Biological fabrication of Ag/Ag<sub>2</sub>O nanoparticles by<i>Haplophyllum obtusifolium</i>watery extract: characterisation and estimation of its biochemical activities

Rezaei, Mohammad Reza; Es‐haghi, Ali; Yaghmaei, Parichehreh; Ghobeh, Maryam

doi:10.1049/mnl.2020.0269

Cited by 10 publications

(7 citation statements)

References 48 publications

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“…The biosynthesis of NPs offers a perspective to expand their applications in many fields like biosensing, photocatalysis, medicine, and food industries [ 25 , 26 , 27 , 28 , 29 ]. Recently, interest in natural products has grown due to their benefits and low side effects [ 30 , 31 , 32 ].…”

Section: Introductionmentioning

confidence: 99%

Biosynthesis and characterisation of solid lipid nanoparticles and investigation of toxicity against breast cancer cell line

Sharifalhoseini

Es‐haghi

Vaezi

et al. 2021

IET Nanobiotechnology

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Solid lipid nanoparticles (SLNs) comprise non-toxic surface-active lipidic agents combined with appropriate ratios of drugs or essential oils. The goal of this research was to investigate the effects of the SLN synthesised using essential oils of Foeniculum vulgare on the MCF-7 breast cancer cell line. SLNs were prepared by homogenisation and ultrasound techniques and characterised by dynamic light scattering (DLS), zeta potential assessment, and transmission electron microscopy (TEM). 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay (MTT assay), flow-cytometry, and Acridine-Orange assay were employed for assessing the biological activities of the SLNs. The average particle size was 55.43 nm and the net surface charge was −29.54 ± 11.67 mV. TEM showed that the mean particle size was 33.55 nm and the synthesised SLNs had a uniform round morphology. The MTT assay showed that the prepared SLNs had high toxicity against MCF-7 cells and low toxicity against normal HUVECs cells. Flowcytometry revealed a noteworthy rise in the subG1 peak of the cell cycle in the cancer cells treated with SLNs compared to the controls, indicating apoptosis in cancer cells. The results also showed discolouration in SLNs-treated cells, which further confirmed the induction of apoptosis and the toxicity of the SLNs against MCF-7 cells.This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Section: Introductionmentioning

confidence: 99%

Biosynthesis and characterisation of solid lipid nanoparticles and investigation of toxicity against breast cancer cell line

Sharifalhoseini

Es‐haghi

Vaezi

et al. 2021

IET Nanobiotechnology

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“…The shape of the synthesized nanoparticles was spherical, and their mean diameter was 13 nm (Figure 1) (28). Polydispersity index values for nanoparticles were 0.28.…”

Section: Antibacterial Activitymentioning

confidence: 95%

“…Next, 10 mL of the aqueous extract was mixed with silver nitrate and stirred for 24 hours (27). A change of color into dark brown verified the synthesis of nanoparticles and the conversion of Ag + to Ag 0 (28).…”

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confidence: 99%

Assessment of Antioxidant and Antimicrobial Activities of Silver Nanoparticles Biosynthesized by Haplophyllum Obtusifolium

Rezaei

Es‐haghi

Yaghmaei

et al. 2020

Avicenna J Med Biochem

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Background: Plants comprise great antioxidant sources as a result of their redox and biochemical components, which are rich in secondary metabolites such as phenolic acids, flavonoids, and other constituents. Haplophyllum obtusifolium from polygonaceae is widely used for preventing and managing diabetes. This study investigated the antibacterial and antioxidant activities of silver nanoparticles (AgNPs) biosynthesized by H. obtusifolium. Methods: The aerial parts of H. obtusifolium were gathered from the north of Khorasan Razavi province, Iran and desiccated at the chamber temperature. The shoots were powdered by grinding, 5 g of the powder was mixed with 250 mL of deionized water, and the resultant blend was then filtered. Bactericidal properties and antioxidant activity of the nanoparticles were assessed using disk diffusion and DPPH (2, 2-diphenyl-1-picrylhydrazyl) tests, respectively. Results: The results of this study showed that the biosynthesized nanoparticles exhibited antibacterial activity against a gram-negative (Klebsiella pneumoniae) bacterium, but they had no effects on gram-positive Staphylococcus epidermidis. Antioxidant test results showed that these nanoparticles were capable of eliminating DPPH radicals in a concentration-dependent manner so that a more potent antioxidant activity was seen in higher concentrations of the nanoparticles. Conclusion: Our results suggested that H. obtusifolium can be used as a key source of antioxidants/ antimicrobial agents in food and pharmaceutical industries.

