Biological markers of families of patients with neurotic, stress-related and somatoform disorders

Abstract

Objective:Study biological markers of families with neurotic, stress-related and somatoform disorders for definition of probability of occurrence of mental disorders.Methods:131 families of patients with neurotic, stress-related and somatoform disorders. The clinical and genealogical analysis, immunofermantal analysis for definition of concentration of steroid and thyreoid hormones, estimate of processes of apoptosis at receptor and cell-like levels for patients and relatives of the first degree of relationship were carried out.Results:Spreading of mental pathology among relatives was about 6,85 %. There was the accumulation of repeated cases of similar disorders in these families and basic share of pathology was marked among the first degrees of relationships. Among relatives of patients the group of the raised risk of occurrence of mental disorders is revealed: 1,35 siblings; 1,04 children; 0,3 grandsons; 0,85 spouses corresponds to 1 patient. The statistically significant increased levels of cortizol, triiodthyronin and thyroxine (p<0,05) and the lowered maintenance of dehydroepiandrosteronum (p<0,05) is characteristic for patients in comparison with control. We have observed statistically significant increase of expression of a receptor CD95 in patients in comparison with control (p<0,05). For patients is characteristic the statistically significant increase of levels of spontaneous apoptosis of neutrophils (p<0,05) and lymphocytes. For their relatives is characteristic the tendency to an amplification of this process.Conclusions:Neurotic disorders are accompanied by features of biological processes, the knowledge of these features will allow rendering assistance with great efficiency.The investigation supported by project of RHSF №06-06-00691а.

Клінічні Прояви Ревматоїдного Артриту У Хворих Із Різними Генотипами Т102с Поліморфізму Гена Серотонінових Рецепторів 5-Нтr2а Залежно Від Статі

“…Генетичні варіанти поліморфних локусів генів, переважно тих, які беруть участь у метаболізмі нейромедіаторів, асоційовані з психічними розладами, а також пов'язані з їх фенотиповими ознаками -клінічними, психологічними тощо. Зокрема, з'ясовано, що поліморфізми в локусах T102C серотонінових рецепторів 5-HT2A пов'язують зі зміною емоційності, активності і розладами адаптації [1,3].…”