2001
DOI: 10.2486/indhealth.39.84
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Biological Effects of Asbestos Fibers on Human Cells In Vitro. Especially on Lymphocytes and Neutrophils.

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Cited by 10 publications
(16 citation statements)
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“…[25] Superoxide dismutases are oxidative-stress response enzymes: Mn-SOD expression is increased in rat lung epithelial cells after asbestos-fiber inhalation [46] and in vitro treatment of human lymphocytes with SOD inhibited cell death due to previous crocidolite incubation. [47] In this respect, mammals and fungal cells seem to have developed a homologous reaction in the presence of asbestos fibers.…”
Section: Discussionmentioning
confidence: 99%
“…[25] Superoxide dismutases are oxidative-stress response enzymes: Mn-SOD expression is increased in rat lung epithelial cells after asbestos-fiber inhalation [46] and in vitro treatment of human lymphocytes with SOD inhibited cell death due to previous crocidolite incubation. [47] In this respect, mammals and fungal cells seem to have developed a homologous reaction in the presence of asbestos fibers.…”
Section: Discussionmentioning
confidence: 99%
“…We have been investigating the immunological abnormalities found in silicosis patients focusing on the Fas-mediated apoptotic pathway [10,11], because of disorders in Fas and related molecules which have been reported in autoimmune diseases such as SLE and rheumatoid arthritis [12][13][14][15]. Our previous studies using clinical samples such as serum and mRNA from peripheral blood mononuclear cells (PBMCs) derived from patients with silicosis who were workers of brickyards in Bizen city and Hinase town, Okayama prefecture, Japan, demonstrated that dysregulation of the Fas gene, such as elevated serum soluble the Fas levels, led to dominantly expressed alternatively spliced variants of the Fas messages including soluble Fas as compared with the membrane Fas message, and elevated levels of decoy receptor 3 (DcR3) message, which functions similarly to soluble Fas [16][17][18].…”
Section: Introductionmentioning
confidence: 99%
“…We have previously reported that asbestos may act on peripheral T cells as a superantigen [22][23][24]. The effects of a superantigen, such as staphylococcal enterotoxin B (SEB), may modify TCRVb on peripheral T cells to enhance multiple, but not clonal, TCRVb expression [25][26][27][28].…”
Section: T Cell Receptor (Tcr)vb Expressionmentioning
confidence: 99%