Biological mechanisms of aging predict age‐related disease co‐occurrence in patients

Abstract

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Linking interdisciplinary and multiscale approaches to improve healthspan—a new UK model for collaborative research networks in ageing biology and clinical translation

“…2 The same review 2 revealed a general lack of awareness and scrutiny of the potential offered for improving health in later life by ameliorating the ageing process itself. This unawareness is alarming when set against the backdrop of a quiet research revolution in biogerontology that has seen the identification of some key hallmarks of ageing, 3 evidence that these hallmarks and underlying mechanisms independently predict the emergence of age-related diseases in real patients, 4 and positive outcomes from preclinical and early-stage human clinical trials based on targeting ageing mechanisms. 5,6 Humanity stands on the threshold of being able to prevent multimorbidity and age-associated diseases by addressing the underlying biology of ageing; parallels with the era of antibiotics do not seem unduly hyperbolic.…”

“…This breadth allows the networks to identify interventions appropriate for different stages of the life course, with a shift in focus from disease-preventive approaches in early life and mid-life through to more intense clinical monitoring and interventions in older adults, including development and testing of new geroprotective and gerotherapeutic medicines, such as senolytic drugs 8,9. A multiscale, multisystem, and whole of life course approach to improve healthy life expectancy can be achieved by drawing these broad research disciplines together through a core focus on hallmarks that underlie the biology of ageing and drive age-related disease 4. AGENTS=Ageing and Nutrient Sensing network.…”

New hallmarks of ageing: a 2022 Copenhagen ageing meeting summary

“…Recently, these hallmarks have been criticized for being insufficient in serving as a causative paradigm of ageing [ 2 ]. Importantly though, they have recently been shown to map to age-related diseases [ 3 ]. To address this and to explore potential new hallmarks, a research symposium “New Hallmarks of Ageing” was held in Copenhagen (Denmark) on the 22nd of March 2022, focusing on novel findings and the recontextualization of the nine hallmarks of ageing.…”

Flaxseed oil ameliorates aging in d‐galactose induced rats via altering gut microbiota and mitigating oxidative damage

“…Aging is the degenerative changes in various tissues and organs of the organism, and is the result of the combined effects of many pathological and physiological processes. In a sense, aging is not a disease, but it makes the body more susceptible to age‐related diseases, 3 such as diabetes, 4 non‐alcoholic fatty liver, 5 atherosclerosis, 6 cardiovascular disease 7 and Alzheimer′s disease 4 . The free radical theory of aging believes that excessive reactive oxygen species (ROS) production will accelerate the aging process 8 .…”