Biological Factors Involved in the Osseointegration of Oral Titanium Implants With Different Surfaces: A Pilot Study in Minipigs

Abstract

We observed that the levels of BMP-4 and TGF-beta1, which play essential roles in the osteogenesis process, increased earlier around the porous implants than around the machined implants. Similarly, the ossification process was initiated earlier at the surfaces of the porous implants than at the surfaces of the machined implants.

Colonization by human fibroblasts of polypropylene prosthesis in a composite form for hernia repair

“…This observation may be indirectly confirmed by the results of our previous study, showing that the surface properties of oral implants induce osteointegration differently: ossification begins later at the surface of machined implants than porous ones. Thus the presence of a nonsmooth surface allowed better colonization by cells [22].…”

Cytokines and Growth Factors Involved in the Osseointegration of Oral Titanium Implants Positioned Using Piezoelectric Bone Surgery Versus a Drill Technique: A Pilot Study in Minipigs

“…Porous implants were used because they were shown to be more efficient in stimulating osseointegration than machined implants 1‐5 . To monitor the osseointegration process, samples were collected at different post‐implant intervals (7, 14, and 56 days) from sites prepared using the Brånemark surgical drill or piezoelectric bone surgery technique.…”

“…To enhance peri‐implant osteogenesis and reduce the bone healing time after implant site preparation, the biologic factors that are involved in these processes must be evaluated. Literature supports the hypothesis that a porous implant surface is more effective in stimulating peri‐implant osteogenesis than is a machined one using traditional drilling 1‐5 . When bone formation was evaluated by histologic analysis, 5 levels of biologic factors, bone morphogenetic protein (BMP)‐4 and transforming growth factor (TGF)‐β, increased earlier around porous implants.…”

Bone ingrowth on the surface of endosseous implants. Part 1: Mathematical model

“…Among the different methods of surface modification, two of them stand out because of their current popularity. In first place, alterations in surface 3 A c c e p t e d m a n u s c r i p t microtopography are used to influence cell and tissue responses (Brunette, 1988;Hayakawa et al, 2002;Schierano et al, 2005). Secondly, biochemical modifications of the surface can also be designed with the aim of controlling the biological reaction at the interface by means of the delivery of specific molecules.…”