Biological Evaluation of Azo‐ and Imino‐Based Carboxylate Triphenyltin(IV) Compounds

Abstract

Azo (‐N=N‐)‐ and imino (‐C=N‐)‐carboxylate triphenyltin(IV) compounds, which are well known for their promising biological activities, are usually synthesized by reacting a triphenyltin(IV) compound (oxide, hydroxide or chloride) with a suitably substituted carboxylic acid, under appropriate conditions. Their biological properties are influenced by the type/position of the functional azo or imino group in the carboxylate ligand skeleton. They are very effective in anticancer studies, being often better than the standard drug cisplatin in terms of cytotoxicity. A few of the azo‐appended carboxylate triphenyltin(IV) compounds also display anti‐bacterial, anti‐fungal and anti‐diabetic activities. The present manuscript highlights the syntheses, structures, and biological (i.e., anti‐cancer, anti‐bacterial, anti‐fungal and anti‐diabetic) activities of such triphenyltin(IV) compounds.

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