Biological response modifiers and their promise in clinical medicine

Attallah, Abdelfattah M.; Yeatman, T. J.; Johnson, Robert P.; Petricciani, John C.

doi:10.1016/0163-7258(82)90076-6

Cited by 3 publications

(1 citation statement)

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“…Cytokines, or the then named 'biological response modifiers' [3,29], hold promising avenue for the antiinflammatory therapeutic approach of thymulin [21,23]. The first association emerged with IL-2 and thymulin, which synergistically enabled autologous rosette-forming T lymphocytes to generate helper and cytotoxic functions in normal [77] and nude [49] mice.…”

Section: Thymulin and Inflammatory Mediatorsmentioning

confidence: 99%

Thymulin: An Emerging Anti-Inflammatory Molecule

Haddad¹,

Saadé

Safieh‐Garabedian

2005

CMCAIAA

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Thymulin is a neuroendocrine hormone with immunoregulatory actions. Originally known as 'serum thymic factor' (FTS), thymulin binds to a carrier protein and zinc (Zn2+) to exert its biologic properties. Thymulin, albeit an essential hormone for the T lymphocyte differentiation and the normalization of the ratio of T-helper cells to suppressor cells, accumulating evidence suggests its involvement in inflammations of various etiologies. Recently, thymulin has been shown to have anti-nociceptive effects in hyperalgesia and in pain of neurogenic origin, ostensibly through action on sensory afferents and the release of anti-inflammatory mediators. Given its anti-inflammatory potential, thymulin downregulates the release of inflammatory mediators, such as cytokines and chemokines, upregulates anti-inflammatory factors, such as interleukin (IL)-10, and exerts molecular control via the regulation of transcription factors and mediators. Recent evidence tends to indicate that thymulin can be a therapeutic agent in many inflammatory diseases and in pathological conditions affecting the peripheral and/or the central nervous system. This review discusses current concepts in the antiinflammatory actions of thymulin and correlates this activity with an emerging theme for therapeutic treatment.

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