Biological Markers in Transurethral Biopsies From Bladder-Cancer - Preliminary-Results

Benini, Elvira; Costa, André Leonardo de Castro; Pizzocaro, Giorgio; Campo, B.; Milani, Angelo; Torelli, Tullio; Veneroni, Silvia; Ordesi, G.; Pilotti, Silvana; Silvestrini, R

doi:10.3892/ijo.3.5.817

Cited by 3 publications

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“…For Ta and T1 tumors as well as for muscle-invasive TCC, almost identical results were obtained by Lipponen and in the present study. Another analysis of p53 overexpression has been reported by Bennini et al [2]. Although the results these authors obtained in Ta and T1 tumors are similar to the observations made by us in the present study and by Lipponen, the large number of p53-positive tumors observed among the advanced tumors examined by Bennini et al contrasts with reports made by several other authors [12,26].…”

Section: Discussioncontrasting

confidence: 57%

“…Several investigators have reported on the correlation of p53 accumulation or loss of heterozygosity with tumor stage or tumor grade [2,6,18,26]. Most of these investigations, however, were performed on a limited number of specimens and thus did not allow definite statements to be made.…”

Section: Discussionmentioning

confidence: 99%

“…The consideration of cytoplasmic staining in roughly one-third of the p53-positive specimens or the selection of very unfavorable cases (G3 cases, 44%) might account for these differences. No TIS or dysplasia was examined by either Lipponen [12] or Bennini et al [2].…”

Section: Discussionmentioning

confidence: 99%

“…In several investigations the frequency of p53 mutations has been found to correlate with tumor stage and tumor grade. In advanced high-grade tumors, up to 100% of the specimens were reported to show p53 accumulation, indicating the existence of a disabled p53 gene product [2]. More recently, p53 accumulation has been observed in a considerable number of superficially invasive bladder cancer [stage T1 according to the International Union Against Cancer (UICC) classification] specimens [12,22] indicating that even in early stages of bladder cancer, p53 may be altered.…”

Section: Summary Recent Investigations Have Demonstrated Al-mentioning

confidence: 99%

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P53 accumulation in precursor lesions and early stages of bladder cancer

et al. 1994

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Recent investigations have demonstrated alterations of the p53 tumor-suppressor gene in a considerable number of transitional-cell carcinoma (TCC) specimens. Thus far, these investigations have been restricted to either papillary TCC or invasive bladder cancer. To obtain further information on a possible involvement of p53 in bladder cancer development or tumor progression, investigations of precursor lesions and early stages of this disease are required. Immunohistochemical examination of 6 dysplasias and 24 carcinomas in situ (TIS) showed p53 accumulation, which is suggestive of p53 inactivation, in 2 (33%) and 9 (38%) of these specimens, respectively. This ratio was similar in 9 T1 lesions (33%) and in 14 cases of muscle-infiltrative disease (35%). In papillary tumors, p53 accumulation was observed exclusively in 3/10 moderately differentiated or high-grade lesions but not in 1 Ta G1 tumor. The expression of p53 accumulation was a consistent finding. The examination of tumor recurrences yielded either the presence or the absence of p53 overexpression in the primary and recurrent tumors of 7/8 patients. Similarly, in multifocal TCC, p53 accumulation was also either present or absent in 10/11 cases examined. These results suggest the existence of at least two different subgroups of TCC, with p53 accumulation being present in one of these groups. The observation of p53 accumulation in dysplasia and in TIS is a prerequisite for a possible involvement of p53 in bladder cancer carcinogenesis, although it does not prove this assumption.

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Section: Discussioncontrasting

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Summary Recent Investigations Have Demonstrated Al-mentioning

confidence: 99%

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P53 accumulation in precursor lesions and early stages of bladder cancer

et al. 1994

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“…Moreover, mechanisms other than gene alterations can induce P53 inactivation and, subsequently, protein accumulation ' Supported by grants from the Consiglio Nazionale delle Ricerche 8,9). Such findings and the recent availability of reagents such as the monoclonal antibody (MAb) PAbl801, which can detect the expression of mutant and wild-type PS3 proteins on paraffinembedded material, have allowed analysis of the biological and clinical roles of PS3 accumulation in substantial series of patients with different tumor types (10)(11)(12). In node-negative breast cancer, we demonstrated that P53 expression and S-phase cell fraction, as evalu-…”

Section: Introductionmentioning

confidence: 99%