Biological Markers in Obesity: Fundamental and Clinical Laboratory Aspects

Timofeev, Yu. S.; Dzhioeva, O. N.; Drapkina, O. M.

doi:10.15829/ropniz-t1-2024

2024

DOI: 10.15829/ropniz-t1-2024

|View full text |Cite

Biological Markers in Obesity: Fundamental and Clinical Laboratory Aspects

Yu. S. Timofeev,

O. N. Dzhioeva,

O. M. Drapkina

Abstract: АД -артериальное давление БСЖК -белок, связывающий жирные кислоты (FABP) БТШ -белок теплового шока (HSP -heat shock proteins) ЖК -жирные кислоты ИБС -ишемическая болезнь сердца ИЛ -интерлейкин (например ИЛ-6, ИЛ-10 и т.д.) ИМ -инфаркт миокарда ИМТ -индекс массы тела ИФР -инсулиноподобный фактор роста ИФРСБ -белок, связывающий инсулиноподобный фактор роста ЛВП -липопротеиды высокой плотности ЛНП -липопротеиды низкой плотности ЛОНП -липопротеиды очень низкой плотности ММП -матриксная металлопротеиназа (MMP) НАЖБ… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Associations of circulating adipokines and coronary artery disease in young adults

Khudiakova,

Polonskaya,

Shcherbakova

et al. 2024

Cardiovasc Ther Prev

View full text Add to dashboard Cite

Aim. To evaluate the associations of abdominal obesity (AO), adipokines and premature coronary artery disease (CAD) in young people for a deeper understanding of the pathogenesis of atherosclerotic diseases.Material and methods. A total of 1457 people were examined, including 653 (44,8%) men. Mean age was 36,7±6,0 years. Premature CAD was detected in 46 people, while 4 following subgroups were formed (138 people in total): with CAD and AO; with CAD, without AO; control groups by age and sex: without CAD, with AO; without CAD, without AO.Results. Premature CAD in young people is associated with an increase in non-high-density lipoprotein cholesterol (non-HDL-C). Univariate analysis found that the probability of CAD increased by 1% with an increase in adiponectin level, and by 0,2% with an increase of 1 ng/ml in resistin level. Multivariate regression analysis, including sex, age, waist circumference, non-HD-C, adiponectin, and resistin, significant associations were obtained for non-HDL-C and adiponectin. With AO, the CAD probability increased by 0,6% with an increase in plasminogen activator inhibitor-1 level (PAI-1). However, when non-HDL-C was included in the model, significance for this biomarker was not achieved.Conclusion. In young people, CAD is associated with increased levels of non-HDL cholesterol, adiponectin, resistin and PAI-1. Independent associations with premature CAD were obtained only for adiponectin, which makes this marker promising for study in young people.

show abstract

Associations of circulating adipokines and coronary artery disease in young adults

Khudiakova,

Polonskaya,

Shcherbakova

et al. 2024

Cardiovasc Ther Prev

View full text Add to dashboard Cite

show abstract

Associations of levels of biochemical markers of chronic and acute inflammation, abdominal obesity and post-COVID syndrome in COVID-19 convalescents

Karaseva,

Afanaseva,

Garbuzova

et al. 2024

Cardiovasc Ther Prev

View full text Add to dashboard Cite

Aim. To study the associations of abdominal obesity (AO), levels of biochemical markers of chronic and acute inflammation, and post-COVID syndrome (PCS) in coronavirus disease 2019 (COVID-19) convalescents.Material and methods. The cross-sectional observational study included 166 people aged 18-84 (44,6% men) who were COVID-19 convalescents. In all patients, medical history and anthropometric data were collected. AO was defined as waist circumference >80 cm in women and >94 cm in men. In the blood serum, the concentrations of following biochemical markers of chronic and acute inflammation were determined by the enzyme immunoassay method: interferon alpha, interleukins (IL) 1 beta (IL-1β), IL-6, IL-8, monocyte chemoattractant protein-1 (MCP-1), insulin, C-peptide, high-sensitivity C-reactive protein (hsCRP).Results. COVID-19 convalescents with PCS and AO had significantly higher levels of IL-6 (3,13 [2,26;4,98] and 1,74 [1,10;3,04] pg/ml, p<0,0001, respectively) and hsCRP (3,83 [2,42;10,16] and 2,34 [0,70;5,79] mg/l, p=0,028, respectively) than without AO. Insulin and C-peptide demonstrated significant differences in COVID-19 convalescents with AO regardless of PCS. Multivariate logistic regression analysis showed that the odds of having AO in COVID-19 convalescents with PCS increased by 1,6 times with an increase in blood IL-6 by 1 pg/ml (odds ratio (OR) 1,581, 95% confidence interval (CI): 1,001-2,416; p=0,047) and by 1,2 times with an increase in blood insulin by 1 pg/ml (OR 1,168, 95% CI: 1,015-1,343; p=0,030). AO in men with PCS is associated with the concentration of IL-6 (OR 1,943, 95% CI: 1,018-3,709; p=0,044) and IL-1β (OR 0,591, 95% CI: 0,362-0,967; p=0,036). PCS in women with AO and cardiovascular diseases is associated with the level of MCP-1 (OR 0,991, 95% CI: 0,983-0,999; p=0,035).Conclusion. In COVID-19 convalescents with PCS, the AO probability is associated with an increase in blood IL-6 and insulin. In men, the AO probability is associated with an increase in IL-6 and a decrease in IL-1β. In women with AO and a history of cardiovascular diseases, PCS is associated with the level of MCP-1 in the blood.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Biological Markers in Obesity: Fundamental and Clinical Laboratory Aspects

Cited by 2 publications

References 35 publications

Associations of circulating adipokines and coronary artery disease in young adults

Associations of circulating adipokines and coronary artery disease in young adults

Associations of levels of biochemical markers of chronic and acute inflammation, abdominal obesity and post-COVID syndrome in COVID-19 convalescents

Contact Info

Product

Resources

About