Biological properties of transition-metal organometallic compounds. 3. .beta.-Ferrocenylalanine

Synthesis, structure characterization and preliminary biological evaluation of novel 5-alkyl-2-ferrocenyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives

“…Recently, ferrocene and its derivatives have been attracted much more attention in the biological activities [2,3]. Incorporation of a ferrocene fragment into a molecule of an organic compound often obtained unexpected biological activity, which is rationalized as being due to their different membrane permeation properties and anomalous metabolism [4]. Furthermore, the stability and non-toxicity of the ferrocenyl moiety is of particular interest rendering such drugs compatible with other treatment [5][6][7].…”

“…Although much work has been directed toward the design and synthesis of fused-pyrazole derivatives [16][17][18][19][20][21], a search of the literatures revealed very few reports concerning pyrazolo-pyrazinones [22]. In the previous papers, we synthesized a series of novel pyrazole derivatives including ethyl 1-(2 0 -hydroxy-3 0 -aroxypropyl)-3-aryl-1H-pyrazole-5-carboxylate derivatives [23], 6-(aroxymethyl)-2-aryl-6,7-dihydropyrazolo [5,1- c] [1,4]oxazin-4-one derivatives [24], ethyl 1-arylmethyl-3-aryl-1H-pyrazole-5-carboxylate derivatives [25], 1-arylmethyl-3-aryl-1H-pyrazole-5-carbohydrazide derivatives [26] and 1-arylmethyl-3-aryl-1H-pyrazole-5-carbohydrazide hydrazone derivatives [27]. The evaluation of biological activity showed that these compounds can inhibit A549 lung cancer cell growth.…”

A facile and expeditious microwave-assisted synthesis of 4-aryl-2-ferrocenyl-quinoline derivatives via multi-component reaction

“…Ferrocene derivatives containing heterocyclic systems have attracted special attention in recent years [2][3][4][5][6][7] because of their organic and inorganic properties, as well as for their applications in various areas including components of molecular wires [8], anion sensors [9] and potential organic ferromagnets [10]. Compared with the classical heterocyclic compounds, incorporation of a ferrocene fragment into heterocycles often obtained unexpected biological activity [11]. Furthermore, ferrocene has been studied extensively as it is thought to be responsible for a variety of biological stability and non-toxicity rendering such drugs compatible with other treatment [12][13][14].…”

Toxicology and antitumour activity of ferrocenylamines and platinum derivatives

“…20 Compounds in which the cis-Pt(II) and ferrocenyl moieties are combined may also be expected to exhibit biological activity. 21 Thus, (dppf)PtCl 2 , [(dppf)Pt(m-Cl)] 2 2 , [(dppf)Pt (m-OH)] 2 2 and [(dppf)Pt(DMF) 2 ] 2 [DPPF = 1,1bis(diphenylphosphinoferrocene); DMF = dimethylformamide; lower-case abbreviations are used for legends in complexes (i.e. dppf, dmf)] have been shown to exhibit cytostatic activity in vitro against the KB cell line.…”