Biological Indicators of Oxidative Stress [Malondialdehyde, Catalase, Glutathione Peroxidase, and Superoxide Dismutase] and Their Application in Nutrition

Martins, Maria do Carmo de Carvalho e; Martins, Marcos A. P.; Oliveira, Amanda Suellenn da Silva Santos; Silva, Liriane Andressa Alves da; Primo, Maísa Guimarães Silva; Lira, Vanessa Brito de Carvalho

doi:10.1007/978-3-030-81304-8_49-1

Cited by 16 publications

(15 citation statements)

References 100 publications

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“…MDA is a reactive aldehyde formed as a byproduct of lipid peroxidation, which occurs when free radicals interact with polyunsaturated fatty acids in cell membranes. An increase in free radicals leads to overproduction of MDA [ 19 , 29 , 30 , 31 ]. It has been shown that MDA is highly reactive and mutagenic towards deoxyribonucleic acid [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, the determination of CAT activity is used as a useful and feasible biomarker for the evaluation of oxidation–reduction status. Moreover, alterations in CAT levels may impact the oxidative stress levels within cancer cells [ 31 , 38 , 39 ]. The glutathione system is one of the main antioxidant systems in cells and consists of glutathione, GSH-Px, and glutathione s-transferases.…”

Section: Discussionmentioning

confidence: 99%

“…Decreased levels of GPx-1 may result in the initiation of carcinogenesis, and in later stages of cancer, GSH-Px deficiency may even cause proliferative effects. However, adequate GPx-1 levels may block cell death through apoptosis, prevent deoxyribonucleic acid oxidation, help reduce the inflammatory process and thus contribute to increasing the chances of survival of transformed cells [ 31 , 40 ].…”

Section: Discussionmentioning

confidence: 99%

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Multiple Myeloma from the Perspective of Pro- and Anti-Oxidative Parameters: Potential for Diagnostic and/or Follow-Up Purposes?

Kul,

Ozturk Kurt

2024

JPM

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Background: Multiple myeloma is a hematological malignancy characterized by anemia, antibodies causing kidney damage, and damage to multiple organs, which come together to cause morbidity. Although oxidative stress is not a core pathological aspect of multiple myeloma, reactive oxygen species (ROS) and antioxidant balance have been shown to play a role in the disease process and are considered in its management. In the presented study, we aim to assess the reliability of specific oxidant and antioxidant variables as potential biomarkers for multiple myeloma and to determine which of these variables might exhibit higher sensitivity in predicting multiple myeloma. Methods: This case-control study was conducted between March 2023 and August 2023. A total of 30 multiple myeloma patients, newly diagnosed according to the multiple myeloma diagnostic criteria revised by the International Myeloma Study Group in 2014, and a total of 30 volunteers without multiple myeloma were included in this study. Serum glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and catalase (CAT), and malondialdehyde (MDA) and nitric oxide (NO) levels were measured with the first blood samples taken after inclusion. Results: The groups had similar age (p = 0.623) and sex distribution (p = 1.000). MDA (cut-off: >4.35, p < 0.001), GSH-Px (<59.8, p < 0.001), CAT (<67.2, p < 0.001), SOD (<21.2, p = 0.001), and NO (>38.5, p < 0.001) could significantly detect multiple myeloma. Multivariate logistic regression revealed that increased MDA (p = 0.003) and NO (p = 0.001) levels and decreased GSH-Px (p = 0.001), CAT (p = 0.001), and SOD levels were independently associated with multiple myeloma disease. Conclusions: The presence of increased antioxidant levels and decreased antioxidant levels in patients with multiple myeloma is the clearest indicator of increased oxidative stress. These parameters may help to identify potential therapeutic targets and develop strategies to control disease progression.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Multiple Myeloma from the Perspective of Pro- and Anti-Oxidative Parameters: Potential for Diagnostic and/or Follow-Up Purposes?

