Biological Investigations and Spectroscopic Studies of New Moxifloxacin/Glycine‐Metal Complexes.

Elshafie, Hazem S.; Sakr, Shimaa H.; Sadeek, Sadeek A.; Camele, Ippolito

doi:10.1002/cbdv.201800633

Cited by 50 publications

(36 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The antimicrobial activity of the studied metal complexes could be due to the chemical structures of free ligand itself and the toxic nature of some metal ions [43,44]. On the other hand, the attachment between the parent ligand and the metal ions through the chelation process has reduced the polarity of some metal ions by sharing its positive charge with the donor groups, and possibly the π-electron delocalization within the whole chelate ring system [44].…”

Section: Mode Of Actionmentioning

confidence: 98%

“…On the other hand, the attachment between the parent ligand and the metal ions through the chelation process has reduced the polarity of some metal ions by sharing its positive charge with the donor groups, and possibly the π-electron delocalization within the whole chelate ring system [44]. Based on the above discussed mechanism, it is strongly hypothesized that the chelation process was able to increase the permeability of the microbial cell walls and the lipophilic nature of metal complexes, which lead to their penetration to the peptidoglycan layer of the plasma membrane, and later on lead to the complete cell death [43,45].…”

Section: Mode Of Actionmentioning

confidence: 99%

“…A bioassay based on SG and RE was carried out to evaluate the possible phytotoxic effect of the studied compounds on S. lycopersicum and L. sativum seeds [43,49]. Seeds were sterilized in 3% H 2 O 2 solution for 1 min and then were rinsed twice with deionized sterile water (dH 2 O).…”

Section: Phytotoxicity Assaymentioning

confidence: 99%

See 2 more Smart Citations

Biological and Spectroscopic Investigations of New Tenoxicam and 1.10-Phenthroline Metal Complexes

et al. 2020

Self Cite

View full text Add to dashboard Cite

In the present work, tenoxicam (H2Ten) reacted with Mn(II), Co(II), Ni(II), Cu(II) and Zn (II) ions in the presence of 1.10-phenthroline (Phen), forming new mixed ligand metal complexes. The properties of the formed complexes were depicted by elemental analyses, infrared, electronic spectra, proton nuclear magnetic resonance (1H NMR), mass spectrometry, thermogravimetric (TGA) and differential thermogravimetric (DTG) analysis, molar conductance and magnetic moment. IR spectra demonstrated that H2Ten acted as a neutral bidentate ligand, coordinated to the metal ions via the pyridine-N and carbonyl group of the amide moiety, and Phen through the nitrogen atoms. Kinetic thermodynamics parameters activation energy (E*), enthalpy of activation (ΔH*), entropy of activation (ΔS*), Gibbs, free energy (ΔG*) associated to the complexes have been evaluated. Antibacterial screening of the compounds was carried out in vitro against Clavibacter michiganensis, Xanthomonas campestris and Bacillus megaterium. Antifungal activity was performed in vitro against Monilinia fructicola, Penicillium digitatum and Colletotrichum acutatum. The possible phytotoxic effect of the studied compounds was also investigated on Solanum lycopersicum (tomatoes) and Lepidium sativum (garden cress) seeds. The anticancer activity was screened against cell cultures of HCT-116 (human colorectal carcinoma), HepG2 (human hepatocellular carcinoma) and MCF-7 (human breast adenocarcinoma).

show abstract

Section: Mode Of Actionmentioning

confidence: 98%

Section: Mode Of Actionmentioning

confidence: 99%

See 1 more Smart Citation

Biological and Spectroscopic Investigations of New Tenoxicam and 1.10-Phenthroline Metal Complexes

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…Scavenging of 2,2-diphenyl-1-picryl-hydrazyl (DPPH) free radical was measured using the methods of Sharma and Bhat [53] and Elshafie et al [54], with modifications. Plant tissue was extracted like in the method for TPC estimation.…”

Section: Spectrophotometric Estimation Of Antioxidative Properties Ofmentioning

confidence: 99%

Elicitation-Based Method for Increasing the Production of Antioxidant and Bactericidal Phenolic Compounds in Dionaea muscipula J. Ellis Tissue

