Biological Effects of Estrogen on Skin

Phuong, Christina; Maibach, Howard I.

doi:10.1007/978-3-642-27814-3_35-2

Cited by 1 publication

(4 citation statements)

References 61 publications

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“…During reproductive years, the major estrogen produced by the ovaries is 17β-estradiol, which peaks in the late 20s (Figure 4A and B). 10,15,85 During a similar interval, expression of skin collagen and elastin also reach their maximum levels. 10,15,85 As estrogen levels begin to decline, around 30-35 years of age, the skin thins and folds or wrinkles appear due to the loss of collagen and elastin fibers in the dermal layer (Figure 4A).…”

Section: Skin Collagen and Elastin Profiles With Changes In 17beta-es...mentioning

confidence: 93%

“…10,15,85 During a similar interval, expression of skin collagen and elastin also reach their maximum levels. 10,15,85 As estrogen levels begin to decline, around 30-35 years of age, the skin thins and folds or wrinkles appear due to the loss of collagen and elastin fibers in the dermal layer (Figure 4A). 85 After 35 years of age, 17β-estradiol levels continue to decline and by 45 years of age there are high and low erratic swings in ovarian estrogen production as the follicles respond to gonadotrophins signals until they become exhausted with the onset of menopause (which the average in the USA is 51 years of age ± 4 years).…”

Section: Skin Collagen and Elastin Profiles With Changes In 17beta-es...mentioning

confidence: 93%

“…10,[81][82][83][84] Finally, estrogens: a) increase blood flow, b) enhance the expression of ERβ after menopause, c) stimulates transforming factor-beta (TGFβ), d) counteracts androgen hormone actions and photo-aging, and e) enhances facial attractiveness and perceived age in women. 10,15,61,65,75,78,85…”

Section: Benefits Of 17beta-estradiol In Skin Healthmentioning

confidence: 99%

“…10,15,85 As estrogen levels begin to decline, around 30-35 years of age, the skin thins and folds or wrinkles appear due to the loss of collagen and elastin fibers in the dermal layer (Figure 4A). 85 After 35 years of age, 17β-estradiol levels continue to decline and by 45 years of age there are high and low erratic swings in ovarian estrogen production as the follicles respond to gonadotrophins signals until they become exhausted with the onset of menopause (which the average in the USA is 51 years of age ± 4 years). 10,86 Concurrent with the loss of 17β-estradiol production from the ovaries at menopause estrogen production in the body occurs at peripheral adipose tissue sites.…”

Section: Skin Collagen and Elastin Profiles With Changes In 17beta-es...mentioning

confidence: 99%

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Factors Influencing Skin Aging and the Important Role of Estrogens and Selective Estrogen Receptor Modulators (SERMs)

Lephart¹,

Naftolin²

2022

CCID

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The narrative for this overview focuses on updating the factors that influence skin aging and the important role estrogens and selective estrogen receptor modulators (SERMs) play in this process (mainly utilizing journal reports and reviews from the last four years). Estrogens have been known and studied for over a century. For many years, it has been recognized that estrogens are important in the maintenance of human skin. Women seek cosmetic and medical treatments to improve dermal health and physical characteristics to enhance their self-perception and inhibit skin aging, particularly in highly visible body areas. The goal: to retain estrogen’s positive benefits while aging and especially at/after menopause where estrogen-deficient skin contributes to the dramatic decline in skin health. In this overview, both background information and recent novel findings are included that cover aging (general mechanisms), skin aging, and factors that influence skin aging (intrinsic, extrinsic, skin microbiome and gut microbiome.) Plus, estrogen’s general role in maintaining skin health is presented through the classical estrogen receptors alpha (α) and beta (β) and non-classical (or non-genomic) estrogen receptor (G protein-coupled seven transmembrane receptor). More importantly, the various benefits of 17β-estradiol in skin health are examined (ie, skin collagen and elastin profiles that follow 17β-estradiol levels during aging and at/after menopause). Finally, a revision of information for estrogenic skin topical applications involving isoflavonoid compounds that act as SERMs, but are classified as endocrine disruptors, and a topical estrogen analog are explored to update the known and unknown characteristics of these treatments. Further study is warranted to understand the biological and molecular mechanisms by which estrogens support and enhance dermal health and wellbeing.

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Section: Skin Collagen and Elastin Profiles With Changes In 17beta-es...mentioning

confidence: 93%

Section: Skin Collagen and Elastin Profiles With Changes In 17beta-es...mentioning

confidence: 93%

Section: Benefits Of 17beta-estradiol In Skin Healthmentioning

confidence: 99%

Section: Skin Collagen and Elastin Profiles With Changes In 17beta-es...mentioning

confidence: 99%

See 2 more Smart Citations

Factors Influencing Skin Aging and the Important Role of Estrogens and Selective Estrogen Receptor Modulators (SERMs)

Lephart¹,

Naftolin²

2022

CCID

View full text Add to dashboard Cite

show abstract

Biological Effects of Estrogen on Skin

Cited by 1 publication

References 61 publications

Factors Influencing Skin Aging and the Important Role of Estrogens and Selective Estrogen Receptor Modulators (SERMs)

Factors Influencing Skin Aging and the Important Role of Estrogens and Selective Estrogen Receptor Modulators (SERMs)

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