Biological markers and ovarian carcinomas: Galactosyltransferase, CA 125, isoenzymes of amylase and alkaline phosphatase

Sichel, François; Salaün, Véronique; Bara, Edith; Gauduchon, Pascal; Malas, J.P.; Goussard, J; Talaër, Jean-Yves Le

doi:10.1016/0009-8981(94)90138-4

Cited by 8 publications

(7 citation statements)

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“…Elevated levels of numerous tumour‐associated antigens are associated with prognosis in patients with epithelial ovarian carcinoma. In addition to those analytes described in the present study, comparable findings have been reported for serum concentrations of cross‐linked carboxyterminal telopeptide of type 1 collagen 24 , interleukin 6 25 , galactosyltransferase 26 , tumour‐associated trypsin inhibitor 27 , tetranectin 28,29 , sialyl Tn 30 , low levels of serum albumin 3 and expression of epidermal growth factor 31 . Though serum concentrations of tumour‐associated antigens are associated with disease stage 5,32 , this and other studies suggest that the prognostic significance is independent of tumour progression 3,5 .…”

Section: Discussionsupporting

confidence: 89%

“…The value of PLAP as a tumour marker is consistent with earlier studies by ourselves and others 5,20,40–45 . However, some authors report that PLAP is not an efficient marker of disease progression and survival 26,46,47 . Some of these groups have used assays that measure the intrinsic catalytic activity of PLAP which is often defective when produced by tumours 40,48 .…”

Section: Discussionmentioning

confidence: 99%

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Serum concentrations of cancer antigen 125, placental alkaline phosphatase, cancer‐associated serum antigen and free beta human chorionic gonadotrophin as prognostic markers for epithelial ovarian cancer

Ind

Iles

Shepherd

et al. 1997

BJOG

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Objective To investigate the prognostic significance of elevated levels of cancer antigen 125 (CA125), placental alkaline phosphatase (PLAP), free p human chorionic gonadotrophin (hCG) and cancerassociated serum antigen (CASA) in women with primary epithelial ovarian carcinoma.Design A two year follow up study of survival.Setting A tertiary care gynaecological oncology unit.Participants One hundred and eleven women with histologically confirmed epithelial ovarian cancer. Main outcome measures Survival over a two year period.Results Stage corrected log-rank x2 tests demonstrated a significant effect on survival for all four tumour markers (CAI25 P = 0.0142; PLAP P < 0.0001; CASA P = 0.0098; hCG P = 0.0002). This was confirmed when each variable was fitted together with disease stage in Cox proportional hazard models. When fitted as multiple variables in a Cox proportional hazard model, the addition of free phCG and CASA to disease stage, PLAP concentrations and CAI25 levels did not demonstrate M e r prognostic value.Conclusions Levels of all four markers correlate with survival in patients with epithelial ovarian cancer.The combination of PLAP and CA125 concentrations together with disease stage may be used to predict survival but the addition of hCG and CASA levels do not give additional prognostic information. INTRODUCTIONMeasurement of circulating tumour markers in cases of epithelial ovarian cancer has been advocated for monitoring disease progression'. More recently their value in predicting prognosis has been studied. In particular, serum concentrations of CA125 and placental alkaline phosphatase (PLAP) have been shown to have an inverse correlation with To date, over 40 monoclonal antibodies against ovarian tumour-associated antigens have been reporteds. It is therefore important to know if serum concentrations of other tumour markers may predict prognosis. Furthermore, it is as yet unclear if the use of multiple markers gives additional prognostic infomation. Cancer-associated serum antigen (CASA) has been reported to have a high sensitivity9. Products of human chorionic gonadotrophin (hCG) have a prognostic Correspondence: Mr T. Ind, Department of Obstetrics and Gynaecology, Watford Hospital, Vicarage Road, Watford WD 1 8HB, UK. association with many tumours of the female reproductive tract'0.''. In this study we examined the prognostic value of PLAP, CA125, free P-hCG and CASA in women presenting with primary ovarian cancer. METHODSThe study included 111 consecutive women with histologically confirmed epithelial ovarian cancer who had serum collected before initial surgery between 199'1 and 1994. Serum was stored at -20°C. Specimens were available for PLAP measurements in all cases and in 99, 99 and 73 cases for CA125, CASA and free P-hCG respectively. This was due to inadequate sample volumes for the latter three analytes.The characteristics of the 111 women are summarised in Table 1 PLAPSerum concentrations of PLAP were measured in duplicate by an in-house immunoradiometric assay, as previously de...

