Biological function of Foot-and-mouth disease virus non-structural proteins and non-coding elements

Gao, Yuan; Sun, Shiqi; Guo, Huichen

doi:10.1186/s12985-016-0561-z

Cited by 103 publications

(77 citation statements)

References 208 publications

(266 reference statements)

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“…One of the most likely explanations for lineage turnover is the acquisition of protective immunity against a certain lineage within exposed host populations, which nevertheless remain susceptible to new, emerging strains. However, changes in non‐structural proteins may also play a role in this process (Gao, Sun, & Guo, ; Pacheco, Henry, O'Donnell, Gregory, & Mason, ).…”

Section: Introductionmentioning

confidence: 99%

Dynamics of widespread foot‐and‐mouth disease virus serotypes A, O and Asia‐1 in southern Asia: A Bayesian phylogenetic perspective

Brito

Mohapatra

Subramaniam

et al. 2017

Transbound Emerg Dis

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Foot-and-mouth disease (FMD) is, arguably, the animal disease with the most devastating global economic impact owing in part, to the severe trade restrictions imposed upon affected countries and regions. South Asia is one of the regions where widespread lineages of the FMDV virus (FMDV) have emerged. Here, we performed an integrative phylogenetic analysis of all FMDV serotypes (A, O and Asia-1) circulating in southern Asia, including viral sequences collected until 2013. Our results describe the occurrence of FMD caused by different serotypes and lineages, focusing in the cycles where a specific lineage predominates within a region for a protracted period and then are rapidly or progressively replaced by an emergent or re-emergent strain that is introduced from an adjacent region. Transmission between the two main regions in southern Asia (the Indian subcontinent and the region comprised by Afghanistan, Iran and Pakistan) has been limited. Results of time divergence estimation of lineages that currently circulate in this region indicate that the most recent common ancestor of endemic lineages are: 1992 [1989-1995] for lineage O/PanAsia; 1997 [1995-1999] for PanAsia2; 2001 [1998-2004] for O/Ind2001; 2001 [2000-2002] for A/Iran-05; 1990 [1988-1991] for A/G-18 (G-VII); 2003 [2000-2006] for Asia-1 Sindh08 and 2002 [1999-2004] for Asia-1 G-VIII. We estimated the mean of the overall substitution rate of the VP1 coding region (substitution/site/year) for serotype O (5.95 × 10 ), serotype A (1.19 × 10 ) and serotype Asia-1 (3.08 × 10 ). The potential factors driving the lineage turnover are discussed. Our results provide insights into the ecological and evolutionary factors driving the emergence of FMDV.

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Section: Introductionmentioning

confidence: 99%

Dynamics of widespread foot‐and‐mouth disease virus serotypes A, O and Asia‐1 in southern Asia: A Bayesian phylogenetic perspective

Brito

Mohapatra

Subramaniam

et al. 2017

Transbound Emerg Dis

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“…FMDV, a positive-strand RNA virus in the Picornaviridae family (20), causes acute and persistent infections in host cells and cloven-hoofed animals (21)(22)(23). Cells coexist with virus without obvious cytopathic effects (CPE) and produce infectious virions during serial passage of BHK-21 cells persistently infected with FMDV (14,24).…”

mentioning

confidence: 99%

Single-Cell Analysis of the Impact of Host Cell Heterogeneity on Infection with Foot-and-Mouth Disease Virus

Xin

Wang

Han

et al. 2018

J Virol

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Viral infection and replication are affected by host cell heterogeneity, but the mechanisms underlying the effects remain unclear. Using single-cell analysis, we investigated the effects of host cell heterogeneity, including cell size, inclusion, and cell cycle, on foot-and-mouth disease virus (FMDV) infection (acute and persistent infections) and replication. We detected various viral genome replication levels in FMDV-infected cells. Large cells and cells with a high number of inclusions generated more viral RNA copies and viral protein and a higher proportion of infectious cells than other cells. Additionally, we found that the viral titer was 10- to 100-fold higher in cells in G/M than those in other cell cycle phases and identified a strong correlation between cell size, inclusion, and cell cycle heterogeneity, which all affected the infection and replication of FMDV. Furthermore, we demonstrated that host cell heterogeneity influenced the adsorption of FMDV due to differences in the levels of FMDV integrin receptors expression. Collectively, these results further our understanding of the evolution of a virus in a single host cell. It is important to understand how host cell heterogeneity affects viral infection and replication. Using single-cell analysis, we found that viral genome replication levels exhibited dramatic variability in foot-and-mouth disease virus (FMDV)-infected cells. We also found a strong correlation between heterogeneity in cell size, inclusion number, and cell cycle status and that all of these characteristics affect the infection and replication of FMDV. Moreover, we found that host cell heterogeneity influenced the viral adsorption as differences in the levels of FMDV integrin receptors' expression. This study provided new ideas for the studies of correlation between FMDV infection mechanisms and host cells.

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“…It has a catalytic component of RNA replication and plays an important role in the life cycle of FMDV. 3D pol sequences are highly conserved among different serotypes as well as subtypes of FMDV (Gao et al, 2016).…”

Section: Foot and Mouth Disease Virus Nonstructural Proteinsmentioning

confidence: 99%

Advances in structure-assisted antiviral discovery for animal viral diseases

Tomar

Mahajan

Kumar

2020

Genomics and Biotechnological Advances in Veterinary, Poultry, and Fisheries

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Biological function of Foot-and-mouth disease virus non-structural proteins and non-coding elements

Cited by 103 publications

References 208 publications

Dynamics of widespread foot‐and‐mouth disease virus serotypes A, O and Asia‐1 in southern Asia: A Bayesian phylogenetic perspective

Dynamics of widespread foot‐and‐mouth disease virus serotypes A, O and Asia‐1 in southern Asia: A Bayesian phylogenetic perspective

Single-Cell Analysis of the Impact of Host Cell Heterogeneity on Infection with Foot-and-Mouth Disease Virus

Advances in structure-assisted antiviral discovery for animal viral diseases

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