Biological Incorporation of Lyophilized Radiation Sterilized Bone Allograft and Mixed Bone Graft for the Management of Cysts and Cyst Like Lesions in Bone

Abstract

Cystic lesions include Simple bone cyst and Aneurysmal bone cyst, and among cyst like lesions studied Giant cell tumor, fibrous dysplasia and Non-ossifying fibroma. This prospective interventional study was conducted in the Department of orthopaedic surgery Bangubandhu Sheikh Mujib Mdical university (BSMMU) and Biomedical research division, Atomic energy centre Savar, Dhaka Bangladesh from January 2004 to December 2019. Out of 155 Cysts and cysts like lesions were operated, among which cystic lesions were 73 (47.10%), among cystic lesions SBC was 51 (69.86%), and ABC-22 (30.14%) and cyst like lesions were 82 (52.90%), among cyst like lesions GCT was 68 (82.92%), FD was 12 (14.63%) & NOF was 2 (2.43%). All cases were operated by thorough curettage and cavity filled with Lyophilized radiation sterilized bone allograft impregnated with autogenous bone marrow for children and mixed bone graft in adult. Clinical and radiological evaluation was done in all cases in which 61 (83.56%) out of 73 cystic lesions were healed and 12 (16.44%) lesions were recurred, on the other hand 58 (70.73%) out of 82 cyst like lesions were healed and 24 (29.27%) lesions were recurred. Out of 155 cysts and cyst like lesions 119 (76.78%) were healed / satisfactory and 36 (23.22%) were recurred. Follow up period were 9 month to 15 years. P value is <.001. Main aims to evaluate the complete healing of cystic and cyst like lesions of bone with in corporation of allograft. Bone marrow impregnated Lyophilized radiation sterilized bone allograft and mixed bone graft is useful graft material for healing of the lesional area and restoring structural integrity as well as function for management of cysts and cyst like lesions in bone.