Biological Effects and Antitumor Activity Induced by Benzocaine Conjugated Anionic Polymers

Abstract

Three maleic anhydride copolymers [poly(maleic anhydride-vinyl acetate), poly(maleic anhydride-styrene) and poly(maleic anhydride-methyl methacrylate)] were prepared as well as the corresponding benzocaine conjugates. The maleic anhydride moiety was hydrolyzed to the corresponding polycarboxylate anions and then biologically evaluated using pyran copolymer as the standard. All of the polymers showed internal organ toxicity of the liver, kidneys and spleen which increased with increasing molecular weight, however, the benzocaine derivatives decreased this effect in most cases. The biological evaluations included hemoglobin levels, hematocrit levels, red blood indices and mean cell volumes which were increased on an average of 50%. The blood protein profiles were not changes significantly; on average they were changed about AE50%. The unmodified copolymers decreased the major serum and cholesterol levels by $75%. The copolymers (with or without) benzocaine decreased both the blood sugar and enzyme profiles. The antitumour activity was evaluated against Walker carcinosarconoma; although the benzocaine enhanced these effects, only pyran and the 18,000 Mw benzocaine-modified poly(maleic anhydride-vinyl acetate) produced significant effects.

Monovalent and Divalent Cation Effects on Phase Transitions of ι-carrageenan

“…It is known that phase transition rates and temperatures for the biogels are important in many applications, especially for drug-release processes in the stomach and gastrointestinal tract [19][20][21][22]. This work has produced a considerable amount of data for the cation--carrageenan interactions in water for this purpose.…”

Antitumoral Activity Induced by Alkylating Agents Conjugated to Poly(maleic anhydride-alt-vinyl acetate)

“…Administration of MA copolymers caused significant variation in certain organ weights without significant modification of the body weight [24,25]. The data given in Table 1 indicate that these compounds induced significant weight increases in the liver, spleen, and particularly the kidney (490%).…”

“…It appears that the phenyl structure in Conjugate III ( Figure 5) enhanced its tumor tissue accessibility and thus a better ATR value. However, due to secondary effects during treatment, macromolecule-neoplasmic cell interactions also generate toxic metabolites responsible for the organotropic, hematologic, and physiologic effects [25]. SO …”

Self‐assembly of bovine serum albumin and poly(acrylic acid) induced by noncovalent bonds

“…Using polyanions as protein carriers to resist viruses exhibit great immunoadjuvant activity, which was superior to inoculation method. For example, the primary antibody response to sheep erythrocytes has been enhanced using polyanions 19–21. Among various polyanions, PAA appears much higher antiviral activity and less cytotoxic than others (e.g.…”