Biological potential of protein hydrolysates and peptides from common bean (Phaseolus vulgaris L.): A review

Luna‐Vital, Diego A.; Mojica, Luis; Mejı́a, Elvira González de; Mendoza, Sandra; Loarca-Piña, Guadalupe

doi:10.1016/j.foodres.2014.11.024

Cited by 153 publications

(91 citation statements)

References 101 publications

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“…Not only are they perilous for humans, they might have notorious influence on plants and may even kill them (Luna-Vital et al, 2015). Therapeutic options to fight against pathogen fungi seem to be very restricted since there are only few antifungals specialized for the pathogens .…”

Section: Antifungal Effectmentioning

confidence: 99%

“…In other words, the carcinogenic cells start out-of-control multiplication in the site they belong to without rendering the role they are originally supposed to. The transformed invasive cells can even cross through their own sites and enter, say, blood vein to cause more severe problems (Luna-Vital et al, 2015). There are several chemotherapeutics and targeted antineoplastic agents commercially available; however, although they prove to be very efficient against tumor and cancer, there have also been serious complaints regarding their adverse side-effects.…”

Section: Cytomodulatory Effectmentioning

confidence: 99%

“…Taken together, academic interest has shifted toward finding dietary agents in order to block or at least alleviate the effects of tumor or even to prevent outbreak of cancer. Bioactive peptides from different sources have been found to have antitumor effects (Attoub et al, 2013;Lin et al, 2013;Sun et al, 2014;Luna-Vital et al, 2015) (Table 1). Yet, no single mechanism has been detected for the peptides to cause tumor cell death, but their action mechanism includes nonspecific perturbation of the cell membrane and subsequent insertion into the lipid bilayer so as to disrupt cell membrane (Attoub et al, 2013).…”

Section: Cytomodulatory Effectmentioning

confidence: 99%

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Peptides: Production, bioactivity, functionality, and applications

Hajfathalian

Ghelichi

Moreno

et al. 2017

Critical Reviews in Food Science and Nutrition

138

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Production of peptides with various effects from proteins of different sources continues to receive academic attention. Researchers of different disciplines are putting increasing efforts to produce bioactive and functional peptides from different sources such as plants, animals, and food industry by-products. The aim of this review is to introduce production methods of hydrolysates and peptides and provide a comprehensive overview of their bioactivity in terms of their effects on immune, cardiovascular, nervous, and gastrointestinal systems. Moreover, functional and antioxidant properties of hydrolysates and isolated peptides are reviewed. Finally, industrial and commercial applications of bioactive peptides including their use in nutrition and production of pharmaceuticals and nutraceuticals are discussed.

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Section: Antifungal Effectmentioning

confidence: 99%

Section: Cytomodulatory Effectmentioning

confidence: 99%

Section: Cytomodulatory Effectmentioning

confidence: 99%

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Peptides: Production, bioactivity, functionality, and applications

Hajfathalian

Ghelichi

Moreno

et al. 2017

Critical Reviews in Food Science and Nutrition

138

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“…The common bean (Phaseolus vulgaris) is one of the most important sources of plant protein on the human diet (Luna-Vital et al, 2015). The life cycle of the plants is very short (70-100 days), which limits the crop size and decreases its competitive ability with weeds.…”

Section: Introductionmentioning

confidence: 99%

Tolerance of Common Bean Plants to Ethoxysulfuron Herbicide and the Mechanism Involved in the Process

