Biological monitoring in the identification of the cancer of individuals exposed to chemical carcinogens.

Vainio, Harri; Sorsa, Marja; Rantanen, Jorma; Hemminki, Kari; Aitio, Antero

doi:10.5271/sjweh.2552

Cited by 17 publications

(3 citation statements)

References 15 publications

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“…The possibility of a potential mutagenic action of inhalation anaesthetics has been investigated with the Ames Salmonella assay system (Baden et al, 1977;Waskell, 1978;Baden and Simmon, 1980) and with the SCE test following exposure in vitro (White et al, 1979) and in vivo (Basler and Rohrborn, 1981;Niebuhr, 1981a, 1982a;Holmbergetal., 1982;Husumetal., 1984). Increased SCE in lymphocytes has been demonstrated as early as 75 min after the administration of a known SCE-inducing agent (Wulf et al, 1984) and an increased value of SCE following acute exposure is believed to persist for at least 4-16 weeks (Vainio et al, 1981). Therefore, it was reasonable to assume that the design of the present study would allow the detection of any change in SCE which might have been induced during the period of anaesthesia and surgery.…”

Section: Discussionmentioning

confidence: 89%

Sister Chromatid Exchanges in Cigarette Smokers: Effects of Halothane, Isoflurane or Subarachnoid Blockade

Husum

Valentin

Wulf³

et al. 1985

British Journal of Anaesthesia

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In a previous study of the potential mutagenic action of isoflurane using the sister chromatid exchange (SCE) test in lymphocytes of surgical patients, it appeared that SCE increased in a group of 11 cigarette smokers, there being no effect in patients who were non-smokers. In the present study, 63 cigarette smokers were examined by the SCE test before and after minor orthopaedic operations undertaken under halothane or isoflurane anaesthesia, or subarachnoid analgesia. No significant changes of SCE were observed, and the risk of having missed a "true" increase of more than 0.6 SCE per cell was less than 1%. It was concluded that, in cigarette smokers, SCE in lymphocytes were unchanged after both general anaesthesia and subarachnoid analgesia, and that there was no indication from the SCE test of a mutagenic action of halothane, or isofurane, in nitrous oxide.

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Section: Discussionmentioning

confidence: 89%

Sister Chromatid Exchanges in Cigarette Smokers: Effects of Halothane, Isoflurane or Subarachnoid Blockade

Husum

Valentin

Wulf³

et al. 1985

British Journal of Anaesthesia

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“…The biological monitoring of workers by measuring the mutagenicity of their urine by fluctuation tests (27) has been carried out in several types of occupations. Besides foundry workers, these occupations include nurses handling cytostatic drugs, rubber workers, and workers exposed to various industrial chemicals.…”

Section: Samplementioning

confidence: 99%

Community and occupational studies of lung cancer and polycyclic organic matter.

Rantanen¹

1983

Environ Health Perspect

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Finland is used as a model in attempts to study the possible association of the incidence of lung cancer and exposure of population to fossil fuel combustion products. Unfortunately because of great geographical variation of unknown origin in the incidence of lung cancer in Finland, detailed studies of the possible role of an individual exposure in the lung cancer risk are not possible. This background variation in the incidence is much greater than variation carried by any known etiological factor and does not clearly correlate with the degree of urbanization, industrialization, regional use of fossil fuels, number of motor vehicles or smoking habits. To get more precise information on the possible association of lung cancer incidence with exposure to fossil fuel combustion products, occupational studies serve as powerful tools. The definition of population is more reliable and the measurement of exposures can be done more precisely; moreover the management of confounding and modifying factors is more effective than in community studies. So far the studies carried out among the Finnish working population exposed to PAH compounds reveal an association between the lung cancer risk and exposure to PAHs.

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“…indicator might be alkylated amino acids (7). Urinary PCB indicators would include copro-and uroporphyrins (#).…”

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confidence: 99%

Exposure to chemical waste sites

1983

Environ. Sci. Technol.

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Scientific and legal experts are trying to resolve many problems in determining and monitoring health effects and in devising ways of compensating those who might have been injured by Exposure to chemical waste sites "Just about every chemical manufactured winds up in dumps, so exposure opportunities are tremendous," says Roy Albert of the New York University Medical Center. "Still, despite incidents such as Love Canal [Niagara Falls, N.Y.], where kids picked up things like raw chunks of lindane, high-level exposure is quite rare.

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Biological monitoring in the identification of the cancer of individuals exposed to chemical carcinogens.

Cited by 17 publications

References 15 publications

Sister Chromatid Exchanges in Cigarette Smokers: Effects of Halothane, Isoflurane or Subarachnoid Blockade

Sister Chromatid Exchanges in Cigarette Smokers: Effects of Halothane, Isoflurane or Subarachnoid Blockade

Community and occupational studies of lung cancer and polycyclic organic matter.

Exposure to chemical waste sites

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