Biological properties of sulfanilamide-loaded alginate hydrogel fibers based on ionic and chemical crosslinking for wound dressings

Synthesis, classification and properties of hydrogels: their applications in drug delivery and agriculture

“…92 Similarly, a gelatin/alginate hydrogel is prepared by using glutaraldehyde as the crosslinking agent. 93 Chemical crosslinking is an extremely adaptable technique to improve the mechanical strength of hydrogels. However, crosslinking agents are generally toxic compounds and are not environmentally friendly.…”

A review on the synthesis and development of alginate hydrogels for wound therapy

“…Chemical crosslinkers are very convenient to use, and the current commonly used chemical crosslinkers are glutaraldehyde, poly (ethylene glycol) diacrylate 90 and others. 91 For example, Sun, Xiaoqing et al 92 used calcium ions to make a sodium alginate crosslinking point, and used glutaraldehyde to react with hydroxyl in sodium alginate structural unit to form a covalent bond crosslinking point. Chemical crosslinking agents are widely used in industrial production, but researchers in medical and health fields usually avoid using chemical crosslinking agents.…”

“…It has been reported that the appropriate use of glutaraldehyde does not have a significant impact on drug loading, nor does it significantly increase the cytotoxicity of hydrogels. 92,93 However, in most cases, the biocompatibility of hydrogels will decrease after the use of small molecular chemical crosslinking agents. It has been reported that biological components such as DNA can also be used as crosslinking agents, and their biocompatibility is higher than that of industrial crosslinking agents such as glutaraldehyde.…”

Progress in Antibacterial Hydrogel Dressing

“…Sun et al prepared sodium alginate double crosslinking hydrogel fibers loaded with sulfadiazine and crosslinked with calcium ion and glutaraldehyde. The sodium alginate hydrogel fibers had good mechanical strength, biocompatibility, and sustainable drug release, and the antibacterial test showed that the antibacterial hydrogel could kill 99.9% of Staphylococcus aureus and Escherichia coli [ 85 ].…”