Biological Evaluation of Hot-Melt Extruded Nano-selenium and the Role of Selenium on the Expression Profiles of Selenium-Dependent Antioxidant Enzymes in Chickens

Lee, JunHyung; Hosseindoust, Abdolreza; Kim, Min-Ju; Kim, KwangYeol; Choi, Youngin; Lee, SeokHee; Lee, Song Yi; Cho, HyunJong; Kang, Wei Soo; Chae, B. J.

doi:10.1007/s12011-019-01801-8

Cited by 20 publications

(12 citation statements)

References 29 publications

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“…Sophora koreensis has been known as a traditional herb to treat rheumatoid issues in Korea because of its antioxidant capacity [ 13 , 24 ]. The antioxidant enzymes including SOD, GPx, and catalase are the first factors against antioxidant reactions [ 11 , 12 ]. Antioxidant effects of scopoletin were shown earlier [ 16 , 17 ].…”

Section: Discussionmentioning

confidence: 99%

“…Normally, the natural antioxidant defense system is able to prevent cells from oxidative injuries by enzymatic control of free radicals [ 10 ]. Superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase are the major enzymes to counteract free radicals and diminish the lipid peroxidation rates [ 11 , 12 ]. In addition, the lower antioxidant defense in the body results in the excessive generation of ROS leading to oxidative injuries [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

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Effects of Scopoletin Supplementation and Stocking Density on Growth Performance, Antioxidant Activity, and Meat Quality of Korean Native Broiler Chickens

Kang

Hosseindoust

et al. 2021

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Stocking density stress is one of the most common management stressors in the poultry industry. The present study was designed to investigate the effect of dietary Sophora koreensis (SK; 0 and 20 mg/kg diet) and stocking density (SD; 14 and 16 chickens/m2) on the antioxidant status, meat quality, and growth performance of native Korean chickens. There was a lower concentration of malondialdehyde (MDA) and a higher concentration of catalase, superoxide dismutase (SOD), and total antioxidant capacity in the serum and leg muscle with the supplementation of SK. The concentration of MDA was increased and concentrations of SOD were decreased in the leg muscle of chickens in low SD treatments. The SK-supplemented treatments showed an increased 3-ethylbenzothiazoline-6-sulfonate-reducing activity of leg muscles. The higher water holding capacity of breast muscle and a lower cooking loss and pH were shown in the SK-supplemented treatments. The addition of dietary SK resulted in a greater body weight gain and greater spleen and bursa Fabricius weight, as well as lower feed intake and abdominal fat. The low SD and supplementation of SK increased the concentrations of cholesterol. The concentration of glucose was increased in the low SD treatment. Corticosterone level was decreased in the SK-supplemented and low SD treatments. In conclusion, SK supplementation reduced the oxidative stress and increased meat quality and antioxidant status of chickens apart from the SD stress.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of Scopoletin Supplementation and Stocking Density on Growth Performance, Antioxidant Activity, and Meat Quality of Korean Native Broiler Chickens

Kang

Hosseindoust

et al. 2021

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“…The antimicrobial properties of high levels of CuSO 4 have also well documented [4,8,9]. However, continuous use of trace elements in high doses as growth stimulators causes environmental issues concerning the high mineral salts content in poultry wastes [2,10]. There are ongoing studies aimed at finding proper options to maximize the growth performance, particularly that the growth performance of broiler chickens has been dramatically increased because of the genetically improved species.…”

Section: A C C E T E D Introductionmentioning

confidence: 99%

Effects of hot-melt extruded nano-copper on the Cu bioavailability and growth of broiler chickens

et al. 2021

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This study was aimed to investigate the Cu bioavailability, growth response, digestibility of nutrients, and blood metabolites of broiler chicks fed CuSO 4 in nano or common forms. A total of 720 broiler chickens were distributed between eight treatments according to a completely randomized design. There were 8 treatments and 6 replicates in each treatment with 15 birds/replicate. The treatments were divided into common copper sulfate at the doses of 16 ppm, 40 ppm, 80 ppm, and 120 ppm (INO) and hot-melt extruded copper sulfate at the doses of 16 ppm, 40 ppm, 80 ppm, and 120 ppm (HME-Cu). The experiment was operated for 35 days in 2 phases (phase 1, d 0 to 14; and phase 2, d 15 to 35). No significant differences were shown in growth performance, feed intake, FCR, and nutrient digestibility among the treatments. The concentration of Cu in the serum was increased in the HME-Cu broilers compared with the INO broilers at phase 2. A linear increase was observed in the concentration of Cu in the liver in broilers fed INO diets, however, no significant differences were observed by the supplementation of HME-Cu levels. The linear increase was detected in the content of Cu in excreta in the INO and HME-Cu treatments by increasing the dietary Cu content. The HME-Cu treatments showed a lower Cu concentration in the excreta compared with the INO treatments. The higher bioavailability of Cu in HME form can decrease the recommended dose of Cu in broiler diets.