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Serum concentrations of cancer antigen 125, placental alkaline phosphatase, cancer‐associated serum antigen and free beta human chorionic gonadotrophin as prognostic markers for epithelial ovarian cancer

Ind

Iles

Shepherd

et al. 1997

BJOG

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“…Amylase proteins are overexpressed in a variety of cancers and have been studied as serum markers for ovarian cancer (48). Amylase 1 has been found in the salivary gland and in lung cancers (49).…”

Section: Discussionmentioning

confidence: 99%

Patterns of Gene Expression in Different Histotypes of Epithelial Ovarian Cancer Correlate with Those in Normal Fallopian Tube, Endometrium, and Colon

Marquez

Baggerly

Patterson

et al. 2005

Clinical Cancer Research

282

203

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Purpose: Epithelial ovarian cancers are thought to arise from flattened epithelial cells that cover the ovarian surface or that line inclusion cysts. During malignant transformation, different histotypes arise that resemble epithelial cells from normal fallopian tube, endometrium, and intestine. This study compares gene expression in serous, endometrioid, clear cell, and mucinous ovarian cancers with that in the normal tissues that they resemble. Experimental Design: Expression of 63,000 probe sets was measured in 50 ovarian cancers, in 5 pools of normal ovarian epithelial brushings, and in mucosal scrapings from 4 normal fallopian tube, 5 endometrium, and 4 colon specimens. Using rank-sum analysis, genes whose expressions best differentiated the ovarian cancer histotypes and normal ovarian epithelium were used to determine whether a correlation based on gene expression existed between ovarian cancer histotypes and the normal tissues they resemble. Results: When compared with normal ovarian epithelial brushings, alterations in serous tumors correlated with those in normal fallopian tube (P = 0.0042) but not in other normal tissues. Similarly, mucinous cancers correlated with those in normal colonic mucosa (P = 0.0003), and both endometrioid and clear cell histotypes correlated with changes in normal endometrium (P = 0.0172 and 0.0002, respectively). Mucinous cancers displayed the greatest number of alterations in gene expression when compared with normal ovarian epithelial cells. Conclusion: Studies at a molecular level show distinct expression profiles of different histologies of ovarian cancer and support the long-held belief that histotypes of ovarian cancers come to resemble normal fallopian tube, endometrial, and colonic epithelium. Several potential molecular markers for mucinous ovarian cancers have been identified. Most investigators believe that epithelial ovarian cancersdevelop from a single layer of cells that cover the ovary or that line inclusion cysts immediately beneath the ovarian surface (1). Despite their origin from flattened cells without distinctive features, ovarian cancers differentiate during malignant transformation into four major histotypes: serous, endometrioid, clear cell, and mucinous. Pathologists have pointed to a morphologic resemblance between these histotypes and the differentiation of normal mucosal cells in the gynecologic and intestinal tracts. Thus, serous carcinomas are thought to resemble fallopian tube epithelium, endometrioid carcinomas to normal endometrium, clear cell carcinomas to vaginal rests, and mucinous carcinomas to normal endocervical glands or intestinal mucosa. Molecular alterations that contribute to these morphologic changes have not been adequately studied.Previous reports have shown that tumors of different histotypes can have distinct characteristics with regard to epidemiology, genetic abnormalities, expression of tumor markers, and response to chemotherapy (1 -3). Parity, breastfeeding, and oral contraceptive use have been associated with dec...

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“…These include several markers identified through biochemical assays, multifunction proteins, and general measures of the degree of gycosylation. Enzymatic tests of potential value for ovarian cancer include alpha-fucosidase, galacotsyltransferase, and LDH [1,8,54,81,86,96]. RNAase A is a biomarker initially assessed for other cancers but found to be elevated in the urine of ovarian cancer patients identified through mass spectrometric approaches [107].…”

Section: Other Markersmentioning

confidence: 99%

Blood and Urine Markers for Ovarian Cancer: A Comprehensive Review

et al. 2004

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Biological markers and ovarian carcinomas: Galactosyltransferase, CA 125, isoenzymes of amylase and alkaline phosphatase

Cited by 8 publications

References 16 publications

Serum concentrations of cancer antigen 125, placental alkaline phosphatase, cancer‐associated serum antigen and free beta human chorionic gonadotrophin as prognostic markers for epithelial ovarian cancer

Serum concentrations of cancer antigen 125, placental alkaline phosphatase, cancer‐associated serum antigen and free beta human chorionic gonadotrophin as prognostic markers for epithelial ovarian cancer

Patterns of Gene Expression in Different Histotypes of Epithelial Ovarian Cancer Correlate with Those in Normal Fallopian Tube, Endometrium, and Colon

Blood and Urine Markers for Ovarian Cancer: A Comprehensive Review

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