Biological evaluation of ultra-fine titanium with improved mechanical strength for dental implant engineering

Ostrovska, Lucie; Vištějnová, Lucie; Džugan, Ján; Sláma, Peter; Kubina, Tomáš; Ukraintsev, Egor; Kubies, Dana; Králíčková, Milena; Kalbáčová, Marie Hubálek

doi:10.1007/s10853-015-9619-3

Cited by 23 publications

(13 citation statements)

References 40 publications

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“…In concordance with our results [ 16 ], Thirugnanam et al [ 17 ] found significantly higher adhesion of osteoblasts and increased bone formation on nanostructured titanium surfaces when compared to conventional titanium. Since that time, many in vitro as well as in vivo studies have investigated the impact of nanostructured surfaces on the behavior of the surrounding cells [ 18 , 19 ]. Zhou et al [ 20 ] suggested one possible explanation, based on changes in the chemical composition of titanium surface immersed in a simulated body fluid (SBF) with an addition of bovine serum albumin (BSA).…”

Section: Introductionmentioning

confidence: 99%

Proliferation of Osteoblasts on Laser-Modified Nanostructured Titanium Surfaces

et al. 2018

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Nanostructured titanium has become a useful material for biomedical applications such as dental implants. Certain surface properties (grain size, roughness, wettability) are highly expected to promote cell adhesion and osseointegration. The aim of this study was to compare the biocompatibilities of several titanium materials using human osteoblast cell line hFOB 1.19. Eight different types of specimens were examined: machined commercially pure grade 2 (cpTi2) and 4 (cpTi4) titanium, nanostructured titanium of the same grades (nTi2, nTi4), and corresponding specimens with laser-treated surfaces (cpTi2L, cpTi4L, nTi2L, nTi4L). Their surface topography was evaluated by means of scanning electron microscopy. Surface roughness was measured using a mechanical contact profilometer. Specimens with laser-treated surfaces had significantly higher surface roughness. Wettability was measured by the drop contact angle method. Nanostructured samples had significantly higher wettability. Cell proliferation after 48 hours from plating was assessed by viability and proliferation assay. The highest proliferation of osteoblasts was found in nTi4 specimens. The analysis of cell proliferation revealed a difference between machined and laser-treated specimens. The mean proliferation was lower on the laser-treated titanium materials. Although plain laser treatment increases surface roughness and wettability, it does not seem to lead to improved biocompatibility.

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Section: Introductionmentioning

confidence: 99%

Proliferation of Osteoblasts on Laser-Modified Nanostructured Titanium Surfaces

et al. 2018

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“…7 The present study proposes a process route which involves CONFORM SPD forming and rotary swaging (RS) in order to enhance the mechanical properties of a workpiece. [8][9][10] The effects of severe plastic deformation and work hardening are thus combined. The proposed technology allows the mechanical properties of pure titanium to be improved dramatically.…”

Section: Introductionmentioning

confidence: 99%

Effect of severe plastic and heavy cold deformation on the structural and mechanical properties of commercially pure titanium

Palán¹,

Šutta²,

Kubina³

et al. 2017

Mater. Tehnol.

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SPD (severe plastic deformation) processing of materials provides a great potential associated with the enhancement of their properties by refining the initial grain structure. The present experiments involved mechanical working of commercial-purity titanium (Ti Grade 2) with the CONFORM SPD technique, which is one of the SPD methods, and with rotary swaging. The objective was to process the material at as low temperatures as possible in order to avoid softening processes and, therefore, to achieve the maximum strengthening through a microstructure refinement. Three passes through a CONFORM SPD machine were completed and the resulting ultimate strength was 673 MPa. The average grain size was 330 nm. The greatest improvement of the mechanical properties was achieved in the first pass. In the subsequent passes, the contributions were minor. The processing in the CONFORM SPD machine did not impair the ductility of the material. Subsequently, the wires were rotary swaged. The ultimate strength achieved was 1070 MPa. The response of the properties to this forming method was markedly different. The reason is that rotary swaging does not belong to SPD techniques. It causes rapid work hardening and reduces the ductility of the material. The workpiece was subsequently investigated with the aid of several techniques. Light and transmission electron microscopy and X-ray diffraction were employed for evaluating the grain size, distribution and orientation. Keywords: equal-channel angular pressing, CONFORM SPD technique, rotary swaging, titanium, extrusion Velika plasti~na deformacija (angl. SPD) pri obdelavi materialov omogo~a veliko mo`nosti, povezane z izbolj{anjem njihovih lastnosti z izbolj{avo izvorne strukture zrn. Pri~ujo~i preizkus je vklju~eval mehansko obdelavo komercialno dostopnega~istega titana (Ti Grade 2) s CONFORM SPD-tehniko, ki je ena od SPD-metod, in s kovanjem. Namen je bil, da bi se material obdelalo pri~im ni`jih temperaturah, kot je mogo~e, da bi se izognili procesom meh~anja in, da bi dosegli maksimalno krepitev s prei{~enjem strukture. Narejeni so bili trije nizi v CONFORM SPD-stroju in kon~na mo~je dosegla 673 MPa. Povpre~na velikost zrn je bila 330 nm. Najve~je izbolj{ave mehanskih lastnosti so bile dose`ene v prvem nizu. V slede~ih nizih so bile le-te manj{e. Obdelava v CONFORM SPD-stroju ni {kodovala duktilnosti materiala. Posledi~no so bile`ice zvite. Kon~na mo~je bila 1070 MPa. Odziv lastnosti na to metodo oblikovanja je bil izrazito druga~en. Razlog je v tem, da rotacijsko zvijanje ne sodi v tehnike SPD. Rotacijsko zvijanje povzro~i hitro utrjevanje in zmanj{uje duktilnost materiala. Vzorec je bil nato raziskan s pomo~jo vet ehnik. Za ovrednotenje velikosti, razporeditve in orientacije zrn, sta bili uporabljeni transmisijska elektronska mikroskopija in rentgenska difrakcija.

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“…Biological activation of metal implants is another important issue for biomedical product applications [ 64 , 65 , 66 , 67 ] because every metal implant combined/integrated with host tissues through a bioactive interface or layer. It was found that certain biomaterials can bond to living bone through an apatite layer that forms on surfaces after being implanted [ 68 ].…”

Section: Different Applications Of Metal Implants In Clinicmentioning

confidence: 99%

Bio-Functional Design, Application and Trends in Metallic Biomaterials

Zhou

Fan

et al. 2017

IJMS

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Introduction of metals as biomaterials has been known for a long time. In the early development, sufficient strength and suitable mechanical properties were the main considerations for metal implants. With the development of new generations of biomaterials, the concepts of bioactive and biodegradable materials were proposed. Biological function design is very import for metal implants in biomedical applications. Three crucial design criteria are summarized for developing metal implants: (1) mechanical properties that mimic the host tissues; (2) sufficient bioactivities to form bio-bonding between implants and surrounding tissues; and (3) a degradation rate that matches tissue regeneration and biodegradability. This article reviews the development of metal implants and their applications in biomedical engineering. Development trends and future perspectives of metallic biomaterials are also discussed.

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Biological evaluation of ultra-fine titanium with improved mechanical strength for dental implant engineering

Cited by 23 publications

References 40 publications

Proliferation of Osteoblasts on Laser-Modified Nanostructured Titanium Surfaces

Proliferation of Osteoblasts on Laser-Modified Nanostructured Titanium Surfaces

Effect of severe plastic and heavy cold deformation on the structural and mechanical properties of commercially pure titanium

Bio-Functional Design, Application and Trends in Metallic Biomaterials

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