Biological Evaluation of 4’-(2-Thienyl)-2, 2’; 6’, 2”-terpyridine-1,1”-diium Chloride Tetrachloridoaurate (III): The Effect of Countercations

Kharat, Ali Nemati; Foroutannejad, Sahar; Khavasi, Hamid Reza

doi:10.1080/15533174.2011.615074

Cited by 4 publications

(2 citation statements)

References 12 publications

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“…Remarkable antibacterial and antifungal activity comparable to the standard drugs was found for tetrachloridoaurate(III) complex having protonated thioterpy (4′-(2-thienyl)-2,2′:6′,2″terpyridine) as the counter-cation. 59…”

Section: Antibacterial and Antifungal Gold(iii) Complexesmentioning

confidence: 99%

Gold complexes as antimicrobial agents: an overview of different biological activities in relation to the oxidation state of the gold ion and the ligand structure

2014

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Interest in antimicrobial gold complexes originated from the work of Robert Koch at the end of 19th century, who demonstrated that potassium dicyanidoaurate(I), K[Au(CN)2], showed activity against Mycobacterium tuberculosis, a causative agent of tuberculosis. Subsequently, a large number of gold(I) and gold(III) complexes have been evaluated as possible antimicrobial agents against a broad spectrum of bacteria, fungi and parasites. The first part of the present review article summarizes the results achieved in the field of antibacterial and antifungal activity of gold(I) and gold(III) complexes. The represented gold(I) complexes have been divided into three distinct classes based on the type of coordinated ligand: (i) complexes with phosphine-type ligands, (ii) complexes with N-heterocyclic carbene ligands and (iii) various other gold(I) complexes, while the results related to the antibacterial and antifungal gold(III) complexes have been mainly focused on the organometallic-type of complexes. The second section of this article represents findings obtained from the evaluation of antimalarial activity of gold complexes against chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum parasite. Antimalarial gold(I) and gold(III) complexes have been divided into the following classes, based on the nature of the coordinated ligand: (i) complexes with chloroquine and its derivatives, (ii) complexes with N-heterocyclic carbene ligands, (iii) complexes containing functionalised alkynes and (iv) thiosemicarbazonato ligands, as well as (v) other gold(I) and gold(III) complexes. In the last section of the review, gold(I) and gold(III) complexes have been reported to be potential agents against parasites that cause amoebiasis, leishmaniasis and trypanosomiasis. A systematic summary of these results could contribute to the future design of new gold(I) and gold(III) complexes as potential antimicrobial agents.

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Section: Antibacterial and Antifungal Gold(iii) Complexesmentioning

confidence: 99%

Gold complexes as antimicrobial agents: an overview of different biological activities in relation to the oxidation state of the gold ion and the ligand structure

2014

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“…This was observed by comparing the antimicrobial activity of a Au(III) complex containing a quinolone ligand—a nalidix complex ([Au(nix)(Cl) 2 ]) with the Ca(II), Fe(III), and Pd(II) analog complexes, standard drugs (tetracycline and amphotericin B), and the free ligand [ 87 ]. Other gold complexes that were described as displaying remarkable antibacterial activity were the tetrachloroaurate (III) complex [(H 2 thioterpy)Cl(AuCl 4 )] and the bisdithiolate Au(III) complexes [NBu 4 ][Au(cdc) 2 ] (where cdc = cyanodithioimidocarbonate), [PPh 4 ][Au(qdt) 2 ] (where qdt = quinoxaline-2,3-dithiolate), and [NEt 4 ][Au(Et-thiazdt) 2 ] (where thiazdt = N -alkyl-1,3-thiazoline-2-thione dithiolate) [ 88 , 89 , 90 ]. The bisdithiolate Au(III) complexes tested were only active against Gram-positive bacteria.…”

Section: Antimicrobial Alternatives Under Investigationmentioning

confidence: 99%

Bacterial Nosocomial Infections: Multidrug Resistance as a Trigger for the Development of Novel Antimicrobials

et al. 2021

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Nosocomial bacterial infections are associated with high morbidity and mortality, posing a huge burden to healthcare systems worldwide. The ongoing COVID-19 pandemic, with the raised hospitalization of patients and the increased use of antimicrobial agents, boosted the emergence of difficult-to-treat multidrug-resistant (MDR) bacteria in hospital settings. Therefore, current available antibiotic treatments often have limited or no efficacy against nosocomial bacterial infections, and novel therapeutic approaches need to be considered. In this review, we analyze current antibacterial alternatives under investigation, focusing on metal-based complexes, antimicrobial peptides, and antisense antimicrobial therapeutics. The association of new compounds with older, commercially available antibiotics and the repurposing of existing drugs are also revised in this work.

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New supramolecular metallo-terpyridine carboxymethyl cellulose derivatives with antimicrobial properties

Hassan

Moorefield

et al. 2015

Carbohydrate Polymers

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Biological Evaluation of 4’-(2-Thienyl)-2, 2’; 6’, 2”-terpyridine-1,1”-diium Chloride Tetrachloridoaurate (III): The Effect of Countercations

Cited by 4 publications

References 12 publications

Gold complexes as antimicrobial agents: an overview of different biological activities in relation to the oxidation state of the gold ion and the ligand structure

Gold complexes as antimicrobial agents: an overview of different biological activities in relation to the oxidation state of the gold ion and the ligand structure

Bacterial Nosocomial Infections: Multidrug Resistance as a Trigger for the Development of Novel Antimicrobials

New supramolecular metallo-terpyridine carboxymethyl cellulose derivatives with antimicrobial properties

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