Biological Monitoring of Arsenic exposure of Gallium Arsenide- and Inorganic Arsenic-Exposed Workers by Determination of Inorganic Arsenic and Its Metabolites in Urine and Hair

Yamauchi, Hiroshi; Takahashi, Keiko; Mashiko, Mari; Yamamura, Yukio

doi:10.1202/0002-8894(1989)050<0606:bmoaeo>2.0.co;2

Cited by 14 publications

(16 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The major concern with using hair or nails is the ability to account for the presence of exogenous arsenic, which may cause an overestimation of body burden (Agahain et al 1990;Vahter and Lind 1986;Yamauchi et al 1989). On the contrary, because of the potential presence of exogenous arsenic, hair and toenails have been considered useful markers for environmental contamination, as opposed to personal exposure.…”

mentioning

confidence: 99%

Hair and toenail arsenic concentrations of residents living in areas with high environmental arsenic concentrations.

Hinwood

Sim

Jolley

et al. 2003

Environ Health Perspect

125

View full text Add to dashboard Cite

Surface soil and groundwater in Australia have been found to contain high concentrations of arsenic. The relative importance of long-term human exposure to these sources has not been established. Several studies have investigated long-term exposure to environmental arsenic concentrations using hair and toenails as the measure of exposure. Few have compared the difference in these measures of environmental sources of exposure. In this study we aimed to investigate risk factors for elevated hair and toenail arsenic concentrations in populations exposed to a range of environmental arsenic concentrations in both drinking water and soil as well as in a control population with low arsenic concentrations in both drinking water and soil. In this study, we recruited 153 participants from areas with elevated arsenic concentrations in drinking water and residential soil, as well as a control population with no anticipated arsenic exposures. The median drinking water arsenic concentrations in the exposed population were 43.8 micro g/L (range, 16.0-73 micro g/L) and median soil arsenic concentrations were 92.0 mg/kg (range, 9.1-9,900 mg/kg). In the control group, the median drinking water arsenic concentration was below the limit of detection, and the median soil arsenic concentration was 3.3 mg/kg. Participants were categorized based on household drinking water and residential soil arsenic concentrations. The geometric mean hair arsenic concentrations were 5.52 mg/kg for the drinking water exposure group and 3.31 mg/kg for the soil exposure group. The geometric mean toenail arsenic concentrations were 21.7 mg/kg for the drinking water exposure group and 32.1 mg/kg for the high-soil exposure group. Toenail arsenic concentrations were more strongly correlated with both drinking water and soil arsenic concentrations; however, there is a strong likelihood of significant external contamination. Measures of residential exposure were better predictors of hair and toenail arsenic concentrations than were local environmental concentrations.

show abstract

mentioning

confidence: 99%

Hair and toenail arsenic concentrations of residents living in areas with high environmental arsenic concentrations.

Hinwood

Sim

Jolley

et al. 2003

Environ Health Perspect

125

View full text Add to dashboard Cite

show abstract

“…They cite some new conference presentation material and an older occupational exposure study by Yamauchi et al (32). With regard to the chronic high inorganic As exposures in occupational settings and methylated As urinary profiles in workers, the 1986 study of Vahter (33) showed that the percent inorganic As in smelter workers' urine samples was virtually identical to the inorganic fraction of urines of a nonworker population of nonfish eaters, 18 and 19% respectively.…”

mentioning

confidence: 99%

Response: Accuracy, Arsenic, and Cancer

Mushak¹,

Crocetti²

1996

Environmental Health Perspectives

View full text Add to dashboard Cite

“…. a regression analysis on the individual data within the Yamauchi et al [4] population was borderline significant at p = 0.10. . ."…”

Section: Human Toxicity Of Pbdds and Pbdfsmentioning

confidence: 91%

Arsenic risk assessment.

Smith¹,

Biggs²,

Hopenhayn‐Rich³

et al. 1995

Environ Health Perspect

View full text Add to dashboard Cite

The brillant literature review and health risk assessment by Mennear and ChengChung, "Polybrominated Dibenzo-p-dioxins and Dibenzofurans: Literature Review and Health Assessment" [EHP 102(suppl 1):265-274], states that "reports of human toxicity associated with exposure to PBDDs and PBDFs were not found" (p. 272). In fact, in their review, no references are discussed or quoted regarding human studies.Two papers have been published on the human toxicology of these compounds. The first (1) is a recent report, previously presented at the Dioxin '90 Congress (2), about a chemist who was exposed to 2,3,7,8,-tetrabromodibenzodioxin (TBDD) and to 2,3,7, in March and September 1956, respectively, when synthesizing these chemicals. The chemist was defined as "in good health" in 1990, when determinations of chlorinated and brominated dioxins and dibenzofurans were performed on whole blood. High concentrations of several congeners were detected, and the results were used to discuss the half-life of the chemicals in humans. The subject presented a mild chloracne after an unspecified time from his exposure to bromodixoins in March, suggesting that TBDD could produce skin effects as chlorodioxins. Other more relevant symptoms occurred after the exposure to TCDD in September, and the patient was hospitalized for a short period.The second was a study of subjects exposed to PBDDs and PBDFs as a result of working at a BASF factory in etrusion blending of polybutyleneterphthalate with decarbromodiphenyl ether, used as a flame retardant. The intensity of exposure was determined in 1989 through air monitoring (3). The paper presents blood levels of 2,3,7,8,-TBDF and TBDD and of total congener profiles for some exposed workers and the results of a comparison of several immunological tests in a population of exposed versus a population of unexposed deriving from the same working cohort. Workers had detectable blood levels of TBDD and TBDF; half-life estimates of these chemicals are presented. The results of immunological tests were described as "not adversely impacted at these burdens of PBDFs and PBDDs," even though the results of several tests showed a correlation with exposure, and in the subject having the highest blood levels of PBDFs and PBDDs, immunological changes were quite relevant. The authors stated that clinical examination did not reveal "skin lesions consistent with an acnegenic response.It should be stressed that the results of the two quoted articles do not change the conclusions of Mennear and ChengChung on the health risks of PBDDs and PBDFs. However, slightly different suggestions for future research can be derived. Human populations have been or are exposed to these chemicals because of their use in several work processes involving flame retardants, environmental exposures (mainly due to municipal incinerators), or because of accidents due to thermal decomposition of flame retardants. These exposed human populations can be suitable, at least in theory, for toxicological and epidemiological observations.

show abstract

Biological Monitoring of Arsenic exposure of Gallium Arsenide- and Inorganic Arsenic-Exposed Workers by Determination of Inorganic Arsenic and Its Metabolites in Urine and Hair

Cited by 14 publications

References 0 publications

Hair and toenail arsenic concentrations of residents living in areas with high environmental arsenic concentrations.

Hair and toenail arsenic concentrations of residents living in areas with high environmental arsenic concentrations.

Response: Accuracy, Arsenic, and Cancer

Arsenic risk assessment.

Contact Info

Product

Resources

About