Biological effects of inorganic phosphate: potential signal of toxicity

Hong, Sun; Park, Sung Jin; Lee, Somin; Kim, Sanghwa; Cho, Myung‐Haing

doi:10.2131/jts.40.55

Cited by 33 publications

(22 citation statements)

References 101 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The authors noted a variety of nutrients were present in cystic GBM fluid at similar or higher levels than in CSF. Particularly, glutamate, lactate and inorganic phosphate, which was significantly higher than in CSF, were all found in cystic GBM fluid and have been shown previously to act in a similar manner to growth factors for tumor cells [16][17][18][19][20][21]. These results suggest that cystic fluid could act as a nutrient resource for GBM.…”

Section: Discussionsupporting

confidence: 70%

Assessment of Prognostic Value of Cystic Features in Glioblastoma Relative to Sex and Treatment with Standard-of-Care

Curtin

Whitmire

Rickertsen

et al. 2019

Preprint

View full text Add to dashboard Cite

Glioblastoma (GBM) is the most aggressive primary brain tumor and can have cystic components, identifiable through magnetic resonance imaging (MRI). Previous studies suggest that cysts occur in 7-23% of GBMs and report mixed results regarding their prognostic impact. Using our retrospective cohort of 493 patients with first-diagnosis GBM, we carried out an exploratory analysis on this potential link between cystic GBM and survival. Using pretreatment MRIs, we manually identified 88 patients with GBM that had a significant cystic component at presentation and 405 patients that did not. Patients with cystic GBM had significantly longer overall survival and were significantly younger at presentation. Within patients who received the current standard of care (SOC) (N=184, 40 cystic), we did not observe a survival benefit of cystic GBM. Unexpectedly, we did not observe a significant survival benefit between this SOC cystic cohort and patients with cystic GBM diagnosed before the standard was established (N=40 with SOC, N=19 without SOC); this significant SOC benefit was clearly observed in patients with noncystic GBM (N=144 with SOC, N=111 without SOC). When stratified by sex, this significant survival benefit was only preserved in male patients (N=303, 47 cystic). We report differences in the absolute and relative sizes of imaging abnormalities on MRI and the prognostic implication of cysts based on sex. We discuss hypotheses for these differences, including the possibility that the presence of a cyst could indicate a less aggressive tumor.Methods: Using pretreatment MRIs, we manually identified 88 patients with GBM that had a significant cystic component at presentation. Results: Compared to patients with noncystic GBM (N=405), patients with cystic GBM had significantly longer overall survival and were significantly younger at presentation. However, among patients who received the current standard-of-care treatment, cystic GBM (N=40) was not significant for outcome. We also did not observe a significant survival benefit when comparing this standard-of-care cystic cohort to patients with cystic GBM diagnosed before the standard was established (N=19), but the analogous result for patients with noncystic GBM gives a sizeable benefit, as expected (N=144, N=111, respectively). We also report differences in the absolute and relative sizes of imaging abnormalities on MRI and the prognostic implication of cysts based on sex. Conclusion: Together, these results may explain later studies that note no significant survival benefit for patients with cystic GBM receiving current standard-of-care. We discuss hypotheses for these observed differences, including the possibility that the presence of a cyst could indicate a less aggressive tumor.

show abstract

Section: Discussionsupporting

confidence: 70%

Assessment of Prognostic Value of Cystic Features in Glioblastoma Relative to Sex and Treatment with Standard-of-Care

Curtin

Whitmire

Rickertsen

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

“…Phosphates are added extensively in it to improve functional properties, such as increasing water holding capacity, reducing cook loss, maintaining texture and colour (Nguyen et al ., ). However, phosphate might cause the formation of a translucent, slimy texture and adulteration when added excessively (Kaewmanee et al ., ), and even induce hyperphosphatemia or lead to adverse cardiovascular effects after long‐term consumption of phosphates (Willhite et al ., ; Hong et al ., ). Accordingly, it is very necessary to develop alternative additives that are more efficient and healthier to replace the phosphates.…”

