Biological links in periodontitis and rheumatoid arthritis: Discovery via text‐mining PubMed abstracts

Acharya, Aneesha; Li, Simin; Liu, Xiangqiong; Pelekos, George; Ziebolz, Dirk; Mattheos, Nikos

doi:10.1111/jre.12632

Cited by 5 publications

(5 citation statements)

References 92 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For the purpose of data extraction, the metadata and abstract of each publication returned from our search were collected in a single corpus and subjected to text-mining using the R packages RISmed ( 17 ) and Pubmed.mineR ( 18 ). The publications returned were analyzed in R to identify the cancer types/sites associated with each publication, as described by Acharya et al ( 19 ). Furthermore, the R package “PubmedmineR” was used for obtaining the names and frequency of occurrence of genes denoted in “Human Genome Nomenclature Committee” (HGNC) symbols ( 20 ).…”

Section: Methodsmentioning

confidence: 99%

A Review of Cancer Genetics and Genomics Studies in Africa

Rotimi

Salhia

2021

Front. Oncol.

View full text Add to dashboard Cite

Cancer is the second leading cause of death globally and is projected to overtake infectious disease as the leading cause of mortality in Africa within the next two decades. Cancer is a group of genomic diseases that presents with intra- and inter-population unique phenotypes, with Black populations having the burden of morbidity and mortality for most types. At large, the prevention and treatment of cancers have been propelled by the understanding of the genetic make-up of the disease of mostly non-African populations. By the same token, there is a wide knowledge gap in understanding the underlying genetic causes of, and genomic alterations associated with, cancer among black Africans. Accordingly, we performed a review of the literature to survey existing studies on cancer genetics/genomics and curated findings pertaining to publications across multiple cancer types conducted on African populations. We used PubMed MeSH terms to retrieve the relevant publications from 1990 to December 2019. The metadata of these publications were extracted using R text mining packages: RISmed and Pubmed.mineR. The data showed that only 0.329% of cancer publications globally were on Africa, and only 0.016% were on cancer genetics/genomics from Africa. Although the most prevalent cancers in Africa are cancers of the breast, cervix, uterus, and prostate, publications representing breast, colorectal, liver, and blood cancers were the most frequent in our review. The most frequently reported cancer genes were BRCA1, BRCA2, and TP53. Next, the genes reported in the reviewed publications’ abstracts were extracted and annotated into three gene ontology classes. Genes in the cellular component class were mostly associated with cell part and organelle part, while those in biological process and molecular function classes were mainly associated with cell process, biological regulation, and binding, and catalytic activity, respectively. Overall, this review highlights the paucity of research on cancer genomics on African populations, identified gaps, and discussed the need for concerted efforts to encourage more research on cancer genomics in Africa.

show abstract

Section: Methodsmentioning

confidence: 99%

A Review of Cancer Genetics and Genomics Studies in Africa

Rotimi

Salhia

2021

Front. Oncol.

View full text Add to dashboard Cite

show abstract

“…RA is a systemic autoimmune disease characterized by chronic inflammation of the joints, with subsequent cartilage and bone destruction involving massive infiltration of neutrophils mediated by cytokines such as TNF‐α and IL‐17. RA and periodontitis share similar clinical and pathologic features 62 . The prevalence of RA is much higher in patients with periodontitis than in those without periodontitis, and the severity of arthritis and periodontitis was shown to be positively correlated 63 …”

Section: Roles Of Bregs and Tregs In Systemic Diseases Associated Wit...mentioning

confidence: 99%

Phenotypes, roles, and modulation of regulatory lymphocytes in periodontitis and its associated systemic diseases

Zou

Zhou

Huang

et al. 2021

Journal of Leukocyte Biology

View full text Add to dashboard Cite

Periodontitis is a common chronic inflammatory disease that can result in tooth loss and poses a risk to systemic health. Lymphocytes play important roles in periodontitis through multiple mechanisms. Regulatory lymphocytes including regulatory B cells (Bregs) and T cells (Tregs) are the main immunosuppressive cells that maintain immune homeostasis, and are critical to our understanding of the pathogenesis of periodontitis and the development of effective treatments. In this review, we discuss the phenotypes, roles, and modulating strategies of regulatory lymphocytes including Bregs and Tregs in periodontitis and frequently cooccurring inflammatory diseases such as rheumatoid arthritis, Alzheimer disease, diabetes mellitus, and stroke. The current evidence suggests that restoring immune balance through therapeutic targeting of regulatory lymphocytes is a promising strategy for the treatment of periodontitis and other systemic inflammatory diseases.

show abstract

“…Conversely, a mouth with chronic infections, in my opinion, cannot/should not be considered healthy even if it is able to perform its function adequately. This is because chronic bacterial infections of the mouth are very well reported to correlate with numerous diseases, including rheumatoid arthritis, Alzheimer's disease, type 2 diabetes and cardiovascular diseases (Acharya et al 2019;Kubota et al 2014;Sochocka et al 2017;Sfyocras et al 2012;Söder & Yakob 2005). Furthermore, infections of the mouth have been reported to correlate with a reduction of lifespan in the elderly, possibly by aggravating other pathological conditions in the body (Söder et al 2007).…”

Section: Functional Aspects Of the Healthy Mouthmentioning

confidence: 99%

Healthy Mouth: An Odontological Perspective

Hjorth

2020

Healthy Ageing and Longevity

View full text Add to dashboard Cite

The face and the mouth are often considered to be the windows to our general health. Screening and monitoring of young children for healthy growth and development of the jaws and teeth is becoming a standard practice in more and more countries with a national health system/strategy. Such screenings are based on certain formal and informal notions of what a healthy mouth is. Making the ageing population more aware of their mouth and teeth status, and how oral health is connected to a healthy life is being realized increasingly. This article provides a brief overview of what characteristics are used while screening and evaluating the growth and development of a healthy mouth. The article describes the structural aspects of the healthy bony skeleton, temporomandibular joints, masticatory muscles, lips, palate, dental arches, occlusion, teeth, gingiva, periodontal ligament, oral mucosa, tongue, saliva and microbiome. This is followed by discussing the functional aspects of a healthy mouth, and finally commenting on the relation between a healthy mouth and a healthy body.

show abstract

Biological links in periodontitis and rheumatoid arthritis: Discovery via text‐mining PubMed abstracts

Cited by 5 publications

References 92 publications

A Review of Cancer Genetics and Genomics Studies in Africa

A Review of Cancer Genetics and Genomics Studies in Africa

Phenotypes, roles, and modulation of regulatory lymphocytes in periodontitis and its associated systemic diseases

Healthy Mouth: An Odontological Perspective

Contact Info

Product

Resources

About