Biological Glucose Metabolism Regulated Peptide Self‐Assembly as a Simple Visual Biosensor for Glucose Detection

Xu, Xiaoding; Lin, Bin; Feng, Jun; Wang, Ya; Cheng, Si‐Xue; Zhang, Xian‐Zheng; Zhuo, Ren‐Xi

doi:10.1002/marc.201100689

Cited by 65 publications

(38 citation statements)

References 34 publications

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“…80 Likewise, addition of glucose, hydrogen peroxide, and an enzyme can be used to produce gluconic acid in situ. 85 It is also possible to add other precursors that hydrolyze to give acids. 81 In all of this, reproducibility is really important; to our minds, there is little point in being able to form a gel if that gel does not have the same properties each time it is made.…”

Section: Process Of Assemblymentioning

confidence: 99%

Low-Molecular-Weight Gels: The State of the Art

Draper

Adams

2017

Chem

539

469

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Low-molecular-weight gels are currently a hugely important class of materials that are attracting significant interest. These gels are formed when small molecules self-assemble into one-dimensional structures that entangle and cross-link to form a network that is capable of immobilizing the solvent. Here, we critically discuss the current state of the art and highlight two key areas where we believe there is significant untapped potential. The first is the observation that the properties of the gels are highly process dependent, which means that it is possible to access materials with very different properties from a single gelator. Second, using multiple gelators offers the opportunity to prepare materials with a high degree of information content and with a wider range of properties. We aim to spark thought and discussion on these aspects. INTRODUCTIONLow-molecular-weight gels (LMWGs), or supramolecular gels, are a fascinating and useful class of material. The gels arise from the self-assembly of small molecules into long, anisotropic structures, most commonly fibers. [1][2][3][4][5] At a sufficiently high concentration, these fibers entangle or otherwise form cross-links, leading to the network that is able to immobilize the solvent through surface tension and capillary forces. 1,2 These gels differ from permanently covalently cross-linked polymer gels because the cross-linking can be reversed by the input of energy, for example, by heating. 6 LMWGs have been around for many years but are receiving considerable current interest. 4 They are also used in industrial products, 7 although this seems rarely discussed in the academic literature.In addition to the industrial applications, many recent advances and uses are being described. [8][9][10][11][12] The specific self-assembly leading to gel formation can be exploited. For example, the fiber formation is a result of molecular stacking, meaning that the self-assembly leads to aggregates that can be suitable for optoelectronic applications. 13,14 The ready reversibility of gelation can be exploited, for example, to release cells from gels on demand in a manner that does not lead to cell death. 15 Ready gel formation by a simple trigger can also be used to allow easy and efficient gel loading. [16][17][18] Unsurprisingly, therefore, there is significant interest in these materials ( Figure 1). This is a fascinating area and in many ways holds attention because of the difficulties in probing and understanding the gels. The gels arise from assembly across many length scales, and understanding all of these is difficult. At the molecular level, the molecules must interact in a manner that leads to the formation of suitable aggregates that can eventually entangle. Thus, one-dimensional growth must be favored. From this perspective, it is very frustrating that it is often extremely difficult to predict whether a molecule will form a gel or not; indeed, gelation has been described as an empirical science. 4 Structurally similar small molecules can exhibitThe Bigger Pict...

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Section: Process Of Assemblymentioning

confidence: 99%

Low-Molecular-Weight Gels: The State of the Art

Draper

Adams

2017

Chem

539

469

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“…Supramolecular hydrogels are formed by self‐assembly of small molecules (hydrogelators) through noncovalent interactions such as metal–ligand, π–π stacking, electrostatic interactions, and hydrogen bonding . Thanks to self‐assembly and noncovalent interactions of hydrogelators, supramolecular hydrogels are biocompatible, biodegradable, and have the capability to respond to external stimuli such as anions, cations (ionic strength), and pH . Moreover, due to the small molecular weights of hydrogelators (usually below 2000 Da), their clearance from the body is more effective than that of polymeric hydrogels, which possess higher molecular weights .…”

Section: Protein‐responsive Hydrogelsmentioning

confidence: 99%

Biomolecule‐Responsive Hydrogels in Medicine

Sharifzadeh

Hosseinkhani

2017

Adv Healthcare Materials

108

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Recent advances and applications of biomolecule-responsive hydrogels, namely, glucose-responsive hydrogels, protein-responsive hydrogels, and nucleic-acid-responsive hydrogels are highlighted. However, achieving the ultimate purpose of using biomolecule-responsive hydrogels in preclinical and clinical areas is still at the very early stage and calls for more novel designing concepts and advance ideas. On the way toward the real/clinical application of biomolecule-responsive hydrogels, plenty of factors should be extensively studied and examined under both in vitro and in vivo conditions. For example, biocompatibility, biointegration, and toxicity of biomolecule-responsive hydrogels should be carefully evaluated. From the living body's point of view, biocompatibility is seriously depended on the interactions at the tissue/polymer interface. These interactions are influenced by physical nature, chemical structure, surface properties, and degradation of the materials. In addition, the developments of advanced hydrogels with tunable biological and mechanical properties which cause no/low side effects are of great importance.

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“…Magnetic particles have many advantages, such as the environmental friendliness, [17] large surface area, [18,19] low-cost, [20,21] and easy isolation. [22] Hence, scientists are encouraged to explore a wide variety of applications, including separation of active components, [23] drug delivery, [24,25] nanobiosensors, [26] gene therapy, [27] diagnostics, [28] labeling/cell separation, [29] and hyperthermia. [30,31] Furthermore, the above-mentioned extraction process produces a mixture of large amount of active components.…”

Section: Introductionmentioning

confidence: 99%

Extraction of Rutin and Rhoifolin by Inorganic Borate Functionalized Magnetic Particles

Hui

Han

2016

Chin. J. Chem.

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We demonstrate a facile approach for smart time-saving extraction of active components of rutin and rhoifolin by a new kind of magnetic particles (MPs). The inorganic borate functionalized magnetic particles are quasi-spherical with an average diameter of 200-220 nm. The MPs were characterized by scanning electron microscopy and X-ray diffraction techniques. The inorganic boron content in MPs was confirmed by electron-dispersive X-ray spectroscopy. The extraction and release efficiency of MPs were investigated. The smart borate-decorated magnetic particles show a specific extraction towards the active components containing cis-1,2 diol moieties. Rutin and rhoifolin were extracted at 16.55 and 22.49 mg/g, respectively. The recycling test shows that MPs can be reused and maintain a significant efficiency for seven cycles. Hence, a novel structured and reusable magnetic nanomaterial for extracting rutin and rhoifolin was developed. This strategy of specific extraction will be an important method to obtain the active components with some structure features through designing various structured particles.

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Biological Glucose Metabolism Regulated Peptide Self‐Assembly as a Simple Visual Biosensor for Glucose Detection

Cited by 65 publications

References 34 publications

Low-Molecular-Weight Gels: The State of the Art

Low-Molecular-Weight Gels: The State of the Art

Biomolecule‐Responsive Hydrogels in Medicine

Extraction of Rutin and Rhoifolin by Inorganic Borate Functionalized Magnetic Particles

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