Biological effects of imidazolium ionic liquids with varying chain lengths in acute Vibrio fischeri and WST-1 cell viability assays

Ranke, Johannes; Mölter, Kerstin; Stock, Frauke; Bottin‐Weber, Ulrike; Poczobutt, Joanna M.; Hoffmann, Jens; Ondruschka, Bernd; Filser, Juliane; Jastorff, Bernd

doi:10.1016/s0147-6513(03)00105-2

Cited by 564 publications

(285 citation statements)

References 23 publications

Supporting

Mentioning

248

Contrasting

Unclassified

Order By: Relevance

“…This phenomenon is known as chemical hormesis, which is characterised by low-dose stimulation and high-dose inhibition (17). A similar hormetic effect of 1-n-octylmethylimidazolium tetrafl uoroborate [C 8 6 ], which is consistent with the results reported by Ranke et al (18).…”

Section: Discussionsupporting

confidence: 88%

Cytotoxic Effects of Imidazolium Ionic Liquids on Fish and Human Cell Lines

Cvjetko

Radošević

Tomica

et al. 2012

Archives of Industrial Hygiene and Toxicology

View full text Add to dashboard Cite

Ionic liquids bring a promise of a wide range of "green" applications that could replace conventional volatile solvents. However, before these applications become large-scale, their toxicity needs to be investigated in order to predict the impact on human health and environment. In this study we assessed the cytotoxicity of imidazolium ionic liquids (in the concentrations between 0.1 mmol L -1 and 10 mmol L -1 ) in the ovarian fi sh cell line CCO and the human tumour cell line HeLa using the MTT cell viability assay. Our results showed that the most cytotoxic ionic liquid was 1-n-butyl-3-methylimidazolium bis(trifl uoro methylsulphonyl)imide, [BMIM][Tf 2 N], followed by 1-n-butyl-3-methylimidazolium tetrafl uoroborate [BMIM] [BF 4 ], 1-n-butyl-3-methylimidazolium hexafluorophosphate [BMIM] [PF 6 ], and 1,3-dimethylimidazolium hexafl uorophosphate [MMIM] [PF 6 ]. Generally, the effects were concentrationdependent. They also depended on the type of anion and the n-alkyl chain length. The comparison between the fi sh CCO and human HeLa cell lines suggests that CCO cells provide a good biological system for initial toxicity testing of ionic liquids that could replace in vivo bioassays.

show abstract

Section: Discussionsupporting

confidence: 88%

Cytotoxic Effects of Imidazolium Ionic Liquids on Fish and Human Cell Lines

Cvjetko

Radošević

Tomica

et al. 2012

Archives of Industrial Hygiene and Toxicology

View full text Add to dashboard Cite

show abstract

“…22,25 We estimated the cytotoxicities of pyrridinium and piperidinium ionic liquids and they fall in the same range as imidazolium ionic liquids. 25,27 In addition, we observed that the toxicities of pyrridinium and piperidinium ionic liquids increase with an increase in the alkyl chain length, similar to that of imidazolium ionic liquids (Fig. 6b) [Br] -is twice as low as that for NaBr.…”

Section: Discussionmentioning

confidence: 55%

“…There has been sufficient interest in the recent past on toxic effects of ionic liquids on microorganisms 24,27,28 and on mammalian cells. 22,25 We estimated the cytotoxicities of pyrridinium and piperidinium ionic liquids and they fall in the same range as imidazolium ionic liquids.…”

Section: Discussionmentioning

confidence: 99%

“…There is growing interest in cytotoxicities, in aqueous environmental impact as well as in structureactivity relationship for ILs. [17][18][19][20][21][22][23][24][25][26][27][28] Only few reports have used human cancer cells. 18,22,26 For extraction of organic solutes or offensive metallic cations from water, we require highly hydrophobic ionic liquids that have very low solubility in water.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Physicochemical properties and toxicities of hydrophobic piperidinium and pyrrolidinium ionic liquids

Salminen

Papaïconomou

Kumar

et al. 2007

Fluid Phase Equilibria

175

View full text Add to dashboard Cite

show abstract

“…Recently, RTILs have been designed from nontoxic GRAS components such as saccharin and acesulfame [49]. Moreover, recent studies suggest that RTILs are generally orders of magnitude less toxic than conventional organic solvents [50]. Once the toxicity issue is better addressed, the application of ILs in the medical research will be inevitable.…”

Section: Toxicitymentioning

confidence: 99%

Ionic Liquids in Carbohydrate Chemistry—Current Trends and Future Directions

Murugesan

Linhardt

2006

ChemInform

View full text Add to dashboard Cite

Room Temperature Ionic Liquids (RTILs) have recently been introduced as new solvents in the chemical and biotechnological arenas. Carbohydrates are important natural products that play important biological and commercial roles as foods, drugs and chemical feedstocks. They have two properties that complicate their use a low solubility in most solvents and complex, highly chiral structures. We are currently witnessing a rapid increase in novel applications for newly discovered RTILs. This account reviews the application of RTILs in carbohydrate chemistry and biochemistry as a mono / biphasic solvent, a solvent / catalyst and a product retrieval media.

show abstract

Biological effects of imidazolium ionic liquids with varying chain lengths in acute Vibrio fischeri and WST-1 cell viability assays

Cited by 564 publications

References 23 publications

Cytotoxic Effects of Imidazolium Ionic Liquids on Fish and Human Cell Lines

Cytotoxic Effects of Imidazolium Ionic Liquids on Fish and Human Cell Lines

Physicochemical properties and toxicities of hydrophobic piperidinium and pyrrolidinium ionic liquids

Ionic Liquids in Carbohydrate Chemistry—Current Trends and Future Directions

Contact Info

Product

Resources

About