyramidalis leaves on pregnant rats

et al. 2017

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We investigated the embryotoxic and fetotoxic effects of Poincianella pyramidalis (Tul.) L.P. Queiroz (syn. Caesalpinia pyramidalis Tul.) leaves on pregnant rats (Rattus norvegicus). Pregnant rats were divided into 4 groups: G1-fed a ration containing 5% P. pyramidalis leaves beginning on day 1 of pregnancy; G2-fed a ration containing 5% P. pyramidalis leaves commencing on day 6 of pregnancy; G3-fed a ration containing 10% P. pyramidalis leaves starting on day 6 of pregnancy; G4-control group. On day 21 of pregnancy, parameters of reproductive performance were recorded. Fetal growth was measured, and fetuses were subjected to external examination and identification of skeletal anomalies. Rations containing P. pyramidalis resulted in dead or undeveloped fetuses and reduced the number, length, and weight of the fetuses. Rations also increased postimplantation losses and the frequency of skeletal anomalies. Furthermore, P. pyramidalis was also responsible for dose-dependent lesions in the placentas. In conclusion, the ingestion of P. pyramidalis promotes fetal and placental damage.

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Section: Introductionmentioning

confidence: 99%

Embryotoxic effects of Poincianella (Caesalpinia) pyramidalis leaves on pregnant rats

et al. 2017

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“…The LBWs of the animals treated with the extract did not change significantly except those treated at the highest dose of 5mg/kg b.w. (Robson et al, 2012). In evaluation of in vivo anthelmintic activity using Boer goats, Worku et al (2009) observed that groups treated with wormwood and tobacco with added copper sulphate resulted in dramatic decreases in PCV values and related this to toxic effects of these plant extracts.…”

Section: 3mentioning

confidence: 99%

In-vivo activity of two herbal plant mixtures against gastrointestinal nematodes in ruminants

Kimani¹,

Kareru²,

Karanja³

et al. 2014

IOSRJAC

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Helminthes infestation is a major constraint to livestock production. Increasing anthelmintic resistance and the impact of conventional anthelmintics on the environment has led to increased interest on new novel plant-based compounds. In this study, the in vivo activity of a herbal extract mixture containing Entada leptostachya and Prosopis juliflora was determined using faecal egg count (FEC) reduction tests on sheep. There were no signs of toxicity in all the groups throughout the study period apart from reduced feed intake in the initiation stage of the experiment. The herbal formula exhibited a time-dependent but not dose-dependent invivo anthelmintic activity. The 500mg/kg b.w.dose produced the maximum faecal egg reduction of 84% while 4500mg/kg b.w.dose gave the least reduction of-59% on day 19 post-treatment (PT). The results of the FEC reduction tests indicated that the herbal formulation tested passed the threshold FEC reduction of 80%. All the groups had an increase in their mean live body weights (LBWs) by day 19 PT except the untreated group. However, none of the increase was significant (P>0.05). All the animals recorded pre-and post-treatment packed cell volume (PCV) values that were within the permissible range of between 24-45% for experimental sheep. All the groups recorded improved PCV values except the doses at 1500mg/kg b.w. and 4500mg/kg b.w. In conclusion, the herbal mixture was, therefore, safe and sufficiently active and has potential as a novel anthelmintic drug for the treatment of gastro-intestinal nematodes in ruminants.

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“…Among the biological activities of P . pyramidalis described in the literature, we can highlight the antibacterial [ 28 , 29 ], antifungal [ 30 ], antioxidant [ 31 ], gastroprotective [ 32 ], anti-inflammatory, antinociceptive [ 33 ] and antihelminthic [ 34 ] activities.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Interaction between the Poincianella pyramidalis (Tul.) LP Queiroz Extract and Antimicrobials Using Biological and Analytical Models

et al. 2016

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Poincianella pyramidalis (Tul.) LP Queiroz (Fabaceae) is an endemic tree of northeastern Brazil, occurring mainly in the Caatinga. Its medicinal use is widespread and is an important therapeutic option against diarrhea, dysentery, and respiratory and urinary infections, among other diseases. In this study we determined the chemical marker and evaluated the interaction between P. pyramidalis extract and a commercial antimicrobial through the use of biological and analytical models. To obtain the extract, an ethanol-water mixture (50:50 v/v) was used as solvent. It was nebulized in a spray dryer using colloidal silicon dioxide as a drying adjuvant. The extract (ENPp) was subjected to HPLC analysis to verify the presence of certain secondary metabolites. The Minimum Inhibitory Concentration (MIC) of the extract against Gram-negative bacteria was determined by broth microdilution and the MIC of synthetic antimicrobial drugs in the presence and absence of the extract. The antioxidant activity of ENPp was evaluated by the DPPH method. The compatibility between the antimicrobial and the extract was evaluated by thermal analysis (TG/DTA). The acute toxicity of the extract was evaluated in vivo in rodents. The results indicate significant additive action of the extract on synthetic antibiotics, considerable antioxidant activity and absence of toxicity. This extract shows high potential for the development of formulations for antimicrobial therapy when used with a vegetable-active ingredient.

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Biological Effect of Leaf Aqueous Extract ofCaesalpinia pyramidalisin Goats Naturally Infected with Gastrointestinal Nematodes

Cited by 9 publications

References 25 publications

Embryotoxic effects of Poincianella (Caesalpinia) pyramidalis leaves on pregnant rats

Embryotoxic effects of Poincianella (Caesalpinia) pyramidalis leaves on pregnant rats

In-vivo activity of two herbal plant mixtures against gastrointestinal nematodes in ruminants

Evaluation of the Interaction between the Poincianella pyramidalis (Tul.) LP Queiroz Extract and Antimicrobials Using Biological and Analytical Models

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