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“…Researchers were more interested in using plants to create nanoparticles for biological purposes [17][18][19][20]. The green approaches employ various capping agents based on plant extracts [21][22][23][24][25].…”

Section: Introductionmentioning

confidence: 99%

Biosynthesis of ZnO.Ag₂O₃ using aqueous extract of Haplophyllum obtusifolium: Characterization and cell toxicity activity against liver carcinoma cells

Abad

Nadaf

Yazdi

2023

Micro & Nano Letters

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The zinc oxide‐silver oxide nanocomposite (ZnO.Ag2O3 particles) was prepared by using an aqueous plant extract of Haplophyllum obtusifolium for the first time. Powder X‐ray diffraction (PXRD), Fourier transforms spectroscopy (FTIR), field emission microscopy (FESEM), energy dispersive X‐ray analysis (EDX), and transmission electron microscopy (TEM) were applied to analyze the structure, functional groups, morphology, and purity of the prepared nanocomposite. PXRD revealed the formulation of ZnO.Ag2O3 for the particles. The investigation of functional groups has demonstrated the presence of some carbonated impurities along with absorbed water in the composition of the ZnO.Ag2O3 nanocomposite. Morphologically, particles have formed a petal‐like shape with different sizes. The EDX analysis also confirmed the composition of the prepared sample and the presence of 4.78% silver in the formula. Additionally, the TEM analysis revealed spherical and rectangular shapes with a particle size of 80.43 ± 46.73 nm. Moreover, the ZnO.Ag2O3 particles were used against cancer cells, which has shown synthesized NCs have a toxic effect against liver cancer cells in a concentration and time‐dependent manner.

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Biological fabrication of Ag/Ag₂O nanoparticles byHaplophyllum obtusifoliumwatery extract: characterisation and estimation of its biochemical activities

Cited by 10 publications

References 48 publications

Biosynthesis and characterisation of solid lipid nanoparticles and investigation of toxicity against breast cancer cell line

Biosynthesis and characterisation of solid lipid nanoparticles and investigation of toxicity against breast cancer cell line

Assessment of Antioxidant and Antimicrobial Activities of Silver Nanoparticles Biosynthesized by Haplophyllum Obtusifolium

Biosynthesis of ZnO.Ag₂O₃ using aqueous extract of Haplophyllum obtusifolium: Characterization and cell toxicity activity against liver carcinoma cells

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Biological fabrication of Ag/Ag2O nanoparticles byHaplophyllum obtusifoliumwatery extract: characterisation and estimation of its biochemical activities

Cited by 10 publications

References 48 publications

Biosynthesis and characterisation of solid lipid nanoparticles and investigation of toxicity against breast cancer cell line

Biosynthesis and characterisation of solid lipid nanoparticles and investigation of toxicity against breast cancer cell line

Assessment of Antioxidant and Antimicrobial Activities of Silver Nanoparticles Biosynthesized by Haplophyllum Obtusifolium

Biosynthesis of ZnO.Ag2O3 using aqueous extract of Haplophyllum obtusifolium: Characterization and cell toxicity activity against liver carcinoma cells

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Biological fabrication of Ag/Ag₂O nanoparticles byHaplophyllum obtusifoliumwatery extract: characterisation and estimation of its biochemical activities

Biosynthesis of ZnO.Ag₂O₃ using aqueous extract of Haplophyllum obtusifolium: Characterization and cell toxicity activity against liver carcinoma cells