Biological efficacy of novel metal complexes of Nitazoxanide: Synthesis, characterization, anti-COVID-19, antioxidant, antibacterial and anticancer activity studies

Sharfalddin, Abeer A.; Alyounis, Enas Inas Muta'eb; Emwas, Abdul‐Hamid; Jaremko, Mariusz

doi:10.1016/j.molliq.2022.120808

Cited by 12 publications

(3 citation statements)

References 41 publications

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“…Manganese complex, in particular, showed excellent antibacterial activity against S. aureus , comparison with the free ligand with an MIC value of 6.25 μg/mL. This result is probably due to the lipophilic nature of the metal ion in complexes which subsequently favor its permeation through the lipid layer of the cell membrane [58] . In addition, this behavior can be explained in terms of stability constants.…”

Section: Introductionmentioning

confidence: 90%

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Synthesis, Characterization and Biological Properties of Mn (II) and Cu (II) Complexes with Sulfonamide and Imidazole Derivatives: Genotoxicity, ADME Profile, and Molecular Docking Studies**

Bouchoucha,

Amine Bourouai,

Si Larbi

et al. 2023

ChemistrySelect

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The synthesis, characterization, and comparative biological properties of manganese (II) and copper (II) complexes formed with two heterocyclic ligands used in the pharmaceutical field are reported. The characterization of the metal complexes involved elemental analysis, FAB mass spectroscopy, ESR, FTIR, UV‐Visible spectroscopy, and conductometry. The spectroscopic data allowed the determination of the coordination mode and the geometry of all the coordination compounds.

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Section: Introductionmentioning

confidence: 90%

“…This result is probably due to the lipophilic nature of the metal ion in complexes which subsequently favor its permeation through the lipid layer of the cell membrane. [58] In addition, this behavior can be explained in terms of stability constants. The manganese complex is less stable than the copper one.…”

Section: Antibacterial and Antifungal Activitymentioning

confidence: 99%

Synthesis, Characterization and Biological Properties of Mn (II) and Cu (II) Complexes with Sulfonamide and Imidazole Derivatives: Genotoxicity, ADME Profile, and Molecular Docking Studies**

Bouchoucha,

Amine Bourouai,

Si Larbi

et al. 2023

ChemistrySelect

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“…Among these mentioned complexes, [Ni(NTZ)(CH 3 COO)(OH 2 )]·CH 3 COO had improved toxicity against Gram-positive Staphylococcus aureus. Our previous work describing the coordination of NTZ with the novel metals Ru(III), Au(III), and Ag (I) demonstrated increased biological potency of the organic ligand when combined with the metal ion [ 14 ]. Both Ru(III) and Au(III) complexes showed practical antioxidant and anticancer activities, but the Ag (I) complex showed the greatest inhibition of Gram-negative Escherichia coli .…”

Section: Introductionmentioning

confidence: 99%

Investigating the Biological Potency of Nitazoxanide-Based Cu(II), Ni(II) and Zn(II) Complexes Synthesis, Characterization and Anti-COVID-19, Antioxidant, Antibacterial and Anticancer Activities

Sharfalddin,

Al-Younis,

Emwas

et al. 2023

Molecules

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In this work, the biological potency of nitazoxanide (NTZ) was enhanced through coordination with transition metal ions Cu(II), Ni(II), and Zn(II). Initially, complexes with a ligand-metal stoichiometry of 2:1 were successfully synthesized and characterized by spectroscopic techniques and thermogravimetric methods. Measurement of the infrared spectrum revealed the bidentate nature of the ligand and excluded the possibility of the metal ion—amide group interaction. Nuclear magnetic resonance spectra showed a reduction in the NH- intensity signal and integration, indicating the possibility of enolization and the formation of keto-enol tautomers. To interpret these results, density functional theory was utilized under B3LYP/6-311G** for the free ligand and B3LYP/LANL2DZ for the metal complexes. We used UV-Vis and fluorescence spectroscopy to understand the biological properties of the complexes. This showed stronger interactions of NTZ-Cu(II) and NTZ-Ni(II) with DNA molecules than the NTZ-Zn(II) compound, with a binding constant (Kb) for the copper complex of 7.00 × 105 M−1. Both Cu(II)- and Ni(II)-NTZ had functional binding to the SARS-CoV-2 (6LU7) protease. Moreover, all metal complexes showed better antioxidation properties than the free ligand, with NTZ-Ni(II) having the best IC50 value of 53.45 μg/mL. NTZ-Ni(II) was an effective antibacterial, with a mean inhibitory concentration of 6 μM, which is close to that of ampicillin (a reference drug). The metal complexes had moderated anticancer potencies, with NTZ-Cu(II) having IC50 values of 24.5 and 21.5 against human breast cancer cells (MCF-7) and cancerous cervical tumor cells (HeLa), respectively. All obtained complexes exhibited high selectivity. Finally, the metal ions showed a practical role in improving the biological effectiveness of NTZ molecules.

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Synthesis, structural characterization, DNA/HSA binding, molecular docking and anticancer studies of some D-Luciferin complexes

Alshaikh¹,

Zaki²,

Sharfalddin³

et al. 2023

Arabian Journal of Chemistry

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Biological efficacy of novel metal complexes of Nitazoxanide: Synthesis, characterization, anti-COVID-19, antioxidant, antibacterial and anticancer activity studies

Cited by 12 publications

References 41 publications

Synthesis, Characterization and Biological Properties of Mn (II) and Cu (II) Complexes with Sulfonamide and Imidazole Derivatives: Genotoxicity, ADME Profile, and Molecular Docking Studies**

Synthesis, Characterization and Biological Properties of Mn (II) and Cu (II) Complexes with Sulfonamide and Imidazole Derivatives: Genotoxicity, ADME Profile, and Molecular Docking Studies**

Investigating the Biological Potency of Nitazoxanide-Based Cu(II), Ni(II) and Zn(II) Complexes Synthesis, Characterization and Anti-COVID-19, Antioxidant, Antibacterial and Anticancer Activities

Synthesis, structural characterization, DNA/HSA binding, molecular docking and anticancer studies of some D-Luciferin complexes

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