Biological Function of Placental Protein PP5 on Coagulation and Fibrinolytic Activities during Placental Separation

Soma, Hiroaki; Sayama, Shoko; Okudera, K; Isaka, Keiici; Takayama, Masaki

doi:10.1159/000411382

Cited by 3 publications

(3 citation statements)

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“…10 Since the original hemorrhage of IVT probably occurs through a rupture of the attenuated vasculo-syncytial membrane, such rupture is accompanied by the release of thromboplastin and by the formation of fibrin degradation products (FDP), thereby resulting in coagulation and fibrinolysis in this area. 11 On the other hand, plasminogen activator inhibitors (PAI-2) are produced by the trophoblast and released into the maternal blood, thereby responsible for the formation of microthrombi in the placentas. 12 It has been suggested that the formation of IVT may result in a deficient blood supply to the fetus followed by IUGR.…”

Section: Discussionmentioning

confidence: 99%

A Clinicopathological Aspect of Chorionic Villous Hemorrhage Leading to Formation of Intervillous Thrombosis

Soma¹,

Watanabe²,

Osawa³

et al. 1998

Semin Thromb Hemost

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Recently it was reported that chorionic villous hemorrhage (CVH) had a significant association with retroplacental hemorrhage (RPH). In this study, to determine whether CVH has a correlation with RPH or intervillous thrombosis (IVT), placentas associated with CVH were clinico-histopathologically investigated and compared to those with IVT. Obstetric complications in 32 cases with CVH were compared with 258 cases with IVT. Placental abruption was significantly higher (18.7%) in the CVH group than in the IVT group (5.03%) and the incidences of intrauterine fetal death (IUFD) as well as intrauterine growth retardation (IUGR) were also significantly higher (18.7% and 9.37%) in the CVH group than in the IVT group (3.10% and 2.32%). Of the pathological characteristics of the placentas with CVH, IVT was found in 46.8%, but marginal or retroplacental hemorrhages were seen in 34.3%, compared to 14.2% of the IVT group. Premature infants with low birth weight (under 2000 g) and before 36 weeks of gestation were born in 53.1% and 34.3% of cases with CVH placentas. CVH was not only located near the basal plate of the placentas and decidual hemorrhages, but was also highly associated with chorangiosis in 75% of cases. Using histological and ultrastructural studies in CVH cases, villous stroma was filled with fetal erythrocytes and leakage of blood cells was observed through a disruption of the trophoblast layer of hemorrhagic villi. In conclusion, it is suggested that CVH may rather be related to formation of the intervillous thrombosis than to RPH.

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Section: Discussionmentioning

confidence: 99%

A Clinicopathological Aspect of Chorionic Villous Hemorrhage Leading to Formation of Intervillous Thrombosis

Soma¹,

Watanabe²,

Osawa³

et al. 1998

Semin Thromb Hemost

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“…PP5 may be involved in the coagulation and fibrinolytic mechanism in normal and pathological placental separation [16][17][18]. If so, abnormally high PP5 levels in severe tox emia may forewarn of coagulation distur bances at the placenta where marked fibrin deposits and infarcts in the intervillous spaces are often observed, while the inci dence of low serum PP5 levels tended to be observed in mild toxemia where relatively less impairment of uteroplacental vessels and placenta was recognized [19].…”

Section: Discussionmentioning

confidence: 99%

Serum Concentration of Placental Proteins (PP5 and PP10) in Toxemia of Pregnancy as Related to Intrauterine Growth Retardation

Takayama¹,

Soma²,

Isaka³

et al. 1987

Gynecol Obstet Invest

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Maternal serum concentrations of placental proteins 5 (PP5) and 10 (PP10) were measured by radioimmunoassay in 568 samples obtained from 308 healthy pregnant women and 63 women having toxemia of pregnancy. Below-normal PP5 values were more widely distributed in the mild than in the severe toxemia group, while the incidence of above-normal PP5 values was found only in the severe toxemia group. The incidence of below-normal PP10 values was higher in the severe than in the mild toxemia group. Our study thus suggests that simultaneous measurement of PP5 and PP10 concentrations in maternal serum in toxemia of pregnancy is a useful monitoring technique for predicting progressive pathological change and placental dysfunction related to IUGR.

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“…The abnormally large placenta de scribed in this report was characterized by multiple hemangiomas and relatively high levels of placental proteins in the second tri mester. Because raised PP5 levels may be related to coagulation and fibrolytic activity in pathologic lesions such as abruptio placen tae [7], increased placental protein concentra tions, especially of PP5, in the serum may be ascribed to a formation of multiple heman giomas and thrombi in the intravillous spaces of the abnormally large placenta.…”

Section: Discussionmentioning

confidence: 99%

Abnormally Large Placenta Associated with Beckwith-Wiedemann Syndrome

Takayama¹,

Soma²,

Yaguchi³

et al. 1986

Gynecol Obstet Invest

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A 37-year-old G1-P1 was diagnosed by ultrasonography at 26 weeks of gestation as having an abnormally large placenta with hemangiomas and a fetus associated with exomphalos. Placental protein 5 levels were relatively high in placental protein levels in maternal serum. The infant, delivered by cesarean section at 34 weeks, had the typical clinical features associated with Beckwith-Wiedemann syndrome. The abnormally large placenta weighed 1,492 g, measured 25 × 25 × 5.1 cm, and featured multiple hemangiomas. Microscopic placental features included edematous villi, increased fibrin deposition, intervillous thrombi, and multiple angiomatous and cellular chorangiomas.

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Biological Function of Placental Protein PP5 on Coagulation and Fibrinolytic Activities during Placental Separation

Cited by 3 publications

References 0 publications

A Clinicopathological Aspect of Chorionic Villous Hemorrhage Leading to Formation of Intervillous Thrombosis

A Clinicopathological Aspect of Chorionic Villous Hemorrhage Leading to Formation of Intervillous Thrombosis

Serum Concentration of Placental Proteins (PP5 and PP10) in Toxemia of Pregnancy as Related to Intrauterine Growth Retardation

Abnormally Large Placenta Associated with Beckwith-Wiedemann Syndrome

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