Biological Importance of Phytoconstitents Isolated from the Genus Randia & GC-MS Analysis of Petroleum-Ether Fruit Extract of Randia dumetorum

Abstract

Randia Genus (Indigo berry) belongs to family Rubiaceae, native to America, allocated in tropical regions. Most of the Species associated with this Genus used as ornamental, folk medicine to treat the disease of renal, malaria, cancer, dysentery, snake-bite etc. All plant parts are used by tribes for various ailment treatments. The phytochemicals generally associated with this genus are terpenoids, saponins, lignans, coumarin, iso-coumarin, flavonoids, tannins, essential oil and acid resin. This review highlights the phytochemicals and pharmacological activity reports. Phytochemical investigation of Randia dumetorum fruit extract using petroleum ether solvent, reveals the presence of 2,4-di-tert-butylphenol, octadecadienoic acid, 23(Phenylsulfanyl) lanosta-8,24-dien-3-ol, hexadecenoic acid, gamma-sitosterol, 4-tert-butylcalix[4]arene, tetracontane, tetratetracontane and octacosanol etc. Compound 1-Octacosanol (A), 9-Octadecenoic acid (B) and gamma-Sitosterol (C) were isolated with the help of column chromatographic techniques and characterized by spectral studies i.e. 1H NMR, 13C NMR, IR and mass spectroscopy.