Biological effects of alpha particle radiation exposure on human monocytic cells

Chauhan, Vinita; Howland, Matthew; Kutzner, B. C.; McNamee, James P.; Bellier, Pascale V.; Wilkins, Ruth

doi:10.1016/j.ijheh.2011.11.002

Cited by 26 publications

(8 citation statements)

References 56 publications

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“…Such effects can include genetic mutations, generation of reactive oxygen species, modification of cell cycle regulation (e.g., mitotic delay and inhibition of apoptosis), cytokine up and/or down regulation, CAs and MN formation and generation of γ-H2AX species (indicative of double-strand DNA breaks) [244,245]. These effects can vary depending upon a number of different factors including but not limited to dose, frequency of dose, cell type, cellular conditions (such as cell-cycle stage during exposure) and intra and inter signaling between neighbouring cells [10,246–248].…”

Section: Discussionmentioning

confidence: 99%

The Cellular and Molecular Carcinogenic Effects of Radon Exposure: A Review

Robertson

Allen

Laney

et al. 2013

IJMS

124

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Radon-222 is a naturally occurring radioactive gas that is responsible for approximately half of the human annual background radiation exposure globally. Chronic exposure to radon and its decay products is estimated to be the second leading cause of lung cancer behind smoking, and links to other forms of neoplasms have been postulated. Ionizing radiation emitted during the radioactive decay of radon and its progeny can induce a variety of cytogenetic effects that can be biologically damaging and result in an increased risk of carcinogenesis. Suggested effects produced as a result of alpha particle exposure from radon include mutations, chromosome aberrations, generation of reactive oxygen species, modification of the cell cycle, up or down regulation of cytokines and the increased production of proteins associated with cell-cycle regulation and carcinogenesis. A number of potential biomarkers of exposure, including translocations at codon 249 of TP53 in addition to HPRT mutations, have been suggested although, in conclusion, the evidence for such hotspots is insufficient. There is also substantial evidence of bystander effects, which may provide complications when calculating risk estimates as a result of exposure, particularly at low doses where cellular responses often appear to deviate from the linear, no-threshold hypothesis. At low doses, effects may also be dependent on cellular conditions as opposed to dose. The cellular and molecular carcinogenic effects of radon exposure have been observed to be both numerous and complex and the elevated chronic exposure of man may therefore pose a significant public health risk that may extend beyond the association with lung carcinogenesis.

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Section: Discussionmentioning

confidence: 99%

The Cellular and Molecular Carcinogenic Effects of Radon Exposure: A Review

Robertson

Allen

Laney

et al. 2013

IJMS

124

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“…Detectable levels of BPA have been reported in body fluids of humans and animals (Biedermann et al, 2010; Geens et al, 2011; Rubin, 2011) and, thus, BPA exposure has potential health hazards (Rubin, 2011; Rubin and Soto, 2009; Talsness et al, 2009; vom Saal and Hughes, 2005). …”

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confidence: 99%

Bisphenol-A exposure during adolescence leads to enduring alterations in cognition and dendritic spine density in adult male and female rats

Bowman

Luine

Weinstein

et al. 2015

Hormones and Behavior

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We have previously demonstrated that adolescent exposure of rats to bisphenol-A (BPA), an environmental endocrine disrupter, increases anxiety, impairs spatial memory, and decreases dendritic spine density in the CA1 region of the hippocampus (CA1) and medial prefrontal cortex (mPFC) when measured in adolescence in both sexes. The present study examined whether the behavioral and morphological alterations following BPA exposure during adolescent development are maintained into adulthood. Male and female, adolescent rats received BPA, 40 µg/kg/bodyweight, or control treatments for one week. In adulthood, subjects were tested for anxiety and locomotor activity, spatial memory, non-spatial visual memory, and sucrose preference. Additionally, stress-induced serum corticosterone levels and dendritic spine density in the mPFC and CA1 were measured. BPA-treated males, but not females, had decreased arm visits on the elevated plus maze, but there was no effect on anxiety. Non-spatial memory, object recognition, was also decreased in BPA treated males, but not females. BPA exposure did not alter spatial memory, object placement, but decreased exploration during the tasks in both sexes. No significant group differences in sucrose preference or serum corticosterone levels in response to a stress challenge were found. However, BPA exposure, regardless of sex, significantly decreased spine density of both apical and basal dendrites on pyramidal cells in CA1 but had no effect in the mPFC. Current data are discussed in relation to BPA dependent changes, which were present during adolescence and did, or did not, endure into adulthood. Overall, adolescent BPA exposure, below the current reference safe daily limit set by the U.S.E.P.A., leads to alterations in some behaviors and neuronal morphology that endure into adulthood.

