Biological enhancement of bone healing with Bone Morphogenetic Protein-7 at the clinical setting of pelvic girdle non-unions

Giannoudis, Peter V.; Psarakis, Spyridon A; Kanakaris, Nikolaos K.; Pape, Hans-Christian

doi:10.1016/s0020-1383(08)70008-1

Cited by 62 publications

(36 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our treatment approach was based on current evidence that autograft contains osteoprogenitor cells and osteoinductive factors and also provides some osteoconductive scaffolding properties [17,31] and on the hypothesis that BMP-7 may enhance the osteoinductive capacity of the ABG [9,23,27,38]. In patients with bone defects, the concept was to use BMP-7 as a powerful osteoinductive agent and the ABG as a graft expander.…”

Section: Discussionmentioning

confidence: 99%

“…In patients with bone defects, the concept was to use BMP-7 as a powerful osteoinductive agent and the ABG as a graft expander. Previous authors have reported the results of either ABG [20,41,50] or recombinant human BMP-7 [15,18,23,27,33,54] in isolation. Currently the existing clinical reports regarding the healing of atrophic nonunions with the use of BMPs have provided substantial arguments in favor of these agents ( Table 3).…”

Section: Discussionmentioning

confidence: 99%

“…They have been tested in various experimental animal nonunion models [32,39]. Since the FDA approval of BMP-7 for the treatment of recalcitrant tibial nonunions in 2001, its efficacy has been verified in a number of randomized trials [5,18,27] and large clinical series [12,15,23,26,33,38] with healing rates ranging from 81% to 92%.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Synergistic Effect of Autograft and BMP-7 in the Treatment of Atrophic Nonunions

Giannoudis

Kanakaris

Dimitriou

et al. 2009

Clin Orthop Relat Res

Self Cite

118

View full text Add to dashboard Cite

Combining autologous bone graft and recombinant human bone morphogenetic protein-7 (BMP-7) to treat long-bone fracture aseptic atrophic nonunions theoretically could promote bone healing at higher rates than each of these grafting agents separately. We retrospectively reviewed prospectively collected data on patient general characteristics, clinical outcomes, and complications over 3 years to determine the healing rates and the incidence of complications and adverse events of this ''graft expansion rationale.'' There were 45 patients (32 male) with a median age of 43 years (range, 19-76 years). Minimum followup was 12 months (mean, 24.5 months; range, 12-65 months). There were seven humeral, 19 femoral, and 19 tibial nonunions. The median number of prior operations was two (range, 1-7). All fractures united. Clinical and radiographic union occurred within a median of 5 months (range, 3-14 months) and 6 months (range, 4-16 months), respectively. Thirty-nine (87%) patients returned to their preinjury occupation at a mean of 4.2 months (range, 3-6 months). The median visual analog scale pain score was 0.9 (range, 0-2.8; maximum 10), and the median functional score was 86 (range, 67-95; maximum 100) at the final followup. BMP-7 as a bone-stimulating agent combined with conventional autograft resulted in a nonunion healing rate of 100% in these 45 patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Synergistic Effect of Autograft and BMP-7 in the Treatment of Atrophic Nonunions

Giannoudis

Kanakaris

Dimitriou

et al. 2009

Clin Orthop Relat Res

Self Cite

118

View full text Add to dashboard Cite

show abstract

“…The level of evidence of these studies was IV (retrospective/prospective uncontrolled case series [12,16,25,39,42,43,47,51,59,67] or case reports [1, 4, 6, 11, 17-19, 31, 32, 40, 46, 50, 61, 68, 69]). Four hundred thirtyseven patients were included for the final analysis (Table 1).…”

Section: Methodsmentioning

confidence: 99%

“…It was recorded as anterior, posterior, or simultaneously at both areas, nonradicular, activity-related, or disabling at various levels (from restricting pain at the extremes of the range of motion of the hips [4], sitting discomfort [39,42,47,51,69], dyspareunia, and sexual problems of mechanical origin [1,19,25,42,59] to bed confinement for patients with continuous debilitating pain [18,25,42,43,47,51]). Nonunions of the anterior elements could be pain-free [4,31,50] in contrast to those of the posterior elements in which they were mostly symptomatic [39,42,51].…”

Section: Clinical Manifestations Of Pelvic Malunion/nonunionsmentioning

confidence: 99%

Treatment and Outcomes of Pelvic Malunions and Nonunions: A Systematic Review

Kanakaris

Angoules

Nikolaou

et al. 2009

Clinical Orthopaedics &Amp; Related Research

Self Cite

View full text Add to dashboard Cite

Although acute management of pelvic fractures and their long-term functional outcome have been widely documented, important information regarding malunion and nonunion of these fractures is sparse. Despite their relative rarity, malunions and nonunions cause disabling symptoms and have major socioeconomic implications. We analyzed the factors predisposing a pelvic injury to develop malunion/nonunion, the clinical presentation of these complications, and the efficacy of the reported operative protocols in 437 malunions/nonunions of 25 clinical studies. Treatment of these demanding complications appeared effective in the majority of the cases: overall union rates averaged 86.1%, pain relief as much as 93%, patient satisfaction 79%, and return to a preinjury level of activities 50%. Nevertheless, the patient should be informed about the incidence of perioperative complications, including neurologic injury (5

show abstract

Orthobiologics

Axelrad¹,

Einhorn²

2011

Evidence‐Based Orthopedics

View full text Add to dashboard Cite

Biological enhancement of bone healing with Bone Morphogenetic Protein-7 at the clinical setting of pelvic girdle non-unions

Cited by 62 publications

References 25 publications

The Synergistic Effect of Autograft and BMP-7 in the Treatment of Atrophic Nonunions

The Synergistic Effect of Autograft and BMP-7 in the Treatment of Atrophic Nonunions

Treatment and Outcomes of Pelvic Malunions and Nonunions: A Systematic Review

Orthobiologics

Contact Info

Product

Resources

About