Makowski

Tokarz

et al. 2020

Molecules

View full text Add to dashboard Cite

The carnivorous plant Dionaea muscipula J. Ellis (Venus flytrap) is a widely known medical herb, capable of producing various phenolic compounds known for their strong antioxidant and antibacterial properties. In the pharmaceutical industry, Venus flytrap is grown in tissue cultures, as the natural population of D. muscipula is very limited. Here, we describe an improved method to increase the quantity and quality of phenolic compounds produced in D. muscipula. This is achieved by combining biotic elicitation (using Cronobacter sakazakii bacteria lysate) of D. muscipula cultured with rotary shaking (hydromechanical stress), which we describe here for the first time. The antibacterial activity and the antioxidant properties of the obtained compounds were studied on two antibiotic-resistant human pathogenic bacteria. The proposed plant culture conditions resulted in an increase in fresh weight, as well as a higher total phenolic content, in comparison to traditional tissue cultures on agar-solidified medium. With the use of high-performance liquid chromatography, we demonstrated that the described elicitation strategy leads to an increased synthesis of myricetin, caffeic acid, ellagic acid and plumbagin in D. muscipula tissue. We also found that a higher level of antioxidant activity, exhibited by the plant extract, corresponded with its higher phenylpropanoid content. The bactericidal activity of the extract against Staphylococcus aureus was dependent on the duration of plant culture under described elicitation conditions, whereas neither elicitation condition (duration or elicitor concentration) seemed relevant for the bactericidal activity of the extract towards Escherichia coli. This suggest that Gram-negative bacteria are less sensitive to compounds derived from Venus flytrap tissue.

show abstract

“…The ability of quinolones to form metal complexes has been explored in various ways. Numerous studies revealed a superior antimicrobial activity of the metal complexes compared to the free ligands, or even new biological activities (antifungal, antiparasitic or anticancer) [22][23][24][25][26][27]. Moreover, the quinolone-metal complexes are valuable in the battle against bacterial resistance, since they present higher lipophilicity due to the chelation effect [28] and offer a different mechanism of action, including their capacity to bind DNA.…”

Section: Figurementioning

confidence: 99%

Quinolone Complexes with Lanthanide Ions: An Insight into their Analytical Applications and Biological Activity

2020

View full text Add to dashboard Cite

Quinolones comprise a series of synthetic bactericidal agents with a broad spectrum of activity and good bioavailability. An important feature of these molecules is their capacity to bind metal ions in complexes with relevant biological and analytical applications. Interestingly, lanthanide ions possess extremely attractive properties that result from the behavior of the internal 4f electrons, behavior which is not lost upon ionization, nor after coordination. Subsequently, a more detailed discussion about metal complexes of quinolones with lanthanide ions in terms of chemical and biological properties is made. These complexes present a series of characteristics, such as narrow and highly structured emission bands; large gaps between absorption and emission wavelengths (Stokes shifts); and long excited-state lifetimes, which render them suitable for highly sensitive and selective analytical methods of quantitation. Moreover, quinolones have been widely prescribed in both human and animal treatments, which has led to an increase in their impact on the environment, and therefore to a growing interest in the development of new methods for their quantitative determination. Therefore, analytical applications for the quantitative determination of quinolones, lanthanide and miscellaneous ions and nucleic acids, along with other applications, are reviewed here.

show abstract

Biological Investigations and Spectroscopic Studies of New Moxifloxacin/Glycine‐Metal Complexes.

Cited by 50 publications

References 53 publications

Biological and Spectroscopic Investigations of New Tenoxicam and 1.10-Phenthroline Metal Complexes

Biological and Spectroscopic Investigations of New Tenoxicam and 1.10-Phenthroline Metal Complexes

Elicitation-Based Method for Increasing the Production of Antioxidant and Bactericidal Phenolic Compounds in Dionaea muscipula J. Ellis Tissue

Quinolone Complexes with Lanthanide Ions: An Insight into their Analytical Applications and Biological Activity

Contact Info

Product

Resources

About