Kul,

Ozturk Kurt

2024

JPM

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“…The co-ordinated system of antioxidant enzymes breaks down ROS. Dismutase enzyme for superoxidation catalyzes the conversion of anion radicals to H 2 O 2 molecules, which are then processed further by catalase to give minor amounts of glutathione peroxidase [14]. Reactive lipid peroxides are detoxified using glutathione peroxidase and glutathione transferase [15].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and molecular docking of novel fluorescent alkoxy‐substituted iodobiphenyl analogues

Alahmdi

2023

Luminescence

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New fluorescent iodobiphenyl ethers bearing para‐alkyloxy functional groups of diverse alkyl tail lengths were synthesized. The synthesis process was simply accomplished via an alkali‐assisted reaction of aliphatic alcohols with hydroxyl‐substituted iodobiphenyls. The molecular structures of the prepared iodobiphenyl ethers were determined using Fourier transform infrared (FTIR) spectroscopy, elemental analysis, and nuclear magnetic resonance (NMR) spectroscopy. Both absorption and fluorescence spectra proved solvatochromic activity. The synthesized alkyloxy‐substituted iodobiphenyl analogues were tested for antioxidant effectiveness using 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) methodology. The antioxidant outcomes demonstrated that the longest hydrocarbon chain‐containing substituted iodobiphenyl analogues had a high efficacy with over an IC50 = 21.26 ± 0.36 μg/ml. Alkyloxy‐substituted iodobiphenyl analogues also underwent docking operations over the 5IKQ protein.

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“…Beyond the molecular level, zinc plays a pivotal role in boosting the body's immune system by supporting the development and function of immune cells, thereby enhancing its ability to fend of infections [3]. In addition, zinc contributes to the cell's antioxidant defense by being a component of superoxide dismutase, which neutralizes harmful reactive oxygen species and safeguards cellular structures from oxidative damage [4]. Zinc's infuence extends to hormonal regulation, neurotransmitter function, and cell signaling, infuencing critical processes ranging from hormone secretion to cognitive function.…”

Section: Introductionmentioning

confidence: 99%

Enhancing Zinc Uptake through Dual-Modification of Cicer arietinum Protein

Patil,

Bains,

Sridhar

et al. 2023

Journal of Food Biochemistry

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Zinc is crucial for physiological processes; however, deficiency persists globally. Binding zinc to plant proteins enhances absorption, minimizing toxicity risks and offering a potential solution for deficiency. Mineral binding efficiency of the unmodified protein is limited; hence, dual modification (succinylation and ultrasonication) is potentially used to achieve higher binding efficiency. Enhancing zinc uptake is crucial for cellular health due to its vital roles in various biological processes including enzymatic activity, DNA repair, immune function, antioxidant defense, hormone regulation, brain function, signaling, growth, gene expression, and reproduction. Therefore, this research aimed to develop a chickpea protein-zinc complex and to evaluate the influence of dual modification on their physiochemical, bioavailability, and cellular mineral uptake attributes. Succinylation exhibited significant improvements in the water-holding capacity by 28.73%, oil-holding capacity by 34.09%, and solubility by 5.46% of the chickpea protein-zinc complex as compared to the native complex. Mineral bioavailability increased by 8.32%, and there were notable increases in cellular uptake of zinc by 2.10%, retention by 5.80%, and transport by 3.96%, respectively. Furthermore, the dual modification approach resulted in a notable decrease in the particle size of the chickpea protein-zinc complex, with a substantial reduction of 73.25% and an increased zeta potential value of −21 mV compared to the succinylated complex. As well, dual modification concurrently led to a substantial decline of 48.04% in the sulfhydryl (SH) content, coupled with a marked increase of 21.92% in the surface hydrophobicity. In addition, zinc bioavailability, cellular uptake, retention, and transport were further enhanced by 1.89, 3.34, and 4.8% through dual modification. Our findings highlight that the dual modification of the chickpea protein-zinc complex shows a promising strategy for enhancing the techno-functional characteristics, bioavailability, and cellular uptake of zinc, which could be a better platform for developing vegan foods.

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Biological Indicators of Oxidative Stress [Malondialdehyde, Catalase, Glutathione Peroxidase, and Superoxide Dismutase] and Their Application in Nutrition

Cited by 16 publications

References 100 publications

Multiple Myeloma from the Perspective of Pro- and Anti-Oxidative Parameters: Potential for Diagnostic and/or Follow-Up Purposes?

Multiple Myeloma from the Perspective of Pro- and Anti-Oxidative Parameters: Potential for Diagnostic and/or Follow-Up Purposes?

Synthesis and molecular docking of novel fluorescent alkoxy‐substituted iodobiphenyl analogues

Enhancing Zinc Uptake through Dual-Modification of Cicer arietinum Protein

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