Biological evaluation of Phellinus linteus-fermented broths as anti-inflammatory agents

Lin, Chun Jung; Lien, Hsiu-Man; Chang, Hsiao-Yun; Huang, Chao-Lu; Liu, Jau-Jin; Chang, Yun-Chieh; Chen, Chia-Chang; Lai, Chih‐Ho

doi:10.1016/j.jbiosc.2014.01.001

Cited by 22 publications

(15 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among these components, hispolon is among the most crucial functional compounds [Fig. (A)], and has been reported to possess antioxidant, antiinflammatory, and antiproliferative activities (Yang et al, ; Lin et al, ). Recently, the antitumor effects of this phenolic compound have been demonstrated in the cell lines of various cancers.…”

Section: Introductionmentioning

confidence: 99%

Hispolon suppresses migration and invasion of human nasopharyngeal carcinoma cells by inhibiting the urokinase‐plasminogen activator through modulation of the Akt signaling pathway

Hsieh

et al. 2016

Environmental Toxicology

View full text Add to dashboard Cite

Hispolon has been reported to possess antioxidant, antiinflammatory, and antitumor activities. However, the effect of hispolon on the metastasis of nasopharyngeal carcinoma (NPC) remains unclear. In this study, we investigated how the antimetastatic activity and relevant signaling pathways of hispolon affected three NPC cell lines. The results revealed that hispolon significantly reduced the migration and invasion of three NPC cells in a dose-dependent manner from 0 to 50 µM. Hispolon also significantly inhibited the activity and expression of urokinase-plasminogen activator (uPA) as well as the phosphorylation of Akt. Moreover, blocking the Akt pathway also enhanced the antimetastatic ability of hispolon in the NPC cells. In conclusion, hispolon inhibited uPA expression and NPC cell metastasis by downregulating Akt signal pathways; therefore, hispolon exerts beneficial effects in chemoprevention. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 645-655, 2017.

show abstract

Section: Introductionmentioning

confidence: 99%

Hispolon suppresses migration and invasion of human nasopharyngeal carcinoma cells by inhibiting the urokinase‐plasminogen activator through modulation of the Akt signaling pathway

Hsieh

et al. 2016

Environmental Toxicology

View full text Add to dashboard Cite

show abstract

“…Previous studies showed that some Phellinus species such as P . linteus [ 21 , 25 , 26 ] and P . baumii [ 23 ] exert their anti-inflammatory effects through inhibiting the expression of nuclear factor-κB (NFκB) p65 and mitogen-activated protein kinases (MAPKs) (e.g., extracellular signal-regulated protein kinase (ERK) and p38).…”

Section: Discussionmentioning

confidence: 99%

The aqueous extract of Phellinus igniarius (SH) ameliorates dextran sodium sulfate-induced colitis in C57BL/6 mice

Sun

et al. 2018

PLoS ONE

View full text Add to dashboard Cite

Phellinus igniarius, which is called Sanghuang in Chinese, is a fungal herb widely used in Traditional Chinese Medicine to treat stomachache, inflammation and tumors. Recent studies have demonstrated the antitumor, anti-diabetic, anti-inflammatory and immunity-modulating activities of P. igniarius. In the present study, we investigated that ameliorating effect of the aqueous extract of P. igniarius fruiting body (SH) on dextran sodium sulfate (DSS)-induced colitis in C57BL/6 mice. Treatment with SH (250 and 400 mg/kg) for 8 weeks effectively alleviated the pathological indicators of colitis such as bodyweight reduction, disease activity index score, shortening of colon length and abnormal colon histology. The plasma levels of lipopolysaccharide (LPS) and inflammatory factors such as interleukin-6 (IL-6), IL-1β and tumor necrosis factor (TNF)-α were all significantly reduced. Supplementation of SH (10 mg/L) also inhibited LPS-elicited IL-1β production by RAW264.7 macrophages. Real-time PCR and western blot showed that treatment with SH significantly inhibited the phosphorylation of nuclear factor kappa B inhibitor alpha (IκBα) and decreased the expression of IL-6/IL-1β-maturation genes such as apoptosis-associated speck-like protein (ASC3) and caspase-1 in the colon of DSS-induced colitis mice. These results suggest that SH is adequate for the treatment of colitis. Inhibiting the expression and release of inflammatory factors may participate in the colitis-ameliorating effect of SH.

show abstract

“…Adverse effects associated with non-steroidal anti-inflammatory drugs (NSAIDs) arouse the need to develop safe alternatives for the treatment of chronic inflammations ( Sostres et al, 2010 ). Hispolon induces potent anti-inflammatory response by suppressing TNF-α (tumor necrosis factor-α) ( Lin et al, 2014 ), and decreasing MMP-9 via inhibition of NF-κB pathway ( Sun et al, 2015 ). Anti-inflammatory actions of hispolon occur via inhibition of JNK phosphorylation ( Yang et al, 2014 ).…”

Section: Biological Activities Of Hispolonmentioning

confidence: 99%

Hispolon: A natural polyphenol and emerging cancer killer by multiple cellular signaling pathways

Sarfraz

Rasul

Sarfraz

et al. 2020

Environmental Research

View full text Add to dashboard Cite

Nature as an infinite treasure of chemotypes and pharmacophores will continue to play an imperative role in the drug discovery. Natural products (NPs) such as plant and fungal metabolites have emerged as leads in drug discovery during recent years due to their efficacy, safety and selectivity. The current review summarizes natural sources as well as pharmacological potential of hispolon which is a major constituent of traditional medicinal mushroom Phellinus linteus . The study aims to update the scientific community about recent developments of hispolon in the arena of natural drugs by providing insights into its present status in therapeutic pursuits. Hispolon, a polyphenol has been reported to possess anticancer, antidiabetic, antioxidant, antiviral and anti-inflammatory activities. It fights against cancer via induction of apoptosis, halting cell cycle and inhibition of metastasis by targeting various cellular signaling pathways including PI3K/Akt, MAPK and NF-κB. The current review proposes that hispolon provides a novel opportunity for pharmacological applications and its styrylpyrone carbon skeleton might serve as an attractive scaffold for drug development. However, future researches are recommended to assess bioavailability, toxicological limits, pharmacokinetic and pharmacodynamic profiles of hispolon, in order to establish its potential as a potent multi-targeted drug in the near future.

show abstract

Biological evaluation of Phellinus linteus-fermented broths as anti-inflammatory agents

Cited by 22 publications

References 32 publications

Hispolon suppresses migration and invasion of human nasopharyngeal carcinoma cells by inhibiting the urokinase‐plasminogen activator through modulation of the Akt signaling pathway

Hispolon suppresses migration and invasion of human nasopharyngeal carcinoma cells by inhibiting the urokinase‐plasminogen activator through modulation of the Akt signaling pathway

The aqueous extract of Phellinus igniarius (SH) ameliorates dextran sodium sulfate-induced colitis in C57BL/6 mice

Hispolon: A natural polyphenol and emerging cancer killer by multiple cellular signaling pathways

Contact Info

Product

Resources

About