Biological Properties and Antioxidant Activity of Hawthorn Crataegus mexicana

Antonio, eras-Tarabay José; Cervantes-Rodríguez, Margarita; Daniel, Méndez-Iturbide

doi:10.4172/2153-0645.1000153

Cited by 5 publications

(5 citation statements)

References 41 publications

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“…Traditionally, hawberry is harvested by many citizens and village inhabitants for their own needs and used in folk medicine for treatment of hypertension, obesity, and menopause and improving memory in Mexico [3], Poland [4], and Portugal [5]. Numerous studies have confirmed that standardized Crataegus spp.…”

Section: Introductionmentioning

confidence: 99%

Advantageous Extraction, Cleanup, and UHPLC-MS/MS Detection of Patulin Mycotoxin in Dietary Supplements and Herbal Blends Containing Hawberry from Crataegus spp.

Przybylska

Bazylak

Kosicki

et al. 2019

Journal of Analytical Methods in Chemistry

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Patulin (PAT) is a highly genotoxic mycotoxin still found as the common contaminant of various kinds of spoiled fruits and related commodities which are often endorsed as the health-enhancing products. Thus, a fast and convenient liquid-solid extraction followed by a solid-phase cleanup with the MycoSep®228 AflaPat multifunctional column was used for the highly efficient isolation of PAT with an average recovery of 112.7% from commercial dietary supplements and herbal blends formulated with dried hawberry. Analysis of the PAT content was carried out using gradient elution with a Synergi Polar C18 column (150 × 2 mm, 4 μm) and UHPLC system equipped with a mass spectrometer. PAT was detected in all (n=14) commercial single-component dietary supplements formulated with dried hawberry belonging to Crataegus monogyna and/or Crataegus laevigata. Similarly, PAT was detected in 67% of the studied multicomponent commercial herbal blends (n=6) that contained—in addition to hawberry—different amounts of apple, chokeberry, elderberry, hibiscus, or mallow. Moreover, the PAT content was determined in the hawberry collected from the mature wild hawthorn trees belonging to three botanical species, Crataegus monogyna Jacq., Crataegus laevigata (Poiret) DC, and Crataegus rhipidophylla Gand, growing in the recreational forest areas and in the law-protected state national forest park in Poland. In conclusion, to prevent PAT accumulation and reduce the health risk of consumers in globalizing markets, the implementation of improved cultivation/processing practices of hawthorn trees and hawberry as well as increased analytical control related to the presence of PAT in dietary supplements and herbal blends formulated with fresh, dried, or frozen hawberry should be urgently recommended.

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Section: Introductionmentioning

confidence: 99%

Advantageous Extraction, Cleanup, and UHPLC-MS/MS Detection of Patulin Mycotoxin in Dietary Supplements and Herbal Blends Containing Hawberry from Crataegus spp.

Przybylska

Bazylak

Kosicki

et al. 2019

Journal of Analytical Methods in Chemistry

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“…These compounds have been shown to induce vasorelaxant and antihypertensive effects ( Aggio et al, 2013 , Novakovic et al, 2017 , Patel et al, 2018 , Sánchez et al, 2018 , Vechi et al, 2019 ). Therefore, it was very likely that these secondary metabolites could significantly contribute to the vasodilation elicited by the crude extracts obtained from C. mexicana leaves, especially considering that these compounds have been identified in fruits and leaves of other Mexican Crataegus species ( Banderas-Tarabay et al, 2015 , García-Mateos et al, 2013 ).…”

Section: Resultsmentioning

confidence: 99%

“…At least thirteen species belonging to the genus Crataegus have been identified in Mexico and the most common species are C. mexicana and C. gracilior ( Banderas-Tarabay et al, 2015 ). All Crataegus species are commonly known in Mexico as Tejocote , a word originated from the nahuatl term tetl-xocotl , which means wild or hard sour fruit ( Martínez, 1991 ).…”

Section: Introductionmentioning

confidence: 99%

Development of a quantified herbal extract of hawthorn Crataegus mexicana leaves with vasodilator effect

