Herbal medicines have been used for a wide range of ailments since ancient times. Two methods are used in Ayurvedic medicine formulation: one involves employing a single herbal preparation, or multiple combinations of them. Polyherbal formulation is the term for the later. Combining different herbs and plants to treat different medical diseases or to enhance general health is known as polyherbal medicine. Many civilizations all over the world have been using this kind of traditional medicine for centuries, and it is still commonly used today. Due to the active phytoconstituents found in single herbs, which are typically present in minute amounts and occasionally insufficient to produce the desired therapeutic effects, multi herb formulations have a well-established track record. According to scientific research, combining these plants with different potencies may theoretically result in a greater effect than using each plant alone or the sum of their individual effects. Positive interactions between herbs can therefore produce synergistic effect, which may take the form of pharmacokinetic or pharmacodynamic synergism. The great efficacy of polyherbal formulations in treating a wide range of illnesses accounts for their popularity. The growing demand of polyherbal formulations necessitates further scientific investigation in this area.