Section: Introductionmentioning

confidence: 97%

Protein hydrolysates of salted duck egg white improve the quality of Jinga Shrimp (Metapenaeus affinis)

Yang

Wang

Zhao

et al. 2017

Int J of Food Sci Tech

View full text Add to dashboard Cite

Summary The influence of protein hydrolysates of salt duck egg white (PHSDEW) hydrolysed by acid protease on the quality of Jinga Shrimp (Metapenaeus affinis) was analysed. Shrimp immersed in 5% PHSDEW with degree of hydrolysis (DH 3%) had the highest values of cooking yield, water retention, moisture and texture with the lowest cooking loss when compared to which immersed in 0.4% NaCl, 3.5% mixed phosphates and other PHSDEW with different DH (1%, 2% and 5%) (P < 0.05). This treatment made muscle fibres retain the most appropriate compact and regular microstructure and improved the thermal stability of shrimp protein as well (P < 0.05). SDS‐PAGE protein patterns revealed shrimp protein would dissolve out during immersion, while only could PHSDEW infiltrate into shrimp muscle. It suggested PHSDEW would be developed as a new type of water retention agent replaced phosphate used in shrimp or other seafoods, which will decrease the waste of salt duck egg white.

show abstract

“…It is also found in soft tissue (14%), blood (0.3%), and extravascular fluid (0.3%). The inorganic form exists either as free inorganic phosphate ions, or complexed with calcium, magnesium, or sodium [3,4].…”

Section: Introductionmentioning

confidence: 99%

Inorganic Phosphate Effect of on Human Dental Pulp Cell Cultures

Chou¹

2019

IJMSA

View full text Add to dashboard Cite

This study was designed to investigate the effect of inorganic phosphate (Pi) at different concentrations on odontogenesis of the normal human dental pulp cells (hDPCs). Normal human dental pulp cells derived from extracted pristine teeth were cultured in growth medium with supplements of inorganic phosphate (Pi) in 0 ppm, 2 ppm, 4 ppm, 5 ppm and 8 ppm, for the time intervals of 16 hours, 7, 14, and 21 days. Cell proliferation rates were measured by the optical density of crystal violet dye stained cells. ALP activity was measured by fluorometric assay. Expression of Dentin Sialoprotein (DSP) was measured by ELISA. The data were presented as the mean of triplicates. Statistical analysis was conducted using JMP Pro 12 (ver. 12.1.0) in one-way ANOVA and Tukey HSD post-hoc tests. Cell attachment efficiency was reduced significantly by additional Pi of 2, 4 and 5 ppm (P<0.05). At 21 days, cultures with 2, 4 and 5 ppm supplemental Pi displayed significantly higher cell proliferation rates compared to the control group at day 14 (P<0.05) and at day 21 (P<0.05). At day 7, cultures with 2, 4, 5 and 8 ppm supplemental Pi yield significantly higher levels of ALP activity (P<0.05) compared to the control group. At day 7, cultures with 5 ppm Pi supplement showed significantly higher levels of DSP expression (P<0.05) compared to the control group and the rest of the other groups. Supplemental Pi in concentration of 5 ppm could significantly induce proliferation and odontogenesis of hDPCs. This is the first report to demonstrate Pi-induced odontogenesis, leading to potential development and clinical application of future Pi containing dental pulp capping or root canal filling materials.

show abstract

Biological effects of inorganic phosphate: potential signal of toxicity

Cited by 33 publications

References 101 publications

Assessment of Prognostic Value of Cystic Features in Glioblastoma Relative to Sex and Treatment with Standard-of-Care

Assessment of Prognostic Value of Cystic Features in Glioblastoma Relative to Sex and Treatment with Standard-of-Care

Protein hydrolysates of salted duck egg white improve the quality of Jinga Shrimp (Metapenaeus affinis)

Inorganic Phosphate Effect of on Human Dental Pulp Cell Cultures

Contact Info

Product

Resources

About