Biological features of human influenza A(H3N8) viruses in China

Zhu, W.-M.; Chen, Qi; Xu, Xiaohao; Wei, Hejiang; Tan, Min; Yang, Lei; Zou, Shumei; Li, Zi; Lin, Shudai; Wang, Dayan

doi:10.1002/jmv.28912

Cited by 9 publications

(4 citation statements)

References 21 publications

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“…Three studies reported very limited reactivity of human sera with novel reassortant H3N8 viruses. 1 , 7 , 30 In contrast, we found that about two-thirds of the human sera tested displayed microneutralization titres of ≥40 against A/Henan/2022 virus, especially sera from older donors. Chen et al.…”

Section: Discussionmentioning

confidence: 58%

Characterization of a human H3N8 influenza virus

Gu,

Fan,

Dahn

et al. 2024

eBioMedicine

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Section: Discussionmentioning

confidence: 58%

Characterization of a human H3N8 influenza virus

Gu,

Fan,

Dahn

et al. 2024

eBioMedicine

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“…No detectable antibodies against A(H3N8) virus were identified in individuals vaccinated against seasonal influenza viruses, suggesting a susceptible human population to A(H3N8) infection (Zhu et al, 2023). Seasonal influenza vaccines are not protective against A(H3N8) infection.…”

Section: A(h3n8)mentioning

confidence: 97%

“…In experimental infection of human lung and bronchial tissue ex vivo, the A(H3N8) virus replicated inefficiently, indicating it is unlikely to transmit effectively between humans (Hui et al, 2023). Inhibition studies suggest the two A(H3N8) viruses from humans in 2022 are sensitive to oseltamivir (Zhu et al, 2023).…”

Section: A(h3n8)mentioning

confidence: 99%

Avian influenza overview September–December 2023

Adlhoch,

Fusaro,

Gonzales

et al. 2023

EFS2

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Between 2 September and 1 December 2023, highly pathogenic avian influenza (HPAI) A(H5) outbreaks were reported in domestic (88) and wild (175) birds across 23 countries in Europe. Compared to previous years, the increase in the number of HPAI virus detections in waterfowl has been delayed, possibly due to a later start of the autumn migration of several wild bird species. Common cranes were the most frequently affected species during this reporting period with mortality events being described in several European countries. Most HPAI outbreaks reported in poultry were primary outbreaks following the introduction of the virus by wild birds, with the exception of Hungary, where two clusters involving secondary spread occurred. HPAI viruses identified in Europe belonged to eleven different genotypes, seven of which were new. With regard to mammals, the serological survey conducted in all fur farms in Finland revealed 29 additional serologically positive farms during this reporting period. Wild mammals continued to be affected mostly in the Americas, from where further spread into wild birds and mammals in the Antarctic region was described for the first time. Since the last report and as of 1 December 2023, three fatal and one severe human A(H5N1) infection with clade 2.3.2.1c viruses have been reported by Cambodia, and one A(H9N2) infection was reported from China. No human infections related to the avian influenza detections in animals in fur farms in Finland have been reported, and human infections with avian influenza remain a rare event. The risk of infection with currently circulating avian H5 influenza viruses of clade 2.3.4.4b in Europe remains low for the general population in the EU/EEA. The risk of infection remains low to moderate for occupationally or otherwise exposed people to infected birds or mammals (wild or domesticated); this assessment covers different situations that depend on the level of exposure.

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“…Studies have shown that H3N2 influenza in Hong Kong in 1968 was also due to recombination with the human H2N2 virus NA, PB2, PA, NP, M and NS genes, but the population does not have immunity to the new HA and NA, resulting in the rapid spread of the new virus, causing a human flu pandemic (Lindstrom et al, 2004). In April 2022, China notified the WHO of the world's first known human infection with the H3N8 subtype of avian influenza virus (Zhu et al, 2023).…”

Section: Introductionmentioning

confidence: 99%

Concern regarding H3-subtype avian influenza virus

Yu,

Yao,

Liu

et al. 2023

Front. Microbiol.

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The H3-subtype of avian influenza virus (AIV) is one of the most frequently detected low pathogenic avian influenza virus (LPAIV) subtypes in birds and fowls, causing substantial economic loss to the poultry industry. Most importantly, besides poultry, mammals could also be infected with it, such as swines, canines, equines, felines, and humans, posing a serious public health threat. This allows the virus to persist widely in poultry and wild birds for a long time, where it may mix with other subtypes, providing conditions for viral recombination or reassortment. Currently, the monitoring of H3-subtype AIV is inadequate, and there is a lack of effective prevention and control measures for H3-subtype AIV. Here, the epidemiology, phylogeny, and genetic variation of H3-subtype AIV were analyzed, and nonsynonymous and synonymous substitution rates (dN/dS) were calculated. Through these steps, we aimed to clarify the current epidemiological feature and evolutionary characteristics of H3-subtype AIV, and provide an operative reference for future scientific control of H3-subtype AIV.

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Biological features of human influenza A(H3N8) viruses in China

Cited by 9 publications

References 21 publications

Characterization of a human H3N8 influenza virus

Characterization of a human H3N8 influenza virus

Avian influenza overview September–December 2023

Concern regarding H3-subtype avian influenza virus

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