et al. 2016

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-The objectives of this study were to determine the effect of herbicide ethoxysulfuron on the development of commom bean (Phaseolus vulgaris), to evaluate the impact of the herbicide on the crop grain yield and to determine the mechanism of tolerance of common bean to ethoxysulfuron. Field experiments were carried out with several doses of ethoxysulfuron to determine its effect on the grain yield of two varieties of common bean ("IPR Andorinha", "IPR Tangará"). The mechanism of plant tolerance was evaluated through several methods, including the analysis of the ALS enzyme sensitivity to herbicide and the use of P450 inhibitors (the insecticides malathion + chlorpyrifos) and the use of antidote (mefenpyr-diethyl). When the rate of ethoxysulfuron was 83.2 g ha -1 , the grain yield loss reached 25% (IPR Tangará) and 35% (IPR Andorinha). The ALS enzyme activity was severely reduced even at low concentrations ethoxysulfuron (1 μM), indicating that the mechanism of tolerance is not the insensitivity of the herbicide target enzyme. The inhibitors of herbicide detoxification increased the sensitivity of the bean plants to ethoxysulfuron, and the antidote (stimulator of herbicide degradation) mitigated the herbicidal effect. These results strongly support the hypothesis that the mechanism of tolerance of common bean plants to ethoxysulfuron is enhanced herbicide detoxification.Keywords: Phaseolus vulgaris, crop grain yield, ALS enzyme, detoxification. RESUMO -Os objetivos deste trabalho foram determinar o efeito do herbicida ethoxysulfuron sobre o desenvolvimento do feijoeiro (Phaseolus vulgaris), avaliar o impacto do herbicida sobre o rendimento de grãos e determinar o mecanismo de tolerância do feijoeiro ao ethoxysulfuron. Em campo, foram realizados dois experimentos com doses crescentes de ethoxysulfuron, a fim de determinar o seu efeito sobre o desenvolvimento e o rendimento de grãos de dois cultivares (cvs.) de feijão (IPR Andorinha e IPR Tangará). O mecanismo de tolerância das plantas foi determinado através da análise de sensibilidade da enzima ALS ao herbicida, do uso de inseticidas inibidores da P450 (malathion + chlorpyrifos) e do uso de antídoto (mefenpyr-diethyl). Quando a dose de ethoxysulfuron foi de 83,2 g ha -1 , as perdas de rendimento de grãos atingiram 25% (IPR Tangará) e 35% (IPR Andorinha

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“…Common bean (Phaseolus vulgaris L.) is a highly consumed legume worldwide that contains bioactive compounds including peptides. Activities described for common bean bioactive peptides (BP) include antioxidant, antihypertensive, anti-inflammatory, anticancer, antifungal, and antidiabetic (Luna-Vital et al, 2014;Rocha et al, 2015, Marques et al, 2015. The peptides can be obtained by enzymatic hydrolysis, fermentation, or food processes that hydrolyze or disrupt massive proteins groups like globulins.…”

Section: Introductionmentioning

confidence: 99%

Bioactive Peptides by in vitro Digestion of Germinated Bean Cotyledons Extrudates

López-Barrios¹,

Heredia‐Olea²,

Guajardo‐Flores³

et al. 2018

JFR

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Germinated black bean cotyledons were extruded at two different screw speeds (350 or 400 rpm). Extrudates were digested with pepsin and pancreatin to evaluate the antioxidant and anti-inflammatory activities of hydrolysates collected at 0, 60, 90, 120 and, 180 min. Soluble protein recovered before the enzymatic digestion of extrudates obtained at 350 rpm (E1), or 400 rpm (E2) showed the highest antioxidant (AOX) capacity, with 2,790 or 2,335 µmol eq Trolox/g, respectively and the best nitrogen oxide inhibitory. Even though extrudates presented different peptides profiles, the enzymatic digestion of the storage proteins released similar peptides. RLL and YAL were among the identified peptides obtained after 180 min of enzymatic digestion. Extrusion can be a useful process to produce novel functional ingredients from legume proteins for the food industry.

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Biological potential of protein hydrolysates and peptides from common bean (Phaseolus vulgaris L.): A review

Cited by 153 publications

References 101 publications

Peptides: Production, bioactivity, functionality, and applications

Peptides: Production, bioactivity, functionality, and applications

Tolerance of Common Bean Plants to Ethoxysulfuron Herbicide and the Mechanism Involved in the Process

Bioactive Peptides by in vitro Digestion of Germinated Bean Cotyledons Extrudates

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