2019
DOI: 10.1016/j.ica.2019.118974
|View full text |Cite
|
Sign up to set email alerts
|

Biological relevance of interaction of platinum drugs with O-donor ligands

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1

Citation Types

0
5
0

Year Published

2020
2020
2024
2024

Publication Types

Select...
7
1

Relationship

1
7

Authors

Journals

citations
Cited by 10 publications
(5 citation statements)
references
References 44 publications
0
5
0
Order By: Relevance
“…We have previously suggested that the O-donor polyanionic biomolecules such as GAGs present multiple neighboring donors on a more complex polymeric, biomolecular template acting as a Lewis base "sink". 24 Both carboxylate and sulfate interactions play an important role in the overall triplatin− GAG interaction. The relative importance of both will be highly dependent on the sulfation status in longer-chain HS.…”
Section: ■ Conclusionmentioning
confidence: 99%
“…We have previously suggested that the O-donor polyanionic biomolecules such as GAGs present multiple neighboring donors on a more complex polymeric, biomolecular template acting as a Lewis base "sink". 24 Both carboxylate and sulfate interactions play an important role in the overall triplatin− GAG interaction. The relative importance of both will be highly dependent on the sulfation status in longer-chain HS.…”
Section: ■ Conclusionmentioning
confidence: 99%
“…[5,6] Beyond its fundamental nature, the significance of the trans effect extends to comprehending and constructing reaction mechanisms that elucidate the interaction between platinum-based anticancer compounds and biological targets within an aqueous environment. [7][8][9][10] A well-structured mechanism stands as a crucial factor in advancing the development of more efficient potential drug candidates, particularly in the realm of new anticancer agents with enhanced pharmacokinetic profiles. [10,11] In all scenarios, whether in conventional inorganic synthesis or processes occurring within biological environments, the kinetic nature of the phenomenon underscores the vital importance of a precise comprehension of the trans effect.…”
Section: Introductionmentioning
confidence: 99%
“…[ 5,6 ] Beyond its fundamental nature, the significance of the trans effect extends to comprehending and constructing reaction mechanisms that elucidate the interaction between platinum‐based anticancer compounds and biological targets within an aqueous environment. [ 7–10 ] A well‐structured mechanism stands as a crucial factor in advancing the development of more efficient potential drug candidates, particularly in the realm of new anticancer agents with enhanced pharmacokinetic profiles. [ 10,11 ]…”
Section: Introductionmentioning
confidence: 99%
“…It has been suggested that, upon intracellular hydrolysis of their leaving ligands (e.g., chlorides), they interact with their main pharmacological target (DNA) via non-conventional bonds—since they allow the formation of intra- and interstrand long-range adducts (not available for the conventional mononuclear Pt-drugs (e.g., cisplatin))—leading to an enhanced and less-repairable therapeutic effect [ 9 , 15 , 17 ]. More recently, a new class of polycationic platinum chelates without hydrolysable moieties was developed by Farrell et al [ 18 , 19 , 20 , 21 , 22 ]. Instead of covalently binding to DNA, these compounds impact on the nucleic acid through electrostatic interactions with the phosphate groups, the so-called phosphate clamps.…”
Section: Introductionmentioning
confidence: 99%