Biological properties of ristocetin-.PSI.-aglycone.

Abstract

Ristocetin-aglycone obtained by acid hydrolysis of ristocetin A, has a substantially greater antimicrobial activity against Gram-positive bacteria than the parent compound. None of the substances are active against Gram-negative bacteria, yeast or fungi. The ?P-aglycone is several times more toxic than ristocetin A when administered intravenously. Both substances are well-tolerated when given subcutaneously, intraperitoneally and perorally. Both ristocetin A and the IIT-aglycone have a very low absorption after oral administration. Plasma levels following intravenous administration of ristocetin A and the 7h'-aglycone are comparable, with both showing a rapid decline during the first 60 minutes followed by a somewhat slower elimination. The aggregating properties of the IF-aglycone could not be determined due to its low solubility at neutral pH.

Rapid micro fluorescence in situ hybridization in tissue sections

“…The sequences were adapted from Ref. 31. The 10× FITC-labelled HER-2 SureFISH probe was purchased from DAKO (Cat.…”

Teicoplanin, antibiotics from Actinoplanes teichomyceticus nov. sp. VII Preparation and NMR characteristics of the aglycone of teicoplanin.

“…XXXIX NO. 10 THE JOURNAL OF ANTIBIOTICS UV spectrum was recorded on a Unicam SP 800 spectrometer. HPLC were run with a Varian Model 5000LC pump equipped with a 20 pl loop injector Rheodyne Model 7125 and a Perkin-Elmer LC15 detector at 254 nm.…”

Reviewing the Sacarweb Design Based in Discount Usability Engineering

“…Sometimes the professionals simply do not give the necessary importance to usability, thinking only in working software. Even considering those that think important to adopt usability techniques during the design, it is supposed that such techniques are difficult to learn and use, once they require high knowledge and experience [7].…”

“…One approach example is the full Usability Engineering life cycle, consisting of eleven general stages, where various options of methods are available, including traditional ones. Such approaches can discourage the adoption of usability techniques in teams without or little knowledge about them [7].…”

“…There are alternative approaches to traditional methods to evaluate software usability with similar quality of results indicated for people that know the importance of software usability, but do not have enough resources, or the necessary knowledge to adopt traditional methods [7]. One of these approaches is known by Discount Usability [8], that uses only the most important techniques of the full Usability Engineering.…”