Biological effects of schisandra chinensis medicines and prospects of their use in clinical medicine (literature review)

Abstract

Introduction. The constant action of harmful factors, increased levels of neuropsychological stress and stress-associated decline in immunity increase scientific interest for studying the therapeutic properties of phytoadaptogens. In particular, the study of preventive use of drugs based on the adaptogen of oriental traditional medicine – schisandra (Schisandra chinensis) is now gaining relevance. The aim of the study. To analyze modern scientific sources of literature on the main characteristics and use of Schisandra chinensis, to identify the dominant biological effects and prospects for the use of adaptogen in the prevention and treatment of disorders of the nervous system. Materials and methods. The analyzed literature was searched using the following electronic databases: PubMed, Medline, ResearchGate and Google Scholar. Results. This review demonstrates a wide range of effects of S. chinensis chemical components on the activity of various human organ systems. Based on the available data, it was found that the antitumor, antioxidant and anti-inflammatory pharmacological effects of chinese magnolia-vine have been actively studied. Special attention was paid to the psychophysiological properties of adaptogens, in particular S. chinensis. Experimental use of S. chinensis in mice with neurodegenerative disorders has shown an improvement in animal mental activity. Clinical trials of adaptogenic drugs with a high content of chinese magnolia-vine components have shown improved cognitive activity, speed and accuracy of movement in tired people, although in the literature there are cases when the consumption of mixtures did not show the desired results. Conclusions. The analysis of literature data confirms the prospects of using S. chinensis as a mean of prophylactic treatment in clinical medicine. However, despite the large amount of scientific research on the adaptogenic potential of chinese magnolia, the results of S. chinensis influence on human cognitive abilities are contradictory and need further study in the future.