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“…Biology and genetic endowment: Feeble biological construction (Chauhan et al, 2012;Robertson, Allen, Laney, & Curnow, 2013) and genetic vulnerability (Druzhinin et al, 2015;Madas & Varga, 2014) make some people more susceptible to adverse environmental outcomes than others. Likewise, individuals with robust immunity are less affected than those with weak or hypersensitive immune systems (Lin et al, 2004).…”

Section: Review Outcomesmentioning

confidence: 99%

An Interdisciplinary Population Health Approach to Radon Health Risk Management in Canada

Khan

Gomes

2018

RISS-IJHS

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Résumé :(traduction)Le radon est un cancérigène qui se retrouve dans l'air intérieur et qui existe en quantités supérieures au niveau de référence du gouvernement fédéral (200 Bq/ m3) dans environ dix pour cent des foyers canadiens. Le cancer du poumon provoqué par le radon tue plus de 3 000 personnes chaque année, ce qui représente 16 pour cent des décès annuels causés par le cancer du poumon au Canada. Le radon est la cause principale des décès attribués au cancer du poumon chez les non-fumeurs et la deuxième chez les fumeurs. Les enfants, les femmes et les fumeurs issus de groupes à faible revenu sont touchés de façon disproportionnée. Bien que le gouvernement fédéral ait réajusté le niveau de référence de 600 Bq/ m 3 à 200 Bq/m 3 et que les gouvernements provinciaux aient révisé les codes de construction pour limiter l'exposition, les dernières avancées scientifiques pour adopter des stratégies de gestion du radon au Canada demeurent controversées.Cette analyse se sert d'une approche intégrée axée sur la santé de la population pour examiner les relations et les interactions entre les déterminants de la santé de la population, tels que la biologie, la génétique, l'environnement, la profession, et les facteurs socioéconomiques qui influencent le risque du radon pour la santé. Les données recueillies et les politiques analysées en appliquant les principes éthiques et les principes de la gestion des risques ont mené à l'identification de stratégies de prévention efficaces, abordables à grande échelle et au niveau de la population. Les conclusions servent à améliorer la santé de la population en proposant des modalités d'intervention cruciales pour le Programme national sur le radon de Santé Canada. Mots-clés :Radon, risque pour la santé publique, déterminants de la santé, principes de la santé de la population, approche interdisciplinaire 33 Abstract:Radon is a known carcinogen found in indoor air that exists at higher than the federal reference level (200 Bq/m3) in about 10% of Canadian homes. Every year, over 3,000 people die from radon-induced lung cancer, which accounts for 16% of annual lung cancer deaths in Canada. Radon is the leading cause of lung cancer deaths among nonsmokers and is second among smokers. Children, women, and smokers from lower income groups are disproportionately affected. Although the Federal Government has reset the guideline (from the previous 600 Bq/m 3 down to 200 Bq/m 3 ) and provincial governments revised the building codes to limit exposure, there remain controversies with the latest scientific development in adopting strategies of radon management in Canada.This review applies an Integrated Population Health Framework to look at the relationships and interactions between population health determinants such as biology and genetics, environment and occupation, and social and economic factors, that influence the health risk of radon. The evidence gathered supports policy analysis with the application of ethical and risk management principles that lead to the identification of eff...

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Biological effects of alpha particle radiation exposure on human monocytic cells

Cited by 26 publications

References 56 publications

The Cellular and Molecular Carcinogenic Effects of Radon Exposure: A Review

The Cellular and Molecular Carcinogenic Effects of Radon Exposure: A Review

Bisphenol-A exposure during adolescence leads to enduring alterations in cognition and dendritic spine density in adult male and female rats

An Interdisciplinary Population Health Approach to Radon Health Risk Management in Canada

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