Ornelas-Lim

Luna-Vázquez

Rojas‐Molina

et al. 2021

Saudi Pharmaceutical Journal

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Hawthorn ( Crataegus spp .) has been used for the treatment of several heart diseases and hypertension. The studies carried out on several hawthorn species have led to the development of standardized extracts useful in the cure of mild chronic cardiac diseases. In Mexico, the most common Crataegus species are C. mexicana and C. gracilior . Decoctions prepared from the fruits and leaves of these species have been employed to the treat respiratory diseases, tachycardia and to improve coronary blood flow. Considering that to date there are no reports of the use of Mexican Crataegus species to treat cardiovascular diseases, we propose an analytical method to obtain a quantified extract of Crataegus mexicana leaves for the development of a standardized extract with therapeutic value in cardiovascular diseases as an alternative source to the extracts obtained from Crataegus species of European and Asian origin. Therefore, the aim of this study was to obtain an extract prepared from C. mexicana leaves with the highest vasodilator activity to select the optimal chemical marker to stablish and validate a reversed-phase high-performance liquid chromatography (RPHPLC-DAD) analytical method for obtaining a quantified extract with vasodilator effect. The results obtained from the analytical method validation, which was carried out according to the guidelines stablished in the Eurachem Guide and the ICH guidelines proved that the RPHPLC-DAD method we developed was specific, precise, accurate, and showed good linearity over the concentration range of 3 – 21 µg/ml for (-)-epicatechin and rutin, which were selected as chemical markers.

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“…The term "Tejocote" -from the Nahuatl word Texocotl ("stone fruit") -directly refers to these small, round, yellow-orange fruits (Figure 1). They are traditionally used as pinata fillers, consumed directly, or used to make ponche (a brewed drink), marmalade, and other confections [2]. "Tejocote" also broadly refers to a pectin-rich preparation of the dried root of C. mexicana (marketed under the names Alipotec®/Tejocotex) that lowers appetite and promotes early satiety, leading to weight loss [3] (Figure 2).…”

Section: Discussionmentioning

confidence: 99%

“…No documented literature attributes the consumption of C. mexicana to acute transaminitis or hepatotoxicity. In fact, studies demonstrate the flavonoids and phenolic acids contained within the plant possess antioxidant properties, providing hepatoprotective benefits against free radicals and reactive oxygen species [2,7,8]. Famotidine, taken alone, has been implicated as a rare cause of temporary druginduced liver injury due to its activation into a toxic metabolite via the CYP450 system [9]; however, this requires chronic use at higher doses that did not occur with our patient.…”

Section: Figure 3: Ekg Demonstrating Digoxin-like Effects In a Patien...mentioning

confidence: 93%

The Dangers of Unregulated Weight Loss Supplements: Tejocote-Induced Acute Liver Injury

Blackmer,

Elsayad

2024

Cureus

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Tejocote, a product of the hawthorn tree and a common staple of Hispanic culinary practices and traditional medicine, has recently gained traction in the United States and Mexico as a means to achieve rapid effortless weight loss. This herbal supplement has largely evaded regulation by governing bodies in both countries despite documentation of several potentially serious adverse effects associated with its use. The present report describes the case of a middle-aged Hispanic female who ingested Tejocote with famotidine and presented with acute gastrointestinal symptoms and transaminitis, an unexpected symptom that warrants further investigation.

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Biological Properties and Antioxidant Activity of Hawthorn Crataegus mexicana

Cited by 5 publications

References 41 publications

Advantageous Extraction, Cleanup, and UHPLC-MS/MS Detection of Patulin Mycotoxin in Dietary Supplements and Herbal Blends Containing Hawberry from Crataegus spp.

Advantageous Extraction, Cleanup, and UHPLC-MS/MS Detection of Patulin Mycotoxin in Dietary Supplements and Herbal Blends Containing Hawberry from Crataegus spp.

Development of a quantified herbal extract of hawthorn Crataegus mexicana leaves with vasodilator effect

The Dangers of Unregulated Weight Loss Supplements: Tejocote-Induced Acute Liver Injury

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