Biological landscape and nanostructural view in development and reversal of oxaliplatin resistance in colorectal cancer

Hashemi, Mehrdad; Esbati, Nastaran; Rashidi, Mohsen; Gholami, Sadaf; Raesi, Rasoul; Bidoki, Seyed Shahabadin; Goharrizi, Mohammad Ali Sheikh Beig; Motlagh, Yasamin Sadat Mousavi; Khorrami, Ramin; Tavakolpournegari, Alireza; Nabavi, Noushin; Zou, Rongjun; Mohammadnahal, Leila; Entezari, Maliheh; Taheriazam, Afshin; Hushmandi, Kiavash

doi:10.1016/j.tranon.2023.101846

Cited by 4 publications

References 256 publications

(210 reference statements)

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Advancements in melanoma immunotherapy: the emergence of Extracellular Vesicle Vaccines

He,

Li,

Zeng

et al. 2024

Cell Death Discov.

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Malignant melanoma represents a particularly aggressive type of skin cancer, originating from the pathological transformation of melanocytes. While conventional interventions such as surgical resection, chemotherapy, and radiation therapy are available, their non-specificity and collateral damage to normal cells has shifted the focus towards immunotherapy as a notable approach. Extracellular vesicles (EVs) are naturally occurring transporters, and are capable of delivering tumor-specific antigens and directly engaging in the immune response. Multiple types of EVs have emerged as promising platforms for melanoma vaccination. The effectiveness of EV-based melanoma vaccines manifests their ability to potentiate the immune response, particularly by activating dendritic cells (DCs) and CD8+ T lymphocytes, through engineering a synergy of antigen presentation and targeted delivery. Here, this review mainly focuses on the construction strategies for EV vaccines from various sources, their effects, and immunological mechanisms in treating melanoma, as well as the shortcomings and future perspectives in this field. These findings will provide novel insights into the innovative exploitation of EV-based vaccines for melanoma immune therapy.

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Advancements in melanoma immunotherapy: the emergence of Extracellular Vesicle Vaccines

He,

Li,

Zeng

et al. 2024

Cell Death Discov.

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Drug resistance mechanisms and treatment strategies mediated by Ubiquitin-Specific Proteases (USPs) in cancers: new directions and therapeutic options

Gao,

Xi,

Dai

et al. 2024

Mol Cancer

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Drug resistance represents a significant obstacle in cancer treatment, underscoring the need for the discovery of novel therapeutic targets. Ubiquitin-specific proteases (USPs), a subclass of deubiquitinating enzymes, play a pivotal role in protein deubiquitination. As scientific research advances, USPs have been recognized as key regulators of drug resistance across a spectrum of treatment modalities, including chemotherapy, targeted therapy, immunotherapy, and radiotherapy. This comprehensive review examines the complex relationship between USPs and drug resistance mechanisms, focusing on specific treatment strategies and highlighting the influence of USPs on DNA damage repair, apoptosis, characteristics of cancer stem cells, immune evasion, and other crucial biological functions. Additionally, the review highlights the potential clinical significance of USP inhibitors as a means to counter drug resistance in cancer treatment. By inhibiting particular USP, cancer cells can become more susceptible to a variety of anti-cancer drugs. The integration of USP inhibitors with current anti-cancer therapies offers a promising strategy to circumvent drug resistance. Therefore, this review emphasizes the importance of USPs as viable therapeutic targets and offers insight into fruitful directions for future research and drug development. Targeting USPs presents an effective method to combat drug resistance across various cancer types, leading to enhanced treatment strategies and better patient outcomes.

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Assessment of Anticancer Properties of Thai Plants

Yingngam

2024

Advances in Medical Diagnosis, Treatment, and Care

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Cancer, a critical health concern, necessitates safer, more effective treatments. This chapter explores the anticancer potential of traditional Thai plants, which, despite being underresearched, show significant promise. It focuses on bioactive compounds and their efficacy against various cancer types. The chapter categorizes these plants based on their active components and reviews both laboratory and animal studies to understand the underlying mechanisms involved in inhibiting cell growth, inducing cell death, and preventing tumor blood vessel formation. Clinical trials supporting these findings are also highlighted. Given their potential to improve or innovate cancer treatments, Thai plants present encouraging prospects. However, further research is essential to confirm the safety and efficacy of these approaches. These studies suggest that Thai plants could lead to the development of innovative anticancer drugs, signaling potential significant advancements in cancer therapy.

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Biological landscape and nanostructural view in development and reversal of oxaliplatin resistance in colorectal cancer

Cited by 4 publications

References 256 publications

Advancements in melanoma immunotherapy: the emergence of Extracellular Vesicle Vaccines

Advancements in melanoma immunotherapy: the emergence of Extracellular Vesicle Vaccines

Drug resistance mechanisms and treatment strategies mediated by Ubiquitin-Specific Proteases (USPs) in cancers: new directions and therapeutic options

Assessment of Anticancer Properties of Thai Plants

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