Biological Frailty Index in centenarians

Arosio, Beatrice; Geraci, Annalisa; Ferri, Evelyn; Mari, Daniela

doi:10.1007/s40520-021-01993-x

Cited by 10 publications

(7 citation statements)

References 14 publications

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“…A clinical FI is also able to significantly predict self-rated health and Instrumental Activities of Daily Living (IADL) dependency beyond the effect of age and gender in a cohort of Chinese centenarians 23 . Interestingly, in the Northern Italy cohort, a FI built on biological parameters showed average lower values (median value of 0.33) and a narrower distribution (from 0.11 to 0.69) than the clinical one 24 . The data observed in these centenarians are amazing, if we consider that in older persons the biological FI generally shows higher values than those of the clinical FI, since biological FI anticipates the changes in health status before the manifestation of the clinical deficits 25,26 .…”

Section: Frailty and Longevitymentioning

confidence: 88%

The heterogeneous approach to reach longevity: the experience of Italian centenarians

Arosio,

Ferri,

Mari

et al. 2024

JGG

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Section: Frailty and Longevitymentioning

confidence: 88%

The heterogeneous approach to reach longevity: the experience of Italian centenarians

Arosio,

Ferri,

Mari

et al. 2024

JGG

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“…Octogenarians, nonagenarians, and centenarians are special populations of older adults who escape the fate of usual aging and have increased biological reserves, but at the same time are exposed to an extremely high risk of frailty. Therefore, there have been attempts to develop frailty diagnostic instruments dedicated to long-lived individuals, including laboratory biomarkers of biological frailty [ 53 ].…”

Section: Discussionmentioning

confidence: 99%

Frailty and Survivability of Polish Caucasian Nonagenarians and Centenarians

Skubiszewska,

Broczek,

Maruniak-Chudek

et al. 2024

Geriatrics

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Frailty is a major geriatric problem leading to an increased risk of disability and death. Prevention, identification, and treatment of frailty are important challenges in gerontology and public health. The study aimed to estimate the prevalence of the frailty phenotype (FP) among the oldest-old Polish Caucasians and investigate the relationship between the FP and mortality. Baseline data were collected from 289 long-lived individuals, including 87 centenarians and 202 subjects aged 94–99. Mortality was obtained from population registers over the following 5 years. Sixty percent of subjects were classified as frail, 33% as prefrail, and 7% as robust. Frailty was more common in women than men and among centenarians than nonagenarians. During the 5-year observation period, 92.6% of the frail women and all frail men died, while mortality rates were lower among prefrail, 78.8% and 66.7%, and robust individuals, 60% and 54.5%, respectively. In the survival analysis, frailty was the strongest negative risk factor: HR = 0.328 (95% CI: 0.200–0.539). The inability to perform handgrip strength measurement was an additional predictor of short survival. In conclusion, the FP is prevalent in nonagenarians and centenarians and correlates with lower survivability. Future studies should address differences between unavoidable age-associated frailty and reversible disability in long-lived individuals.

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“…Environmental and lifestyle factors can have differential effects on the clinical profile and epigenetic status over the course of a person's life [23]. Consequently, as a result, long livers constitute a highly heterogeneous population, encompassing individuals in both good and very poor health statuses, as demonstrated by the varying degrees of frailty [24]. Several previous studies have explored the association between epigenetically determined age and frailty, and these studies have confirmed a strong link between prevalent frailty and epigenetic age [25].…”

Section: Discussionmentioning

confidence: 99%

Decelerated Epigenetic Aging in Long Livers

Guvatova,

Kobelyatskaya,

Pudova

et al. 2023

IJMS

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Epigenetic aging is a hot topic in the field of aging research. The present study estimated epigenetic age in long-lived individuals, who are currently actively being studied worldwide as an example of successful aging due to their longevity. We used Bekaert’s blood-based age prediction model to estimate the epigenetic age of 50 conditionally “healthy” and 45 frail long-livers over 90 years old. Frailty assessment in long-livers was conducted using the Frailty Index. The control group was composed of 32 healthy individuals aged 20–60 years. The DNA methylation status of 4 CpG sites (ASPA CpG1, PDE4C CpG1, ELOVL2 CpG6, and EDARADD CpG1) included in the epigenetic clock was assessed through pyrosequencing. According to the model calculations, the epigenetic age of long-livers was significantly lower than their chronological age (on average by 21 years) compared with data from the group of people aged 20 to 60 years. This suggests a slowing of epigenetic and potentially biological aging in long livers. At the same time, the obtained results showed no statistically significant differences in delta age (difference between the predicted and chronological age) between “healthy” long livers and long livers with frailty. We also failed to detect sex differences in epigenetic age either in the group of long livers or in the control group. It is possible that the predictive power of epigenetic clocks based on a small number of CpG sites is insufficient to detect such differences. Nevertheless, this study underscores the need for further research on the epigenetic status of centenarians to gain a deeper understanding of the factors contributing to delayed aging in this population.

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Biological Frailty Index in centenarians

Cited by 10 publications

References 14 publications

The heterogeneous approach to reach longevity: the experience of Italian centenarians

The heterogeneous approach to reach longevity: the experience of Italian centenarians

Frailty and Survivability of Polish Caucasian Nonagenarians and Centenarians

Decelerated Epigenetic Aging in Long Livers

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