Biological Half-Life of Chlordiazepoxide and Its Metabolite, Demoxepam, in Man

Schwartz, Morton A.; Postma, Edward; Gaut, Zane N.

doi:10.1002/jps.2600601012

Cited by 40 publications

(11 citation statements)

References 6 publications

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“…In the present experiments the curves of recovery of function for reaction time and adaptive tracking respectively intersected the zero axes at 6 h and 7.5 h after ingestion. With chlordiazepoxide hydrochloride (10 mg) the initial effect on performance is limited, but it tends to persist, and this may be related to a half life which varies between 6 and at least 15.5 h (Schwartz, Postma & Gaut, 1971). With this drug the curve of recovery for reaction time intersected the zero axis at 7.5 h after ingestion.…”

Section: Discussionmentioning

confidence: 99%

Immediate effects on human performance of a 1,5‐genzodiazepine (clobazam) compared with the 1,4‐benzodiazepines, chlordiazepoxide hydrochloride and diazepam.

Borland¹,

Nicholson²

1975

Brit J Clinical Pharma

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1 The immediate effects on human performance of the 1,5-benzodiazepine, clobazam (20 mg), and the 1,4-benzodiazepines, chlordiazepoxide hydrochloride (20 mg) and diazepam (10 mg), were studied by adaptive tracking and measurement of reaction time. Each drug was ingested at 09.00 h and performance was measured at 09 h 30 min (0.5 h), 11 h 30 min (2.5 h), 14 h 30 min (5.5 h) and 18 h 30 min (9.5 h after ingestion). 2 With diazepam decrements in performance on adaptive tracking were observed at 0.5 h and 2.5 h and performance was enhanced at 9.5 h after ingestion. With clobazam performance at individual times did not differ significantly from control, but there was evidence of an improvement in performance during the day. There was no evidence of impaired performance on adaptive tracking after chlordiazepoxide hydrochloride. 3 Reaction time was slowed at 0.5 h and 2.5 h after diazepam and chlordiazepoxide hydrochloride. A decrease in reaction time was observed at 9.5 h after diazepam. No changes in reaction time were observed after clobazam. 4 The subjects as a group differentiated correctly between performance decrements on adaptive tracking after diazepam and the absence of performance decrements after clobazam and chlordiazepoxide hydrochloride. The persistence of the decrement in performance after diazepam was accurately assessed. 5 It is evident that the nature and persistence of impaired performance and the ability to appreciate impaired performance vary considerably between the benzodiazepines, and that the choice of a benzodiazepine should include careful consideration of performance sequelae.

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Section: Discussionmentioning

confidence: 99%

Immediate effects on human performance of a 1,5‐genzodiazepine (clobazam) compared with the 1,4‐benzodiazepines, chlordiazepoxide hydrochloride and diazepam.

Borland¹,

Nicholson²

1975

Brit J Clinical Pharma

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“…For instance, the metabolite demoxepam relates exclusively to the parent compound chlordiazepoxide [38]. In other cases, the categorization of metabolites is more complicated.…”

Section: Categorization Criteriamentioning

confidence: 99%

Prevalence of medicinal drugs in suspected impaired drivers and a comparison with the use in the general Dutch population

Bezemer

Smink

Maanen

et al. 2014

Forensic Science International

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“…In all of these single-dose studies (3,5,6), plasma I1 levels were less than 0.2 pg/ml. Differential spectrofluorometric methods (2,3) generally used for chlordiazepoxide bioavailability studies (5-9) had a limit of sensitivity of about 0.1-0.2 pglml for 1-111 using 2-ml specimens.…”

Section: Resultsmentioning

confidence: 79%

“…Schwartz et al (3) later increased the sensitivity to 0.1 pg/ml by using a spectrofluorometer containing a new xenon lamp. The reported sensitivity is about 0.2-0.3 pglml for each compound.…”

mentioning

confidence: 99%

Quantitative Determination of Chlordiazepoxide and Its Metabolites in Serum by Fluorescence TLC-Densitometry

Sun

1978

Journal of Pharmaceutical Sciences

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Biological Half-Life of Chlordiazepoxide and Its Metabolite, Demoxepam, in Man

Cited by 40 publications

References 6 publications

Immediate effects on human performance of a 1,5‐genzodiazepine (clobazam) compared with the 1,4‐benzodiazepines, chlordiazepoxide hydrochloride and diazepam.

Immediate effects on human performance of a 1,5‐genzodiazepine (clobazam) compared with the 1,4‐benzodiazepines, chlordiazepoxide hydrochloride and diazepam.

Prevalence of medicinal drugs in suspected impaired drivers and a comparison with the use in the general Dutch population

Quantitative Determination of Chlordiazepoxide and Its Metabolites in Serum by Fluorescence TLC-Densitometry

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