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“…In addition, HME-Cu increased the Cu content of the liver compared to the control, and reduced the Cu content of the feces compared to the IN-Cu-supplemented diets. Our previous studies reported that HME improved the bioavailability and metabolic function of minerals, which in turn decreased the fecal mineral output in weanling pigs and broiler chickens [23,24,25,26,27,28]. Similarly, in chickens, diet supplementation with 20 mg/kg of inorganic and organic Cu increased the Cu content of their liver; and in weanling pigs, diet supplementation with 50 mg/kg of nano-Cu reduced their fecal Cu content compared to diet supplementation with 50 mg/kg of inorganic Cu [41,52].…”

Section: A C C E P T E D a R T I C L Ementioning

confidence: 98%

“…Previous studies showed that HME-processed trace elements had the reduced particle size to nano by the addition of pharmaceutical excipients in order to increase the solubility and dispersion of trace elements [21,22]. Our previous studies have shown the improved bioavailability and metabolic function of HME-processed trace minerals in weanling pigs and broilers [23,24,25,26,27,28]. To evaluate the extent of the nano-process effect on minerals bioavailability in broiler chickens many studies are required, particularly that there are insufficient reports about these technologies at present.…”

Section: Introductionmentioning

confidence: 99%

Hot-melt extruded copper sulfate affects the growth performance, meat quality, and copper bioavailability of broiler chickens

et al. 2022

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Objective: This study was conducted to evaluate the effects of the supplementation of diets of broiler chickens with hot-melt extruded CuSO 4 (HME-Cu) on their growth performance, nutrient digestibility, gut microbiota, small intestinal morphology, meat quality, and copper (Cu) bioavailability.Methods: A total of 225 broilers (Ross 308), one-day old and initial weight 39.14 g, were weighed and distributed between 15 cages (15 birds per cage) in a completely randomized experimental design with 3 treatments (diets) and 5 replicates per treatment. Cages were allotted to three treatments including control (without supplemental Cu), IN-Cu (16 mg/kg of CuSO 4 ), and HME-Cu (16 mg/kg of HME processed CuSO 4 ). Results: The HME-Cu treatment tended to increase the overall body weight gain (BWG) (p<0.10). The apparent digestibility of Cu was increased by supplementation of HME-Cu at phase 2 (p<0.05). The Escherichia coli (E. coli) count in cecum tended to decrease with the supplementation with Cu (p<0.10). In addition, the HME-Cu treatment had a higher pH of breast meat than the control and IN-Cu treatments (p<0.05). Significant increases in the cooking loss (CL), water-holding capacity (WHC), and lightness in the breast were observed in the HME-Cu treatment compared to the control (p<0.05). The Cu content of excreta increased with the Cu supplementation (p<0.05). The concentration of excreta Cu in broilers was decreased in the HME-Cu compared to the IN-Cu in phase 2 (p<0.05). The Cu concentration in the liver was increased with the HME-Cu supplementation, compared with the control diets (p<0.05). Conclusion:This study showed that HME-Cu supplementation at the requirement level (16 mg/kg diets) in broiler diets did not affect the growth performance and the physiological function of Cu in broilers. However, supplementation of Cu in HME form improved the meat quality and the bioavailability of Cu.

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Biological Evaluation of Hot-Melt Extruded Nano-selenium and the Role of Selenium on the Expression Profiles of Selenium-Dependent Antioxidant Enzymes in Chickens

Cited by 20 publications

References 29 publications

Effects of Scopoletin Supplementation and Stocking Density on Growth Performance, Antioxidant Activity, and Meat Quality of Korean Native Broiler Chickens

Effects of Scopoletin Supplementation and Stocking Density on Growth Performance, Antioxidant Activity, and Meat Quality of Korean Native Broiler Chickens

Effects of hot-melt extruded nano-copper on the Cu bioavailability and growth of broiler chickens

Hot-melt extruded copper sulfate affects the growth performance, meat quality, and copper bioavailability of broiler chickens

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